Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. (Articolo in rivista)

Type
Label
  • Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. (Articolo in rivista) (literal)
Anno
  • 2013-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1038/ng.2606 (literal)
Alternative label
  • Berndt SI, Gustafsson S, Mägi R, Ganna A, Wheeler E, Feitosa MF, Justice AE, Monda KL, Croteau-Chonka DC, Day FR, Esko T, Fall T, Ferreira T, Gentilini D, Jackson AU, Luan J, Randall JC, Vedantam S, Willer CJ, Winkler TW, Wood AR, Workalemahu T, Hu YJ, Lee SH, Liang L, Lin DY, Min JL, Neale BM, Thorleifsson G, Yang J, Albrecht E, Amin N, Bragg-Gresham JL, Cadby G, den Heijer M, Eklund N, Fischer K, Goel A, Hottenga JJ, Huffman JE, Jarick I, Johansson Å, Johnson T, Kanoni S, Kleber ME, König IR, Kristiansson K, Kutalik Z, Lamina C, Lecoeur C, Li G, Mangino M, McArdle WL, Medina-Gomez C, Müller-Nurasyid M, Ngwa JS, Nolte IM, Paternoster L, Pechlivanis S, Perola M, Peters MJ, Preuss M, Rose LM, Shi J, Shungin D, Smith AV, Strawbridge RJ, Surakka I, Teumer A, Trip MD, Tyrer J, Van Vliet-Ostaptchouk JV, Vandenput L, Waite LL, Zhao JH, Absher D, Asselbergs FW, Atalay M, Attwood AP, Balmforth AJ, Basart H, Beilby J, Bonnycastle LL, Brambilla P, Bruinenberg M, Campbell H, Chasman DI, Chines PS, Collins FS, Connell JM, Cookson WO, de Faire U, de Vegt F, Dei M, Dimitriou M, Edkins S, Estrada K, Evans DM, Farrall M, Ferrario MM, Ferrières J, Franke L, Frau F, Gejman PV, Grallert H, Grönberg H, Gudnason V, Hall AS, Hall P, Hartikainen AL, Hayward C, Heard-Costa NL, Heath AC, Hebebrand J, Homuth G, Hu FB, Hunt SE, Hyppönen E, Iribarren C, Jacobs KB, Jansson JO, Jula A, Kähönen M, Kathiresan S, Kee F, Khaw KT, Kivimäki M, Koenig W, Kraja AT, Kumari M, Kuulasmaa K, Kuusisto J, Laitinen JH, Lakka TA, Langenberg C, Launer LJ, Lind L, Lindström J, Liu J, Liuzzi A, Lokki ML, Lorentzon M, Madden PA, Magnusson PK, Manunta P, Marek D, März W, Mateo Leach I, McKnight B, Medland SE, Mihailov E, Milani L, Montgomery GW, Mooser V, Mühleisen TW, Munroe PB, Musk AW, Narisu N, Navis G, Nicholson G, Nohr EA, Ong KK, Oostra BA, Palmer CN, Palotie A, Peden JF, Pedersen N, Peters A, Polasek O, Pouta A, Pramstaller PP, Prokopenko I, Pütter C, Radhakrishnan A, Raitakari O, Rendon A, Rivadeneira F, Rudan I, Saaristo TE, Sambrook JG, Sanders AR, Sanna S, Saramies J, Schipf S, Schreiber S, Schunkert H, Shin SY, Signorini S, Sinisalo J, Skrobek B, Soranzo N, Stan?áková A, Stark K, Stephens JC, Stirrups K, Stolk RP, Stumvoll M, Swift AJ, Theodoraki EV, Thorand B, Tregouet DA, Tremoli E, Van der Klauw MM, van Meurs JB, Vermeulen SH, Viikari J, Virtamo J, Vitart V, Waeber G, Wang Z, Widén E, Wild SH, Willemsen G, Winkelmann BR, Witteman JC, Wolffenbuttel BH, Wong A, Wright AF, Zillikens MC, Amouyel P, Boehm BO, Boerwinkle E, Boomsma DI, Caulfield MJ, Chanock SJ, Cupples LA, Cusi D, Dedoussis GV, Erdmann J, Eriksson JG, Franks PW, Froguel P, Gieger C, Gyllensten U, Hamsten A, Harris TB, Hengstenberg C, Hicks AA, Hingorani A, Hinney A, Hofman A, Hovingh KG, Hveem K, Illig T, Jarvelin MR, Jöckel KH, Keinanen-Kiukaanniemi SM, Kiemeney LA, Kuh D, Laakso M, Lehtimäki T, Levinson DF, Martin NG, Metspalu A, Morris AD, Nieminen MS, Njølstad I, Ohlsson C, Oldehinkel AJ, Ouwehand WH, Palmer LJ, Penninx B, Power C, Province MA, Psaty BM, Qi L, Rauramaa R, Ridker PM, Ripatti S, Salomaa V, Samani NJ, Snieder H, Sørensen TI, Spector TD, Stefansson K, Tönjes A, Tuomilehto J, Uitterlinden AG, Uusitupa M, van der Harst P, Vollenweider P, Wallaschofski H, Wareham NJ, Watkins H, Wichmann HE, Wilson JF, Abecasis GR, Assimes TL, Barroso I, Boehnke M, Borecki IB, Deloukas P, Fox CS, Frayling T, Groop LC, Haritunian T, Heid IM, Hunter D, Kaplan RC, Karpe F, Moffatt MF, Mohlke KL, O'Connell JR, Pawitan Y, Schadt EE, Schlessinger D, Steinthorsdottir V, Strachan DP, Thorsteinsdottir U, van Duijn CM, Visscher PM, Di Blasio AM, Hirschhorn JN, Lindgren CM, Morris AP, Meyre D, Scherag A, McCarthy MI, Speliotes EK, North KE, Loos RJ, Ingelsson E. (2013)
    Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
    in Nature genetics (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Berndt SI, Gustafsson S, Mägi R, Ganna A, Wheeler E, Feitosa MF, Justice AE, Monda KL, Croteau-Chonka DC, Day FR, Esko T, Fall T, Ferreira T, Gentilini D, Jackson AU, Luan J, Randall JC, Vedantam S, Willer CJ, Winkler TW, Wood AR, Workalemahu T, Hu YJ, Lee SH, Liang L, Lin DY, Min JL, Neale BM, Thorleifsson G, Yang J, Albrecht E, Amin N, Bragg-Gresham JL, Cadby G, den Heijer M, Eklund N, Fischer K, Goel A, Hottenga JJ, Huffman JE, Jarick I, Johansson Å, Johnson T, Kanoni S, Kleber ME, König IR, Kristiansson K, Kutalik Z, Lamina C, Lecoeur C, Li G, Mangino M, McArdle WL, Medina-Gomez C, Müller-Nurasyid M, Ngwa JS, Nolte IM, Paternoster L, Pechlivanis S, Perola M, Peters MJ, Preuss M, Rose LM, Shi J, Shungin D, Smith AV, Strawbridge RJ, Surakka I, Teumer A, Trip MD, Tyrer J, Van Vliet-Ostaptchouk JV, Vandenput L, Waite LL, Zhao JH, Absher D, Asselbergs FW, Atalay M, Attwood AP, Balmforth AJ, Basart H, Beilby J, Bonnycastle LL, Brambilla P, Bruinenberg M, Campbell H, Chasman DI, Chines PS, Collins FS, Connell JM, Cookson WO, de Faire U, de Vegt F, Dei M, Dimitriou M, Edkins S, Estrada K, Evans DM, Farrall M, Ferrario MM, Ferrières J, Franke L, Frau F, Gejman PV, Grallert H, Grönberg H, Gudnason V, Hall AS, Hall P, Hartikainen AL, Hayward C, Heard-Costa NL, Heath AC, Hebebrand J, Homuth G, Hu FB, Hunt SE, Hyppönen E, Iribarren C, Jacobs KB, Jansson JO, Jula A, Kähönen M, Kathiresan S, Kee F, Khaw KT, Kivimäki M, Koenig W, Kraja AT, Kumari M, Kuulasmaa K, Kuusisto J, Laitinen JH, Lakka TA, Langenberg C, Launer LJ, Lind L, Lindström J, Liu J, Liuzzi A, Lokki ML, Lorentzon M, Madden PA, Magnusson PK, Manunta P, Marek D, März W, Mateo Leach I, McKnight B, Medland SE, Mihailov E, Milani L, Montgomery GW, Mooser V, Mühleisen TW, Munroe PB, Musk AW, Narisu N, Navis G, Nicholson G, Nohr EA, Ong KK, Oostra BA, Palmer CN, Palotie A, Peden JF, Pedersen N, Peters A, Polasek O, Pouta A, Pramstaller PP, Prokopenko I, Pütter C, Radhakrishnan A, Raitakari O, Rendon A, Rivadeneira F, Rudan I, Saaristo TE, Sambrook JG, Sanders AR, Sanna S, Saramies J, Schipf S, Schreiber S, Schunkert H, Shin SY, Signorini S, Sinisalo J, Skrobek B, Soranzo N, Stan?áková A, Stark K, Stephens JC, Stirrups K, Stolk RP, Stumvoll M, Swift AJ, Theodoraki EV, Thorand B, Tregouet DA, Tremoli E, Van der Klauw MM, van Meurs JB, Vermeulen SH, Viikari J, Virtamo J, Vitart V, Waeber G, Wang Z, Widén E, Wild SH, Willemsen G, Winkelmann BR, Witteman JC, Wolffenbuttel BH, Wong A, Wright AF, Zillikens MC, Amouyel P, Boehm BO, Boerwinkle E, Boomsma DI, Caulfield MJ, Chanock SJ, Cupples LA, Cusi D, Dedoussis GV, Erdmann J, Eriksson JG, Franks PW, Froguel P, Gieger C, Gyllensten U, Hamsten A, Harris TB, Hengstenberg C, Hicks AA, Hingorani A, Hinney A, Hofman A, Hovingh KG, Hveem K, Illig T, Jarvelin MR, Jöckel KH, Keinanen-Kiukaanniemi SM, Kiemeney LA, Kuh D, Laakso M, Lehtimäki T, Levinson DF, Martin NG, Metspalu A, Morris AD, Nieminen MS, Njølstad I, Ohlsson C, Oldehinkel AJ, Ouwehand WH, Palmer LJ, Penninx B, Power C, Province MA, Psaty BM, Qi L, Rauramaa R, Ridker PM, Ripatti S, Salomaa V, Samani NJ, Snieder H, Sørensen TI, Spector TD, Stefansson K, Tönjes A, Tuomilehto J, Uitterlinden AG, Uusitupa M, van der Harst P, Vollenweider P, Wallaschofski H, Wareham NJ, Watkins H, Wichmann HE, Wilson JF, Abecasis GR, Assimes TL, Barroso I, Boehnke M, Borecki IB, Deloukas P, Fox CS, Frayling T, Groop LC, Haritunian T, Heid IM, Hunter D, Kaplan RC, Karpe F, Moffatt MF, Mohlke KL, O'Connell JR, Pawitan Y, Schadt EE, Schlessinger D, Steinthorsdottir V, Strachan DP, Thorsteinsdottir U, van Duijn CM, Visscher PM, Di Blasio AM, Hirschhorn