Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. (Articolo in rivista)

Type
Label
  • Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. (Articolo in rivista) (literal)
Anno
  • 2013-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1038/ng.2610 (literal)
Alternative label
  • den Hoed M, Eijgelsheim M, Esko T, Brundel BJ, Peal DS, Evans DM, Nolte IM, Segrè AV, Holm H, Handsaker RE, Westra HJ, Johnson T, Isaacs A, Yang J, Lundby A, Zhao JH, Kim YJ, Go MJ, Almgren P, Bochud M, Boucher G, Cornelis MC, Gudbjartsson D, Hadley D, van der Harst P, Hayward C, den Heijer M, Igl W, Jackson AU, Kutalik Z, Luan J, Kemp JP, Kristiansson K, Ladenvall C, Lorentzon M, Montasser ME, Njajou OT, O'Reilly PF, Padmanabhan S, St Pourcain B, Rankinen T, Salo P, Tanaka T, Timpson NJ, Vitart V, Waite L, Wheeler W, Zhang W, Draisma HH, Feitosa MF, Kerr KF, Lind PA, Mihailov E, Onland-Moret NC, Song C, Weedon MN, Xie W, Yengo L, Absher D, Albert CM, Alonso A, Arking DE, de Bakker PI, Balkau B, Barlassina C, Benaglio P, Bis JC, Bouatia-Naji N, Brage S, Chanock SJ, Chines PS, Chung M, Darbar D, Dina C, Dörr M, Elliott P, Felix SB, Fischer K, Fuchsberger C, de Geus EJ, Goyette P, Gudnason V, Harris TB, Hartikainen AL, Havulinna AS, Heckbert SR, Hicks AA, Hofman A, Holewijn S, Hoogstra-Berends F, Hottenga JJ, Jensen MK, Johansson A, Junttila J, Kääb S, Kanon B, Ketkar S, Khaw KT, Knowles JW, Kooner AS, Kors JA, Kumari M, Milani L, Laiho P, Lakatta EG, Langenberg C, Leusink M, Liu Y, Luben RN, Lunetta KL, Lynch SN, Markus MR, Marques-Vidal P, Mateo Leach I, McArdle WL, McCarroll SA, Medland SE, Miller KA, Montgomery GW, Morrison AC, Müller-Nurasyid M, Navarro P, Nelis M, O'Connell JR, O'Donnell CJ, Ong KK, Newman AB, Peters A, Polasek O, Pouta A, Pramstaller PP, Psaty BM, Rao DC, Ring SM, Rossin EJ, Rudan D, Sanna S, Scott RA, Sehmi JS, Sharp S, Shin JT, Singleton AB, Smith AV, Soranzo N, Spector TD, Stewart C, Stringham HM, Tarasov KV, Uitterlinden AG, Vandenput L, Hwang SJ, Whitfield JB, Wijmenga C, Wild SH, Willemsen G, Wilson JF, Witteman JC, Wong A, Wong Q, Jamshidi Y, Zitting P, Boer JM, Boomsma DI, Borecki IB, van Duijn CM, Ekelund U, Forouhi NG, Froguel P, Hingorani A, Ingelsson E, Kivimaki M, Kronmal RA, Kuh D, Lind L, Martin NG, Oostra BA, Pedersen NL, Quertermous T, Rotter JI, van der Schouw YT, Verschuren WM, Walker M, Albanes D, Arnar DO, Assimes TL, Bandinelli S, Boehnke M, de Boer RA, Bouchard C, Caulfield WL, Chambers JC, Curhan G, Cusi D, Eriksson J, Ferrucci L, van Gilst WH, Glorioso N, de Graaf J, Groop L, Gyllensten U, Hsueh WC, Hu FB, Huikuri HV, Hunter DJ, Iribarren C, Isomaa B, Jarvelin MR, Jula A, Kähönen M, Kiemeney LA, van der Klauw MM, Kooner JS, Kraft P, Iacoviello L, Lehtimäki T, Lokki ML, Mitchell BD, Navis G, Nieminen MS, Ohlsson C, Poulter NR, Qi L, Raitakari OT, Rimm EB, Rioux JD, Rizzi F, Rudan I, Salomaa V, Sever PS, Shields DC, Shuldiner AR, Sinisalo J, Stanton AV, Stolk RP, Strachan DP, Tardif JC, Thorsteinsdottir U, Tuomilehto J, van Veldhuisen DJ, Virtamo J, Viikari J, Vollenweider P, Waeber G, Widen E, Cho YS, Olsen JV, Visscher PM, Willer C, Franke L; Global BPgen Consortium; CARDIoGRAM Consortium, Erdmann J, Thompson JR; PR GWAS Consortium, Pfeufer A; QRS GWAS Consortium, Sotoodehnia N; QT-IGC Consortium, Newton-Cheh C; CHARGE-AF Consortium, Ellinor PT, Stricker BH, Metspalu A, Perola M, Beckmann JS, Smith GD, Stefansson K, Wareham NJ, Munroe PB, Sibon OC, Milan DJ, Snieder H, Samani NJ, Loos RJ. (2013)
    Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders.
    in Nature genetics (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • den Hoed M, Eijgelsheim M, Esko T, Brundel BJ, Peal DS, Evans DM, Nolte IM, Segrè AV, Holm H, Handsaker RE, Westra HJ, Johnson T, Isaacs A, Yang J, Lundby A, Zhao JH, Kim YJ, Go MJ, Almgren P, Bochud M, Boucher G, Cornelis MC, Gudbjartsson D, Hadley D, van der Harst P, Hayward C, den Heijer M, Igl W, Jackson AU, Kutalik Z, Luan J, Kemp JP, Kristiansson K, Ladenvall C, Lorentzon M, Montasser ME, Njajou OT, O'Reilly PF, Padmanabhan S, St Pourcain B, Rankinen T, Salo P, Tanaka T, Timpson NJ, Vitart V, Waite L, Wheeler W, Zhang W, Draisma HH, Feitosa MF, Kerr KF, Lind PA, Mihailov E, Onland-Moret NC, Song C, Weedon MN, Xie W, Yengo L, Absher D, Albert CM, Alonso A, Arking DE, de Bakker PI, Balkau B, Barlassina C, Benaglio P, Bis JC, Bouatia-Naji N, Brage S, Chanock SJ, Chines PS, Chung M, Darbar D, Dina C, Dörr M, Elliott P, Felix SB, Fischer K, Fuchsberger C, de Geus EJ, Goyette P, Gudnason V, Harris TB, Hartikainen AL, Havulinna AS, Heckbert SR, Hicks AA, Hofman A, Holewijn S, Hoogstra-Berends F, Hottenga JJ, Jensen MK, Johansson A, Junttila J, Kääb S, Kanon B, Ketkar S, Khaw KT, Knowles JW, Kooner AS, Kors JA, Kumari M, Milani L, Laiho P, Lakatta EG, Langenberg C, Leusink M, Liu Y, Luben RN, Lunetta KL, Lynch SN, Markus MR, Marques-Vidal P, Mateo Leach I, McArdle WL, McCarroll SA, Medland SE, Miller KA, Montgomery GW, Morrison AC, Müller-Nurasyid M, Navarro P, Nelis M, O'Connell JR, O'Donnell CJ, Ong KK, Newman AB, Peters A, Polasek O, Pouta A, Pramstaller PP, Psaty BM, Rao DC, Ring SM, Rossin EJ, Rudan D, Sanna S, Scott RA, Sehmi JS, Sharp S, Shin JT, Singleton AB, Smith AV, Soranzo N, Spector TD, Stewart C, Stringham HM, Tarasov KV, Uitterlinden AG, Vandenput L, Hwang SJ, Whitfield JB, Wijmenga C, Wild SH, Willemsen G, Wilson JF, Witteman JC, Wong A, Wong Q, Jamshidi Y, Zitting P, Boer JM, Boomsma DI, Borecki IB, van Duijn CM, Ekelund U, Forouhi NG, Froguel P, Hingorani A, Ingelsson E, Kivimaki M, Kronmal RA, Kuh D, Lind L, Martin NG, Oostra BA, Pedersen NL, Quertermous T, Rotter JI, van der Schouw YT, Verschuren WM, Walker M, Albanes D, Arnar DO, Assimes TL, Bandinelli S, Boehnke M, de Boer RA, Bouchard C, Caulfield WL, Chambers JC, Curhan G, Cusi D, Eriksson J, Ferrucci L, van Gilst WH, Glorioso N, de Graaf J, Groop L, Gyllensten U, Hsueh WC, Hu FB, Huikuri HV, Hunter DJ, Iribarren C, Isomaa B, Jarvelin MR, Jula A, Kähönen M, Kiemeney LA, van der Klauw MM, Kooner JS, Kraft P, Iacoviello L, Lehtimäki T, Lokki ML, Mitchell BD, Navis G, Nieminen MS, Ohlsson C, Poulter NR, Qi L, Raitakari OT, Rimm EB, Rioux JD, Rizzi F, Rudan I, Salomaa V, Sever PS, Shields DC, Shuldiner AR, Sinisalo J, Stanton AV, Stolk RP, Strachan DP, Tardif JC, Thorsteinsdottir U, Tuomilehto J, van Veldhuisen DJ, Virtamo J, Viikari J, Vollenweider P, Waeber G, Widen E, Cho YS, Olsen JV, Visscher PM, Willer C, Franke L; Global BPgen Consortium; CARDIoGRAM Consortium, Erdmann J, Thompson JR; PR GWAS Consortium, Pfeufer A; QRS GWAS Consortium, Sotoodehnia N; QT-IGC Consortium, Newton-Cheh C; CHARGE-AF Consortium, Ellinor PT, Stricker BH, Metspalu A, Perola M, Beckmann JS, Smith GD, Stefansson K, Wareham NJ, Munroe PB, Sibon OC, Milan DJ, Snieder H, Samani NJ, Loos RJ. (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK. Marcel den Hoed, Jing Hua Zhao, Jian'an Luan, Søren Brage, Claudia Langenberg, Ken K Ong, Robert A Scott, Stephen Sharp, Ulf Ekelund, Nita G Forouhi, Nicholas J Wareham & Ruth J F Loos Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden. Marcel den Hoed & Erik Ingelsson Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands. Mark Eijgelsheim, Aaron Isaacs, Albert Hofman, André G Uitterlinden, Jacqueline C M Witteman, Cornelia M van Duijn & Bruno H Ch Stricker Estonian Biocenter, Tartu, Estonia. Tõnu Esko, Evelin Mihailov, Mari Nelis & Andres Metspalu Estonian Genome Center, University of Tartu, Tartu, Estonia. Krista Fischer, Lili Milani, Mari Nelis, Andres Metspalu & Markus Perola Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia. Evelin Mihailov & Andres Metspalu Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. Bianca J J M Brundel & Femke Hoogstra-Berends Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA. David S Peal, Stacey N Lynch, Jordan T Shin & David J Milan MRC Centre for Causal Analyses in Translational Epidemiology (CAiTE), School of Social and Community Medicine, University of Bristol, Bristol, UK. David M Evans, John P Kemp, Beate St. Pourcain, Nicholas J Timpson & George Davey Smith Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. Ilja M Nolte, Ronald P Stolk & Harold Snieder Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, USA. Ayellet V Segrè Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA. Ayellet V Segrè, Robert E Handsaker, Paul I W de Bakker, Steven A McCarroll & Christopher Newton-Cheh deCODE Genetics, Reykjavik, Iceland. Hilma Holm, Daniel Gudbjartsson, Unnur Thorsteinsdottir & Kari Stefansson Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA. Robert E Handsaker & Steven A McCarroll Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. Harm-Jan Westra, Cisca Wijmenga & Lude Franke Clinical Pharmacology, National Institute for Health Research (NIHR) Cardiovascular Biomedical Research Unit, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. Toby Johnson, W L Mark Caulfield & Patricia B Munroe Genome Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. Toby Johnson, W L Mark Caulfield & Patricia B Munroe Centre for Medical Systems Biology, Leiden, The Netherlands. Aaron Isaacs & Cornelia M van Duijn Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK. Jian Yang & Nicole Soranzo Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA. Alicia Lundby, Sarah E Medland, Elizabeth J Rossin & Chip Stewart The Danish National Research Foundation Centre for Cardiac Arrhythmia, Copenhagen, Denmark. Novo Nordisk Foundation Center for Protein Research, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark. Jesper V Olsen Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Daejeon, The Republic of Korea. Young Jin Kim & Min Jin Go Department of Clinical Sciences, Diabetes and Endocrinology, Lund University and Lund University Diabetes Centre, Malmö, Sweden. Peter Almgren, Claes Ladenvall & Leif Groop Community Prevention Unit, Institute of Social and Preventive Medicine, Lausanne University Hospital, Lausanne, Switzerland. Murielle Bochud Université de Montréal, Montreal, Quebec, Canada. Gabrielle Boucher, Philippe Goyette, John D Rioux & Jean-Claude Tardif Montreal Heart Institute, Montreal, Quebec, Canada. Gabrielle Boucher, Philippe Goyette, John D Rioux & Jean-Claude Tardif Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA. Marilyn C Cornelis, Majken K Jensen, Frank B Hu, Lu Qi & Eric B Rimm Division of Population Health Sciences and Education, St. George's, University of London, London, UK. David