JN, Lindgren CM, Morris AP, Meyre D, Scherag A, McCarthy MI, Speliotes EK, North KE, Loos RJ, Ingelsson E. (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • US Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA. Sonja I Berndt, Jianxin Shi, Kevin B Jacobs, Zhaoming Wang & Stephen J Chanock Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden. Stefan Gustafsson & Erik Ingelsson Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. Stefan Gustafsson, Andrea Ganna, Tove Fall, Henrik Grönberg, Per Hall, Patrik K Magnusson, Nancy Pedersen, Yudi Pawitan & Erik Ingelsson Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. Reedik Mägi, Teresa Ferreira, Joshua C Randall, Josine L Min, Inga Prokopenko, Cecilia M Lindgren, Andrew P Morris, Mark I McCarthy & Erik Ingelsson Estonian Genome Center, University of Tartu, Tartu, Estonia. Reedik Mägi, Tõnu Esko, Krista Fischer, Markus Perola, Evelin Mihailov, Lili Milani & Andres Metspalu Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK. Eleanor Wheeler, Joshua C Randall, Stavroula Kanoni, Sarah Edkins, Sarah E Hunt, Aarno Palotie, Aparna Radhakrishnan, So-Youn Shin, Nicole Soranzo, Kathleen Stirrups, Willem H Ouwehand, Samuli Ripatti, Inês Barroso & Panos Deloukas Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, USA. Mary F Feitosa, Aldi T Kraja, Michael A Province & Ingrid B Borecki Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. Anne E Justice, Keri L Monda & Kari E North Center for Observational Research, Amgen, Thousands Oaks, California, USA. Keri L Monda Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. Damien C Croteau-Chonka & Karen L Mohlke Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK. Felix R Day, Jian'an Luan, Jing Hua Zhao, Claudia Langenberg, Ken K Ong, Nicholas J Wareham & Ruth J F Loos Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia. Tõnu Esko, Evelin Mihailov & Andres Metspalu Molecular Biology Department, Istituto Auxologico Italiano, Milan, Italy. Davide Gentilini & Anna Maria Di Blasio Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA. Anne U Jackson, Jennifer L Bragg-Gresham, Goncalo R Abecasis & Michael Boehnke Divisions of Genetics and Endocrinology and Center for Basic and Translational Obesity Research, Children's Hospital, Boston, Massachusetts, USA. Sailaja Vedantam & Joel N Hirschhorn Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA. Sailaja Vedantam, Sekar Kathiresan & Joel N Hirschhorn Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA. Sailaja Vedantam & Joel N Hirschhorn Department of Internal Medicine (Cardiovascular), University of Michigan, Ann Arbor, Michigan, USA. Cristen J Willer Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA. Cristen J Willer Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA. Cristen J Willer & Elizabeth K Speliotes Public Health and Gender Studies, Institute of Epidemiology and Preventive Medicine, Regensburg University Medical Center, Regensburg, Germany. Thomas W Winkler & Iris M Heid Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, UK. Andrew R Wood, Timothy Frayling & Erik Ingelsson Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA. Tsegaselassie Workalemahu, Frank B Hu, Paul W Franks, Lu Qi & David Hunter Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. Tsegaselassie Workalemahu, Lu Qi & David Hunter Department of Biostatistics and Bioinformatics, Emory University, Atlanta, Georgia, USA. Yi-Juan Hu The Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia. Sang Hong Lee & Peter M Visscher Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. Liming Liang Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA. Liming Liang Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. Dan-Yu Lin Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts, USA. Benjamin M Neale deCODE Genetics, Reykjavik, Iceland. Gudmar Thorleifsson, Kari Stefansson, Valgerdur Steinthorsdottir & Unnur Thorsteinsdottir University of Queensland Diamantina Institute, The University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland, Australia. Jian Yang & Peter M Visscher Queensland Institute of Medical Research, Brisbane, Queensland, Australia. Jian Yang, Sarah E Medland, Grant W Montgomery & Nicholas G Martin Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. Eva Albrecht, Martina Müller-Nurasyid & Christian Gieger Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands. Najaf Amin, Carolina Medina-Gomez, Marjolein J Peters, Karol Estrada, Fernando Rivadeneira, Joyce B J van Meurs, Jacqueline C M Witteman, Albert Hofman, André G Uitterlinden & Cornelia M van Duijn Genetic Epidemiology and Biostatistics Platform, Ontario Institute for Cancer Research, Toronto, Ontario, Canada. Gemma Cadby & Lyle J Palmer Prosserman Centre for Health Research, Samuel Lunenfeld Research Institute, Toronto, Ontario, Canada. Gemma Cadby & Lyle J Palmer Centre for Genetic Epidemiology and Biostatistics, The University of Western Australia, Crawley, Western Australia, Australia. Gemma Cadby Department of Internal Medicine, VU University Medical Centre, Amsterdam, The Netherlands. Martin den Heijer Unit of Public Health Genomics, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland. Niina Eklund, Kati Kristiansson, Markus Perola & Ida Surakka Cardiovascular Medicine, University of Oxford, Wellcome Trust Centre for Human Genetics, Oxford, UK. Anuj Goel, Martin Farrall, Samuli Ripatti & Hugh Watkins Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands. Jouke-Jan Hottenga, Gonneke Willemsen & Dorret I Boomsma MRC Human Genetics Unit, MRC Institute for Genetics and Molecular Medicine, Western General Hospital, Edinburgh, UK. Jennifer E Huffman, Caroline Hayward, Veronique Vitart & Alan F Wright Institute of Medical Biometry and Epidemiology, University of Marburg, Marburg, Germany. Ivonne Jarick Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden. Åsa Johansson & Ulf Gyllensten Uppsala Clinical Research Center, Uppsala University Hospital, Uppsala, Sweden. Åsa Johansson Genome Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. Toby Johnson, Patricia B Munroe & Mark J Caulfield Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. Toby Johnson, Patricia B Munroe & Mark J Caulfield Ludwigshafen Risk and Cardiovascular Health (LURIC) Study, Freiburg, Germany. Marcus E Kleber Mannheim Institute of Public Health, Social and Preventive Medicine, Medical Faculty of Mannheim, University of Heidelberg, Mannheim, Germany. Marcus E Kleber & Winfried März Institut für Medizinische Biometrie und Statistik, Universität zu Lübeck, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Lübeck, Germany. Inke R König & Michael Preuss Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland. Zoltán Kutalik & Diana Marek Swiss Institute of Bioinformatics, Lausanne, Switzerland. Zoltán Kutalik & Diana Marek Department of Medical Genetics, Division of Genetic Epidemiology, Molecular and Clinical Pharmacology, Innsbruck Medical University, Innsbruck, Austria. Claudia Lamina University Lille Nord de France, Lille, France. Cecile Lecoeur, Boris Skrobek, Philippe Froguel & David Meyre Centre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche (UMR) 8199, Institut de Biologie de Lille (IBL)-Institut Pasteur de Lille, Lille, France. Cecile Lecoeur, Boris Skrobek, Philippe Froguel & David Meyre Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, USA. Guo Li & Bruce M Psaty Department of Twin Research and Genetic Epidemiology, King's College London, London, UK. Massimo Mangino, Nicole Soranzo & Timothy D Spector School of Social and Community Medicine, University of Bristol, Bristol, UK. Wendy L McArdle Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands. Carolina Medina-Gomez, Marjolein J Peters, Karol Estrada, Fernando Rivadeneira, Joyce B J van