Hadley & David P Strachan Pediatric Epidemiology Center, University of South Florida, Tampa, Florida, USA. David Hadley Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. Pim van der Harst, Irene Mateo Leach, Rudolf A de Boer, Wiek H van Gilst & Dirk J van Veldhuisen MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK. Caroline Hayward, Veronique Vitart & Pau Navarro Department of Internal Medicine, VU Medical Center, Amsterdam, The Netherlands. Martin den Heijer Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden. Wilmar Igl, Åsa Johansson & Ulf Gyllensten Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA. Anne U Jackson, Christian Fuchsberger, Heather M Stringham & Michael Boehnke Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA. Anne U Jackson, Heather M Stringham & Michael Boehnke Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland. Zoltán Kutalik, Paola Benaglio & Jacques S Beckmann Swiss Institute of Bioinformatics, Lausanne, Switzerland. Zoltán Kutalik The Institute of Molecular Medicine, University of Helsinki, Helsinki, Finland. Kati Kristiansson, Perttu Salo & Markus Perola Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland. Kati Kristiansson Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. Mattias Lorentzon, Liesbeth Vandenput & Claes Ohlsson Department of Medicine, Division of Endocrinology, Diabetes and Nutrition, University of Maryland, School of Medicine, Baltimore, Maryland, USA. May E Montasser, Jeffrey R O'Connell, Braxton D Mitchell & Alan R Shuldiner Department of Medicine, Institute for Human Genetics, University of California, San Francisco, San Francisco, California, USA. Omer T Njajou & Wen-Chi Hsueh Department of Epidemiology and Biostatistics, Imperial College London, London, UK. Paul F O'Reilly, Weihua Zhang, Paul Elliott, Kathryn A Miller, John C Chambers & Marjo-Riitta Jarvelin MRC-Health Protection Agency (MRC-HPA) Centre for Environment and Health, Imperial College London, London, UK. Paul F O'Reilly, Paul Elliott & Marjo-Riitta Jarvelin Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK. Sandosh Padmanabhan Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA. Tuomo Rankinen & Claude Bouchard Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland. Perttu Salo, Aki S Havulinna, Johan Eriksson, Veikko Salomaa, Jarmo Virtamo & Markus Perola Clinical Research Branch, National Institute on Aging, Baltimore, Maryland, USA. Toshiko Tanaka & Luigi Ferrucci HudsonAlpha Institute for Biotechnology, Huntsville, Alabama, USA. Lindsay Waite & Devin Absher Information Management Services, Inc., Rockville, Maryland, USA. William Wheeler Department of Biological Psychology, VU University Amsterdam and Institute for Health and Care Research (EMGO+), VU Medical Center, Amsterdam, The Netherlands. Harmen H M Draisma, Eco J C de Geus, Jouke-Jan Hottenga, Gonneke Willemsen & Dorret I Boomsma Division of Statistical Genomics, Washington University School of Medicine, St. Louis, Missouri, USA. Mary F Feitosa, Shamika Ketkar & Ingrid B Borecki Department of Biostatistics, University of Washington, Seattle, Washington, USA. Kathleen F Kerr, Quenna Wong & Richard A Kronmal Quantitative Genetics Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia. Penelope A Lind & Sarah E Medland Complex Genetics Section, Department of Medical Genetics-de Bakker Group, University Medical Center Utrecht, Utrecht, The Netherlands. N Charlotte Onland-Moret Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands. N Charlotte Onland-Moret, Paul I W de Bakker, Maarten Leusink & Yvonne T van der Schouw Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. Ci Song, Erik Ingelsson & Nancy L Pedersen Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, UK. Michael N Weedon & Weijia Xie Centre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche (UMR) 8199, Institut Pasteur de Lille, Lille, France. Loic Yengo, Nabila Bouatia-Naji & Philippe Froguel Division of Preventive Medicine, Cardiovascular Division, Brigham and Women's Hospital, Boston, Massachusetts, USA. Christine M Albert Harvard Medical School, Boston, Massachusetts, USA. Christine M Albert & Patrick T Ellinor Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA. Alvaro Alonso Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. Dan E Arking McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. Dan E Arking Department of Medicine, Division of Genetics, Brigham and Women's Hospital, Boston, Massachusetts, USA. Paul I W de Bakker Department of Medical Genetics, Division of Biomedical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands. Paul I W de Bakker Institut National de la Santé et de la Recherche Médicale (INSERM), CESP Centre for Research in Epidemiology and Population Health, U1018, Epidemiology of Diabetes, Obesity and Chronic Kidney Disease over the Lifecourse, Villejuif, France. Beverley Balkau UMRS 1018, Université Paris-Sud 11, Villejuif, France. Beverley Balkau Department of Health Sciences, Milan University and Filarete Foundation, Milan, Italy. Cristina Barlassina & Daniele Cusi Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, USA. Joshua C Bis, Susan R Heckbert, Bruce M Psaty & Nona Sotoodehnia Department of Medicine, University of Washington, Seattle, Washington, USA. Joshua C Bis & Bruce M Psaty Lille Nord de France University, Lille, France. Nabila Bouatia-Naji & Philippe Froguel INSERM U970, Paris Cardiovascular Research Centre, Hopital Européen Georges Pampidou, Paris, France. Nabila Bouatia-Naji Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, Maryland, USA. Stephen J Chanock & Demetrius Albanes Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, Maryland, USA. Stephen J Chanock National Human Genome Research Institute, US National Institutes of Health, Bethesda, Maryland, USA. Peter S Chines Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio, USA. Mina Chung Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA. Mina Chung Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA. Dawood Darbar INSERM U1087, CNRS U6291 and University of Nantes, l'Institut du Thorax, Nantes, France. Christian Dina Centre Hospitalier Universitaire (CHU) Nantes, l'Institut du Thorax, Nantes, France. Christian Dina Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany. Marcus Dörr & Stephan B Felix DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany. Marcus Dörr & Stephan B Felix Icelandic Heart Association Research Institute, Kopavogur, Iceland. Vilmundur Gudnason & Albert V Smith University of Iceland, Reykjavik, Iceland. Vilmundur Gudnason Laboratory for Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland, USA. Tamara B Harris Department of Clinical Sciences, Obstetrics and Gynecology, University of Oulu, Oulu, Finland. Anna-Liisa Hartikainen & Anneli Pouta Department of Epidemiology, University of Washington, Seattle, Washington, USA. Susan R Heckbert & Bruce M