Meurs, M Carola Zillikens & André G Uitterlinden Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), The Netherlands. Carolina Medina-Gomez, Marjolein J Peters, Karol Estrada, Ben A Oostra, Fernando Rivadeneira, Joyce B J van Meurs, Jacqueline C M Witteman, M Carola Zillikens, Albert Hofman, André G Uitterlinden & Cornelia M van Duijn Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich, Germany. Martina Müller-Nurasyid Chair of Epidemiology, Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany. Martina Müller-Nurasyid & H-Erich Wichmann Chair of Genetic Epidemiology, Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany. Martina Müller-Nurasyid Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA. Julius S Ngwa & L Adrienne Cupples Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Ilja M Nolte, Ronald P Stolk & Harold Snieder MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, UK. Lavinia Paternoster & David M Evans Institute for Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital of Essen, University of Duisburg-Essen, Essen, Germany. Sonali Pechlivanis, Carolin Pütter, Karl-Heinz Jöckel & André Scherag Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland. Markus Perola, Ida Surakka, Aarno Palotie, Elisabeth Widén & Samuli Ripatti Medizinische Klinik II, Universität zu Lübeck, Lübeck, Germany. Michael Preuss & Jeanette Erdmann Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA. Lynda M Rose, Daniel I Chasman & Paul M Ridker Genetic and Molecular Epidemiology Unit, Department of Clinical Sciences, SkÃ¥ne University Hospital Malmö, Lund University, Malmö, Sweden. Dmitry Shungin & Paul W Franks Department of Public Health & Clinical Medicine, UmeÃ¥ University, UmeÃ¥, Sweden. Dmitry Shungin & Paul W Franks Department of Odontology, UmeÃ¥ University, UmeÃ¥, Sweden. Dmitry Shungin Icelandic Heart Association, Kopavogur, Iceland. Albert Vernon Smith & Vilmundur Gudnason Faculty of Medicine, University of Iceland, Reykjavik, Iceland. Albert Vernon Smith, Vilmundur Gudnason, Kari Stefansson & Unnur Thorsteinsdottir Atherosclerosis Research Unit, Department of Medicine, Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden. Rona J Strawbridge & Anders Hamsten Interfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany. Alexander Teumer & Georg Homuth Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands. Mieke D Trip, Hanneke Basart & Kees G Hovingh Heart Failure Research Centre, Department of Clinical and Experimental Cardiology, Academic Medical Center, Amsterdam, The Netherlands. Mieke D Trip Department of Oncology, University of Cambridge, Cambridge, UK. Jonathan Tyrer Department of Endocrinology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. Jana V Van Vliet-Ostaptchouk, Melanie M Van der Klauw & Bruce H R Wolffenbuttel LifeLines Cohort Study, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. Jana V Van Vliet-Ostaptchouk, Marcel Bruinenberg, Lude Franke, Ronald P Stolk, Melanie M Van der Klauw, Bruce H R Wolffenbuttel & Harold Snieder Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. Liesbeth Vandenput & Mattias Lorentzon Hudson Alpha Institute for Biotechnology, Huntsville, Alabama, USA. Lindsay L Waite, Devin Absher & Claes Ohlsson Department of Cardiology, Division of Heart & Lungs, University Medical Center Utrecht, Utrecht, The Netherlands. Folkert W Asselbergs Institute of Biomedicine/Physiology, University of Eastern Finland, Kuopio Campus, Kuopio, Finland. Mustafa Atalay & Timo A Lakka National Institute for Health Research (NIHR) Cambridge Biomedical Research Centre, Cambridge, UK. Antony P Attwood, Augusto Rendon & Willem H Ouwehand Division of Epidemiology, Multidisciplinary Cardiovascular Research Centre (MCRC), Leeds Institute of Genetics, Health and Therapeutics (LIGHT), University of Leeds, Leeds, UK. Anthony J Balmforth Department of Molecular Genetics, PathWest Laboratory of Western Australia, Queen Elizabeth II Medical Centre, Nedlands, Western Australia, Australia. John Beilby Department of Surgery and Pathology, University of Western Australia, Nedlands, Western Australia, Australia. John Beilby Genome Technology Branch, National Human Genome Research Institute, US National Institutes of Health, Bethesda, Maryland, USA. Lori L Bonnycastle, Peter S Chines, Francis S Collins, Narisu Narisu & Amy J Swift Dipartimento di Medicina Sperimentale. Università degli Studi Milano-Bicocca, Monza, Italy. Paolo Brambilla Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK. Harry Campbell, Igor Rudan, Sarah H Wild & James F Wilson Harvard Medical School, Boston, Massachusetts, USA. Daniel I Chasman & Paul M Ridker British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK. John M Connell University of Dundee, Ninewells Hospital & Medical School, Dundee, UK. John M Connell National Heart and Lung Institute, Imperial College London, London, UK. William O Cookson & Miriam F Moffatt Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. Ulf de Faire Department of Epidemiology, Biostatistics and HTA, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. Femmie de Vegt, Sita H Vermeulen & Lambertus A Kiemeney Istituto di Ricerca Genetica e Biomedica del Consiglio Nazionale delle Ricerche (CNR), Monserrato, Italy. Mariano Dei & Serena Sanna Department of Dietetics-Nutrition, Harokopio University, Athens, Greece. Maria Dimitriou, Eirini V Theodoraki & George V Dedoussis Epidemiology and Preventive Medicine Research Center, Department of Clinical and Experimental Medicine, University of Insubria, Varese, Italy. Marco M Ferrario Department of Cardiology, Toulouse University School of Medicine, Rangueil Hospital, Toulouse, France. Jean Ferrières Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. Lude Franke & Pim van der Harst Department of Health Sciences, University of Milan, Ospedale San Paolo, Milan, Italy. Francesca Frau & Daniele Cusi University of Chicago, Chicago, Illinois, USA. Pablo V Gejman & Alan R Sanders Northshore University Health System, Evanston, Illinois, USA. Pablo V Gejman & Alan R Sanders Research Unit for Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. Harald Grallert, Annette Peters & Thomas Illig Division of Cardiovascular and Neuronal Remodelling, Multidisciplinary Cardiovascular Research Centre, LIGHT, University of Leeds, Leeds, UK. Alistair S Hall Department of Clinical Sciences/Obstetrics and Gynecology, University of Oulu, Oulu, Finland. Anna-Liisa Hartikainen & Anneli Pouta Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA. Nancy L Heard-Costa Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA. Andrew C Heath & Pamela A Madden Department of Child and Adolescent Psychiatry, University of Duisburg-Essen, Essen, Germany. Johannes Hebebrand & Anke Hinney Centre For Paediatric Epidemiology and Biostatistics, MRC Centre of Epidemiology for Child Health, University College London Institute of Child Health, London, UK. Elina Hyppönen & Chris Power Division of Research, Kaiser Permanente Northern California, Oakland, California, USA. Carlos Iribarren Core Genotyping Facility, SAIC-Frederick, Inc., National Cancer Institute (NCI)-Frederick, Frederick, Maryland, USA. Kevin B Jacobs & Zhaoming Wang Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. John-Olov Jansson Population Studies Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Turku, Finland. Antti Jula Department of Clinical Physiology, University of Tampere and Tampere University Hospital, Tampere, Finland. Mika Kähönen Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA. Sekar Kathiresan Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts, USA. Sekar Kathiresan Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA. Sekar Kathiresan UK Clinical Research Collaboration (UKCRC) Centre of Excellence for Public Health (Northern