Psaty Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy (affiliated institute of the University of Lübeck). Andrew A Hicks, Peter P Pramstaller & Jeanette Erdmann Netherlands Genomics Initiative-sponsored Netherlands Consortium for Healthy Ageing, Rotterdam, The Netherlands. Albert Hofman, André G Uitterlinden, Jacqueline C M Witteman & Bruno H Ch Stricker Department of General Internal Medicine, Division of Vascular Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. Suzanne Holewijn & Jacqueline de Graaf Nyken, Groningen, The Netherlands. Femke Hoogstra-Berends Uppsala Clinical Research Center, Uppsala University Hospital, Uppsala, Sweden. Åsa Johansson Division of Cardiology, Miller School of Medicine, University of Miami, Miami, Florida, USA. Juhani Junttila Institute of Clinical Medicine, Department of Internal Medicine, University of Oulu, Oulu, Finland. Juhani Junttila & Heikki V Huikuri Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians- Universität, Munich, Germany. Stefan Kääb & Martina Müller-Nurasyid Munich Heart Alliance, Munich, Germany. Stefan Kääb & Annette Peters Department of Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. Bart Kanon & Ody C M Sibon Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK. Kay-Tee Khaw & Robert N Luben Department of Medicine, Stanford University School of Medicine, Stanford, California, USA. Joshua W Knowles, Thomas Quertermous & Themistocles L Assimes Cardiology Department, Ealing Hospital National Health Service (NHS) Trust, London, UK. Angrad S Kooner, Jaban S Sehmi, John C Chambers & Jaspal S Kooner Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands. Jan A Kors & Bruno H Ch Stricker Genetic Epidemiology Group, Department of Epidemiology and Public Health, University College London, London, UK. Meena Kumari, Aroon Hingorani & Mika Kivimaki National Public Health Institute, Biomedicum Helsinki, Helsinki, Finland. Päivi Laiho Laboratory of Cardiovascular Science, National Institute on Aging, Baltimore, Maryland, USA. Edward G Lakatta & Kirill V Tarasov Division Pharmacoepidemiology & Clinical Pharmacology, Utrecht University, Utrecht, The Netherlands. Maarten Leusink Department of Epidemiology & Prevention, Division of Public Health Sciences, Wake Forest University, Winston-Salem, North Carolina, USA. Yongmei Liu Department of Biostatistics, School of Public Health, Boston University, Boston, Massachusetts, USA. Kathryn L Lunetta National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, USA. Kathryn L Lunetta, Christopher J O'Donnell, Shih-Jen Hwang & Christopher Newton-Cheh Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany. Marcello R P Markus Institut Universitaire de Médecine Sociale et Préventive (IUMSP), Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne, Lausanne, Switzerland. Pedro Marques-Vidal School of Social and Community Medicine, University of Bristol, Bristol, UK. Wendy L McArdle & Susan M Ring Molecular Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia. Grant W Montgomery Human Genetics Center, University of Texas Health Science Center, Houston, Texas, USA. Alanna C Morrison Chair of Genetic Epidemiology, Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany. Martina Müller-Nurasyid Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. Martina Müller-Nurasyid Department of Medical Genetics and Development, University of Geneva Medical School, Geneva, Switzerland. Mari Nelis Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts, USA. Christopher J O'Donnell National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA. Christopher J O'Donnell MRC Unit for Lifelong Health and Ageing, London, UK. Ken K Ong, Andrew Wong & Diana Kuh Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. Anne B Newman Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. Annette Peters Department of Public Health, Faculty of Medicine, University of Split, Split, Croatia. Ozren Polasek National Institute for Health and Welfare, Oulu, Finland. Anneli Pouta & Marjo-Riitta Jarvelin Department of Neurology, General Central Hospital, Bolzano, Italy. Peter P Pramstaller Department of Neurology, University of Lübeck, Lübeck, Germany. Peter P Pramstaller Group Health Research Institute, Seattle, Washington, USA. Bruce M Psaty Department of Health Services, University of Washington, Seattle, Washington, USA. Bruce M Psaty Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, USA. Dabeeru C Rao Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts, USA. Harvard Biological and Biomedical Sciences Program, Harvard University, Boston, Massachusetts, USA. Health Science and Technology M.D. Program, Harvard University and Massachusetts Institute of Technology, Boston, Massachusetts, USA. Department of Pathophysiology, Faculty of Medicine, University of Split, Split, Croatia. Diana Rudan Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Italy. Serena Sanna National Heart and Lung Institute, Imperial College London, London, UK. Jaban S Sehmi & Jaspal S Kooner Laboratory of Neurogenetics, National Institute on Aging, Bethesda, Maryland, USA. Andrew B Singleton Department of Twin Research and Genetic Epidemiology Unit, St. Thomas' Campus, King's College London, St. Thomas' Hospital, London, UK. Nicole Soranzo, Tim D Spector & Yalda Jamshidi Biology Department, Boston College, Chestnut Hill, Massachusetts, USA. Chip Stewart Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands. André G Uitterlinden & Bruno H Ch Stricker Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia. John B Whitfield & Nicholas G Martin Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK. Sarah H Wild, James F Wilson & Igor Rudan Division of Biomedical Sciences, St. George's University of London, London, UK. Yalda Jamshidi Department of Physiatrics, Lapland Central Hospital, Rovaniemi, Finland. Paavo Zitting Centre for Nutrition, Prevention and Health Services, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands. Jolanda M A Boer & W M Monique Verschuren Department of Sports Medicine, Norwegian School of Sport Sciences, Oslo, Norway. Ulf Ekelund Genomic Medicine, Hammersmith Hospital, Imperial College London, London, UK. Philippe Froguel Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. Erik Ingelsson Department of Medical Sciences, Uppsala University, Akademiska Sjukhuset, Uppsala, Sweden. Lars Lind Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands. Ben A Oostra Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA. Jerome I Rotter Institue of Cellular Medicine, Newcastle University, Newcastle, UK. Mark Walker Department of Medicine, Landspitali University Hospital, Reykjavik, Iceland. David O Arnar Faculty of Medicine, University of Iceland, Reykjavik, Iceland. David O Arnar, Unnur Thorsteinsdottir & Kari Stefansson Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy. Stefania Bandinelli Channing Laboratory and Renal Division, Brigham and Women's Hospital, Boston, Massachusetts, USA. Gary Curhan Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA. Gary Curhan Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland. Johan Eriksson Folkhälsan Research Centre, Helsinki, Finland. Johan Eriksson & Bo Isomaa Unit of General Practice, Helsinki University Central Hospital, Helsinki, Finland. Johan Eriksson Hypertension and Related Diseases Centre-Azienda Ospedaliero Universitaria (AOU), University of Sassari, Sassari, Italy. Nicola Glorioso Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. David J Hunter & Peter Kraft Division of Research, Kaiser Permanente of Northern California, Oakland, California, USA. Carlos Iribarren Department of Social Services and Health Care, Jakobstad, Finland. Bo Isomaa Biocenter Oulu, University of Oulu, Oulu, Finland. Marjo-Riitta Jarvelin Institute of Health Sciences, University of Oulu, Oulu, Finland. Marjo-Riitta Jarvelin Department of Chronic Disease Prevention, National Institute for Health and Welfare, Turku, Finland. Antti Jula Department of Clinical Chemistry, University of Tampere and Tampere University Hospital, Tampere, Finland. Mika Kähönen & Terho Lehtimäki Department for Health Evidence, Radboud University Medical Centre, Nijmegen, The Netherlands. Lambertus A Kiemeney Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. Lambertus A Kiemeney Department of Endocrinology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. Melanie M van der Klauw Laboratory of Genetic and Environmental Epidemiology, Fondazione di Ricerca e Cura Giovanni Paolo II, Catholic University, Campobasso, Italy. Licia Iacoviello Transplantation Laboratory, Haartman Institute, University of Helsinki, Helsinki, Finland. Marja-Liisa L Lokki Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. Gerjan Navis Department of Medicine, Division of Cardiology, Helsinki University Central Hospital, Helsinki, Finland. Markku S Nieminen & Juha Sinisalo International Centre for Circulatory Health (ICCH), Imperial College London, London, UK. Neil R Poulter & Peter S Sever Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland. Olli T Raitakari Department of Clinical Physiology and Nuclear Medicine, University of Turku and Turku University Hospital, Turku, Finland. Olli T Raitakari Kos Genetic, Milan, Italy. Federica Rizzi Complex and Adaptive Systems Laboratory, University College Dublin, Belfield, Dublin, Ireland. Denis C Shields Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin, Ireland. Denis C Shields School of Medicine and Medical Sciences, University College Dublin, Belfield, Dublin, Ireland. Denis C Shields Geriatric Research and Education Clinical Center, Veterans Administration Medical Center, Baltimore, Maryland, USA. Alan R Shuldiner Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland. Alice V Stanton Diabetes Unit, National Institute for Health and Welfare, Helsinki, Finland. Jaako Tuomilehto Centre for Vascular Prevention, Danube-University Krems, Krems, Austria. Jaako Tuomilehto Red Temática de Investigación Cooperativa en Enfermedades Cardiovasculares (Red RECAVA), Grupo RD06/0014/0015, Hospital Universitario La Paz, Madrid, Spain. Jaako Tuomilehto King Abdulaziz University, Jeddah, Saudi Arabia. Jaako Tuomilehto Department of Medicine, University of Turku and Turku University Hospital, Turku, Finland. Jorma Viikari Department of Internal Medicine, University Hospital of Lausanne, Lausanne, Switzerland. Peter Vollenweider & Gérard Waeber Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland. Elisabeth Widen Department of Biomedical Science, Hallym University, Chuncheon, Korea. Yoon Shin Cho Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia. Peter M Visscher Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA. Cristen Willer Blizard Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. Lude Franke A full list of members appears in the Supplementary Note. $affiliationAuthor Institute for Integrative and Experimental Genomics, University of Lübeck, Lübeck, Germany. Jeanette Erdmann DZHK, partner site Hamburg/Kiel/Lübeck, Lübeck, Germany. Jeanette Erdmann Department of Health Sciences, University of Leicester, Leicester, UK. John R Thompson Institute of Human Genetics, Helmholtz Zentrum München-German Research Center for Environmental Health, Munich, Germany. Arne Pfeufer Institute of Human Genetics, Klinikum Rechts der Isar der Technischen Universitat München, Munich, Germany. Arne Pfeufer Department????????????????? ????????2êaffiliazioni???? CNR ISPAAM??2ëaffiliazioni???u0Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK. Marcel den Hoed, Jing Hua Zhao, Jian'an Luan, Søren Brage, Claudia Langenberg, Ken K Ong, Robert A Scott, Stephen Sharp, Ulf Ekelund, Nita G Forouhi, Nicholas J Wareham & Ruth J F Loos Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden. Marcel den Hoed & Erik Ingelsson Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands. Mark Eijgelsheim, Aaron Isaacs, Albert Hofman, André G Uitterlinden, Jacqueline C M Witteman, Cornelia M van Duijn & Bruno H Ch Stricker Estonian Biocenter, Tartu, Estonia. Tõnu Esko, Evelin Mihailov, Mari Nelis & Andres Metspalu Estonian Genome Center, University of Tartu, Tartu, Estonia. Krista Fischer, Lili Milani, Mari Nelis, Andres Metspalu & Markus Perola Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia. Evelin Mihailov & Andres Metspalu Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. Bianca J J M Brundel & Femke Hoogstra-Berends Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA. David S Peal, Stacey N Lynch, Jordan T Shin & David J Milan MRC Centre for Causal Analyses in Translational Epidemiology (CAiTE), School of Social and Community Medicine, University of Bristol, Bristol, UK. David M Evans, John P Kemp, Beate St. Pourcain, Nicholas J Timpson & George Davey Smith Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. Ilja M Nolte, Ronald P Stolk & Harold Snieder Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, USA. Ayellet V Segrè Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA. Ayellet V Segrè, Robert E Handsaker, Paul I W de Bakker, Steven A McCarroll & Christopher Newton-Cheh deCODE Genetics, Reykjavik, Iceland. Hilma Holm, Daniel Gudbjartsson, Unnur Thorsteinsdottir & Kari Stefansson Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA. Robert E Handsaker & Steven A McCarroll Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. Harm-Jan Westra, Cisca Wijmenga & Lude Franke Clinical Pharmacology, National Institute for Health Research (NIHR) Cardiovascular Biomedical Research Unit, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. Toby Johnson, W L Mark Caulfield & Patricia B Munroe Genome Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. Toby Johnson, W L Mark Caulfield & Patricia B Munroe Centre for Medical Systems Biology, Leiden, The Netherlands. Aaron Isaacs & Cornelia M van Duijn Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK. Jian Yang & Nicole Soranzo Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA. Alicia Lundby, Sarah E Medland, Elizabeth J Rossin & Chip Stewart The Danish National Research Foundation Centre for Cardiac Arrhythmia, Copenhagen, Denmark. Novo Nordisk Foundation Center for Protein Research, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark. Jesper V Olsen Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Daejeon, The Republic of Korea. Young Jin Kim & Min Jin Go Department of Clinical Sciences, Diabetes and Endocrinology, Lund University and Lund University Diabetes Centre, Malmö, Sweden. Peter Almgren, Claes Ladenvall & Leif Groop Community Prevention Unit, Institute of Social and Preventive Medicine, Lausanne University Hospital, Lausanne, Switzerland. Murielle Bochud Université de Montréal, Montreal, Quebec, Canada. Gabrielle Boucher, Philippe Goyette, John D Rioux & Jean-Claude Tardif Montreal Heart Institute, Montreal, Quebec, Canada. Gabrielle Boucher, Philippe Goyette, John D Rioux & Jean-Claude Tardif Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA. Marilyn C Cornelis, Majken K Jensen, Frank B Hu, Lu Qi & Eric B Rimm Division of Population Health Sciences and Education, St. George's, University of London, London, UK. David Hadley & David P Strachan Pediatric Epidemiology Center, University of South Florida, Tampa, Florida, USA. David Hadley Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. Pim van der Harst, Irene Mateo Leach, Rudolf A de Boer, Wiek H van Gilst & Dirk J van Veldhuisen MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK. Caroline Hayward, Veronique Vitart & Pau Navarro Department of Internal Medicine, VU Medical Center, Amsterdam, The Netherlands. Martin den Heijer Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden. Wilmar Igl, Åsa Johansson & Ulf Gyllensten Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA. Anne U Jackson, Christian Fuchsberger, Heather M Stringham & Michael Boehnke Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA. Anne U Jackson, Heather M Stringham & Michael Boehnke Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland. Zoltán Kutalik, Paola Benaglio & Jacques S Beckmann Swiss Institute of Bioinformatics, Lausanne, Switzerland. Zoltán Kutalik The Institute of Molecular Medicine, University of Helsinki, Helsinki, Finland. Kati Kristiansson, Perttu Salo & Markus Perola Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland. Kati Kristiansson Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. Mattias Lorentzon, Liesbeth Vandenput & Claes Ohlsson Department of Medicine, Division of Endocrinology, Diabetes and Nutrition, University of Maryland, School of Medicine, Baltimore, Maryland, USA. May E Montasser, Jeffrey R O'Connell, Braxton D Mitchell & Alan R Shuldiner Department of Medicine, Institute for Human Genetics, University of California, San Francisco, San Francisco, California, USA. Omer T Njajou & Wen-Chi Hsueh Department of Epidemiology and Biostatistics, Imperial College London, London, UK. Paul F O'Reilly, Weihua Zhang, Paul Elliott, Kathryn A Miller, John C Chambers & Marjo-Riitta Jarvelin MRC-Health Protection Agency (MRC-HPA) Centre for Environment and Health, Imperial College London, London, UK. Paul F O'Reilly, Paul Elliott & Marjo-Riitta Jarvelin Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK. Sandosh Padmanabhan Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA. Tuomo Rankinen & Claude Bouchard Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland. Perttu Salo, Aki S Havulinna, Johan Eriksson, Veikko Salomaa, Jarmo Virtamo & Markus Perola Clinical Research Branch, National Institute on Aging, Baltimore, Maryland, USA. Toshiko Tanaka & Luigi Ferrucci HudsonAlpha Institute for Biotechnology, Huntsville, Alabama, USA. Lindsay Waite & Devin Absher Information Management Services, Inc., Rockville, Maryland, USA. William Wheeler Department of Biological Psychology, VU University Amsterdam and Institute for Health and Care Research (EMGO+), VU Medical Center, Amsterdam, The Netherlands. Harmen H M Draisma, Eco J C de Geus, Jouke-Jan Hottenga, Gonneke Willemsen & Dorret I Boomsma Division of Statistical Genomics, Washington University School of Medicine, St. Louis, Missouri, USA. Mary F Feitosa, Shamika Ketkar & Ingrid B Borecki Department of Biostatistics, University of Washington, Seattle, Washington, USA. Kathleen F Kerr, Quenna Wong & Richard A Kronmal Quantitative Genetics Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia. Penelope A Lind & Sarah E Medland Complex Genetics Section, Department of Medical Genetics-de Bakker Group, University Medical Center Utrecht, Utrecht, The Netherlands. N Charlotte Onland-Moret Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands. N Charlotte Onland-Moret, Paul I W de Bakker, Maarten Leusink & Yvonne T van der Schouw Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. Ci Song, Erik Ingelsson & Nancy L Pedersen Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, UK. Michael N Weedon & Weijia Xie Centre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche (UMR) 8199, Institut Pasteur de Lille, Lille, France. Loic Yengo, Nabila Bouatia-Naji & Philippe Froguel Division of Preventive Medicine, Cardiovascular Division, Brigham and Women's Hospital, Boston, Massachusetts, USA. Christine M Albert Harvard Medical School, Boston, Massachusetts, USA. Christine M Albert & Patrick T Ellinor Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA. Alvaro Alonso Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. Dan E Arking McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. Dan E Arking Department of Medicine, Division of Genetics, Brigham and Women's Hospital, Boston, Massachusetts, USA. Paul I W de Bakker Department of Medical Genetics, Division of Biomedical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands. Paul I W de Bakker Institut National de la Santé et de la Recherche Médicale (INSERM), CESP Centre for Research in Epidemiology and Population Health, U1018, Epidemiology of Diabetes, Obesity and Chronic Kidney Disease over the Lifecourse, Villejuif, France. Beverley Balkau UMRS 1018, Université Paris-Sud 11, Villejuif, France. Beverley Balkau Department of Health Sciences, Milan University and Filarete Foundation, Milan, Italy. Cristina Barlassina & Daniele Cusi Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, USA. Joshua C Bis, Susan R Heckbert, Bruce M Psaty & Nona Sotoodehnia Department of Medicine, University of Washington, Seattle, Washington, USA. Joshua C Bis & Bruce M Psaty Lille Nord de France University, Lille, France. Nabila Bouatia-Naji & Philippe Froguel INSERM U970, Paris Cardiovascular Research Centre, Hopital Européen Georges Pampidou, Paris, France. Nabila Bouatia-Naji Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, Maryland, USA. Stephen J Chanock & Demetrius Albanes Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, Maryland, USA. Stephen J Chanock National Human Genome Research Institute, US National Institutes of Health, Bethesda, Maryland, USA. Peter S Chines Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio, USA. Mina Chung Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA. Mina Chung Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA. Dawood Darbar INSERM U1087, CNRS U6291 and University of Nantes, l'Institut du Thorax, Nantes, France. Christian Dina Centre Hospitalier Universitaire (CHU) Nantes, l'Institut du Thorax, Nantes, France. Christian Dina Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany. Marcus Dörr & Stephan B Felix DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany. Marcus Dörr & Stephan B Felix Icelandic Heart Association Research Institute, Kopavogur, Iceland. Vilmundur Gudnason & Albert V Smith University of Iceland, Reykjavik, Iceland. Vilmundur Gudnason Laboratory for Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland, USA. Tamara B Harris Department of Clinical Sciences, Obstetrics and Gynecology, University of Oulu, Oulu, Finland. Anna-Liisa Hartikainen & Anneli Pouta Department of Epidemiology, University of Washington, Seattle, Washington, USA. Susan R Heckbert & Bruce M Psaty Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy (affiliated institute of the University of Lübeck). Andrew A Hicks, Peter P Pramstaller & Jeanette Erdmann Netherlands Genomics Initiative-sponsored Netherlands Consortium for Healthy Ageing, Rotterdam, The Netherlands. Albert Hofman, André G Uitterlinden, Jacqueline C M Witteman & Bruno H Ch Stricker Department of General Internal Medicine, Division of Vascular Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. Suzanne Holewijn & Jacqueline de Graaf Nyken, Groningen, The Netherlands. Femke Hoogstra-Berends Uppsala Clinical Research Center, Uppsala University Hospital, Uppsala, Sweden. Åsa Johansson Division of Cardiology, Miller School of Medicine, University of Miami, Miami, Florida, USA. Juhani Junttila Institute of Clinical Medicine, Department of Internal Medicine, University of Oulu, Oulu, Finland. Juhani Junttila & Heikki V Huikuri Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians- Universität, Munich, Germany. Stefan Kääb & Martina Müller-Nurasyid Munich Heart Alliance, Munich, Germany. Stefan Kääb & Annette Peters Department of Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. Bart Kanon & Ody C M Sibon Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK. Kay-Tee Khaw & Robert N Luben Department of Medicine, Stanford University School of Medicine, Stanford, California, USA. Joshua W Knowles, Thomas Quertermous & Themistocles L Assimes Cardiology Department, Ealing Hospital National Health Service (NHS) Trust, London, UK. Angrad S Kooner, Jaban S Sehmi, John C Chambers & Jaspal S Kooner Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands. Jan A Kors & Bruno H Ch Stricker Genetic Epidemiology Group, Department of Epidemiology and Public Health, University College London, London, UK. Meena Kumari, Aroon Hingorani & Mika Kivimaki National Public Health Institute, Biomedicum Helsinki, Helsinki, Finland. Päivi Laiho Laboratory of Cardiovascular Science, National Institute on Aging, Baltimore, Maryland, USA. Edward G Lakatta & Kirill V Tarasov Division Pharmacoepidemiology & Clinical Pharmacology, Utrecht University, Utrecht, The Netherlands. Maarten Leusink Department of Epidemiology & Prevention, Division of Public Health Sciences, Wake Forest University, Winston-Salem, North Carolina, USA. Yongmei Liu Department of Biostatistics, School of Public Health, Boston University, Boston, Massachusetts, USA. Kathryn L Lunetta National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, USA. Kathryn L Lunetta, Christopher J O'Donnell, Shih-Jen Hwang & Christopher Newton-Cheh Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany. Marcello R P Markus Institut Universitaire de Médecine Sociale et Préventive (IUMSP), Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne, Lausanne, Switzerland. Pedro Marques-Vidal School of Social and Community Medicine, University of Bristol, Bristol, UK. Wendy L McArdle & Susan M Ring Molecular Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia. Grant W Montgomery Human Genetics Center, University of Texas Health Science Center, Houston, Texas, USA. Alanna C Morrison Chair of Genetic Epidemiology, Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany. Martina Müller-Nurasyid Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. Martina Müller-Nurasyid Department of Medical Genetics and Development, University of Geneva Medical School, Geneva, Switzerland. Mari Nelis Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts, USA. Christopher J O'Donnell National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA. Christopher J O'Donnell MRC Unit for Lifelong Health and Ageing, London, UK. Ken K Ong, Andrew Wong & Diana Kuh Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. Anne B Newman Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. Annette Peters Department of Public Health, Faculty of Medicine, University of Split, Split, Croatia. Ozren Polasek National Institute for Health and Welfare, Oulu, Finland. Anneli Pouta & Marjo-Riitta Jarvelin Department of Neurology, General Central Hospital, Bolzano, Italy. Peter P Pramstaller Department of Neurology, University of Lübeck, Lübeck, Germany. Peter P Pramstaller Group Health Research Institute, Seattle, Washington, USA. Bruce M Psaty Department of Health Services, University of Washington, Seattle, Washington, USA. Bruce M Psaty Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, USA. Dabeeru C Rao Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts, USA. Harvard Biological and Biomedical Sciences Program, Harvard University, Boston, Massachusetts, USA. Health Science and Technology M.D. Program, Harvard University and Massachusetts Institute of Technology, Boston, Massachusetts, USA. Department of Pathophysiology, Faculty of Medicine, University of Split, Split, Croatia. Diana Rudan Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Italy. Serena Sanna National Heart and Lung Institute, Imperial College London, London, UK. Jaban S Sehmi & Jaspal S Kooner Laboratory of Neurogenetics, National Institute on Aging, Bethesda, Maryland, USA. Andrew B Singleton Department of Twin Research and Genetic Epidemiology Unit, St. Thomas' Campus, King's College London, St. Thomas' Hospital, London, UK. Nicole Soranzo, Tim D Spector & Yalda Jamshidi Biology Department, Boston College, Chestnut Hill, Massachusetts, USA. Chip Stewart Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands. André G Uitterlinden & Bruno H Ch Stricker Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia. John B Whitfield & Nicholas G Martin Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK. Sarah H Wild, James F Wilson & Igor Rudan Division of Biomedical Sciences, St. George's University of London, London, UK. Yalda Jamshidi Department of Physiatrics, Lapland Central Hospital, Rovaniemi, Finland. Paavo Zitting Centre for Nutrition, Prevention and Health Services, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands. Jolanda M A Boer & W M Monique Verschuren Department of Sports Medicine, Norwegian School of Sport Sciences, Oslo, Norway. Ulf Ekelund Genomic Medicine, Hammersmith Hospital, Imperial College London, London, UK. Philippe Froguel Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. Erik Ingelsson Department of Medical Sciences, Uppsala University, Akademiska Sjukhuset, Uppsala, Sweden. Lars Lind Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands. Ben A Oostra Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA. Jerome I Rotter Institue of Cellular Medicine, Newcastle University, Newcastle, UK. Mark Walker Department of Medicine, Landspitali University Hospital, Reykjavik, Iceland. David O Arnar Faculty of Medicine, University of Iceland, Reykjavik, Iceland. David O Arnar, Unnur Thorsteinsdottir & Kari Stefansson Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy. Stefania Bandinelli Channing Laboratory and Renal Division, Brigham and Women's Hospital, Boston, Massachusetts, USA. Gary Curhan Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA. Gary Curhan Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland. Johan Eriksson Folkhälsan Research Centre, Helsinki, Finland. Johan Eriksson & Bo Isomaa Unit of General Practice, Helsinki University Central Hospital, Helsinki, Finland. Johan Eriksson Hypertension and Related Diseases Centre-Azienda Ospedaliero Universitaria (AOU), University of Sassari, Sassari, Italy. Nicola Glorioso Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. David J Hunter & Peter Kraft Division of Research, Kaiser Permanente of Northern California, Oakland, California, USA. Carlos Iribarren Department of Social Services and Health Care, Jakobstad, Finland. Bo Isomaa Biocenter Oulu, University of Oulu, Oulu, Finland. Marjo-Riitta Jarvelin Institute of Health Sciences, University of Oulu, Oulu, Finland. Marjo-Riitta Jarvelin Department of Chronic Disease Prevention, National Institute for Health and Welfare, Turku, Finland. Antti Jula Department of Clinical Chemistry, University of Tampere and Tampere University Hospital, Tampere, Finland. Mika Kähönen & Terho Lehtimäki Department for Health Evidence, Radboud University Medical Centre, Nijmegen, The Netherlands. Lambertus A Kiemeney Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. Lambertus A Kiemeney Department of Endocrinology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. Melanie M van der Klauw Laboratory of Genetic and Environmental Epidemiology, Fondazione di Ricerca e Cura Giovanni Paolo II, Catholic University, Campobasso, Italy. Licia Iacoviello Transplantation Laboratory, Haartman Institute, University of Helsinki, Helsinki, Finland. Marja-Liisa L Lokki Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. Gerjan Navis Department of Medicine, Division of Cardiology, Helsinki University Central Hospital, Helsinki, Finland. Markku S Nieminen & Juha Sinisalo International Centre for Circulatory Health (ICCH), Imperial College London, London, UK. Neil R Poulter & Peter S Sever Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland. Olli T Raitakari Department of Clinical Physiology and Nuclear Medicine, University of Turku and Turku University Hospital, Turku, Finland. Olli T Raitakari Kos Genetic, Milan, Italy. Federica Rizzi Complex and Adaptive Systems Laboratory, University College Dublin, Belfield, Dublin, Ireland. Denis C Shields Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin, Ireland. Denis C Shields School of Medicine and Medical Sciences, University College Dublin, Belfield, Dublin, Ireland. Denis C Shields Geriatric Research and Education Clinical Center, Veterans Administration Medical Center, Baltimore, Maryland, USA. Alan R Shuldiner Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland. Alice V Stanton Diabetes Unit, National Institute for Health and Welfare, Helsinki, Finland. Jaako Tuomilehto Centre for Vascular Prevention, Danube-University Krems, Krems, Austria. Jaako Tuomilehto Red Temática de Investigación Cooperativa en Enfermedades Cardiovasculares (Red RECAVA), Grupo RD06/0014/0015, Hospital Universitario La Paz, Madrid, Spain. Jaako Tuomilehto King Abdulaziz University, Jeddah, Saudi Arabia. Jaako Tuomilehto Department of Medicine, University of Turku and Turku University Hospital, Turku, Finland. Jorma Viikari Department of Internal Medicine, University Hospital of Lausanne, Lausanne, Switzerland. Peter Vollenweider & Gérard Waeber Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland. Elisabeth Widen Department of Biomedical Science, Hallym University, Chuncheon, Korea. Yoon Shin Cho Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia. Peter M Visscher Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA. Cristen Willer Blizard Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. Lude Franke A full list of members appears in the Supplementary Note. $affiliationAuthor Institute for Integrative and Experimental Genomics, University of Lübeck, Lübeck, Germany. Jeanette Erdmann DZHK, partner site Hamburg/Kiel/Lübeck, Lübeck, Germany. Jeanette Erdmann Department of Health Sciences, University of Leicester, Leicester, UK. John R Thompson Institute of Human Genetics, Helmholtz Zentrum München-German Research Center for Environmental Health, Munich, Germany. Arne Pfeufer Institute of Human Genetics, Klinikum Rechts der Isar der Technischen Universitat München, Munich, Germany. A (literal)
Titolo
  • Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. (literal)
Abstract
  • Elevated resting heart rate is associated with greater risk of cardiovascular disease and mortality. In a 2-stage meta-analysis of genome-wide association studies in up to 181,171 individuals, we identified 14 new loci associated with heart rate and confirmed associations with all 7 previously established loci. Experimental downregulation of gene expression in Drosophila melanogaster and Danio rerio identified 20 genes at 11 loci that are relevant for heart rate regulation and highlight a role for genes involved in signal transmission, embryonic cardiac development and the pathophysiology of dilated cardiomyopathy, congenital heart failure and/or sudden cardiac death. In addition, genetic susceptibility to increased heart rate is associated with altered cardiac conduction and reduced risk of sick sinus syndrome, and both heart rate-increasing and heart rate-decreasing variants associate with risk of atrial fibrillation. Our findings provide fresh insights into the mechanisms regulating heart rate and identify new therapeutic targets (literal)
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