Ireland), Queens University, Belfast, UK. Frank Kee Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK. Kay-Tee Khaw Department of Epidemiology and Public Health, University College London, London, UK. Mika Kivimäki, Meena Kumari, Claudia Langenberg & Aroon Hingorani Department of Internal Medicine II-Cardiology, University of Ulm Medical Center, Ulm, Germany. Wolfgang Koenig Chronic Disease Epidemiology and Prevention Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland. Kari Kuulasmaa, Jarmo Virtamo & Veikko Salomaa Department of Medicine, University of Eastern Finland, Kuopio Campus and Kuopio University Hospital, Kuopio, Finland. Johanna Kuusisto & Markku Laakso Finnish Institute of Occupational Health, Oulu, Finland. Jaana H Laitinen Kuopio Research Institute of Exercise Medicine, Kuopio, Finland. Timo A Lakka & Rainer Rauramaa Laboratory of Epidemiology, Demography, Biometry, National Institute on Aging, US National Institutes of Health, Bethesda, Maryland, USA. Lenore J Launer & Tamara B Harris Department of Medical Sciences, Uppsala University, Akademiska Sjukhuset, Uppsala, Sweden. Lars Lind Diabetes Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland. Jaana Lindström & Jaakko Tuomilehto Human Genetics, Genome Institute of Singapore, Singapore. Jianjun Liu Department of Internal Medicine, Istituto Auxologico Italiano, Verbania, Italy. Antonio Liuzzi Transplantation Laboratory, Haartman Institute, University of Helsinki, Helsinki, Finland. Marja-Liisa Lokki Chair of Nephrology San Raffaele Scientific Institute, Università Vita-Salute San Raffaele, Unit Ospedaliera Nephrology and Dialysis, Milan, Italy. Paolo Manunta Synlab Academy, Mannheim, Germany. Winfried März Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. Irene Mateo Leach & Pim van der Harst Department of Biostatistics, University of Washington, Seattle, Washington, USA. Barbara McKnight Genetics Division, GlaxoSmithKline, King of Prussia, Pennsylvania, USA. Vincent Mooser Institute of Human Genetics, University of Bonn, Bonn, Germany. Thomas W Mühleisen Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany. Thomas W Mühleisen School of Population Health, The University of Western Australia, Nedlands, Western Australia, Australia. Arthur W Musk Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia. Arthur W Musk Busselton Population Medical Research Foundation, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia. Arthur W Musk Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. Gerjan Navis MRC Harwell, Harwell, UK. George Nicholson Department of Statistics, University of Oxford, Oxford, UK. George Nicholson Section of Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark. Ellen A Nohr MRC Unit for Lifelong Health & Ageing, London, UK. Ken K Ong, Andrew Wong & Diana Kuh Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands. Ben A Oostra Center of Medical Systems Biology, Leiden University Medical Center, Leiden, The Netherlands. Ben A Oostra & Cornelia M van Duijn Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK. Colin N A Palmer & Andrew D Morris Illumina, Inc., Cambridge, UK. John F Peden Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. Annette Peters & Barbara Thorand Munich Heart Alliance, Munich, Germany. Annette Peters Faculty of Medicine, University of Split, Split, Croatia. Ozren Polasek National Institute for Health and Welfare, Oulu, Finland. Anneli Pouta & Marjo-Riitta Jarvelin Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano/Bozen, Italy (affiliated institute of the University of Lübeck). Peter P Pramstaller & Andrew A Hicks Department of Neurology, General Central Hospital, Bolzano, Italy. Peter P Pramstaller Department of Neurology, University of Lübeck, Lübeck, Germany. Peter P Pramstaller Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK. Inga Prokopenko, Fredrik Karpe & Mark I McCarthy Department of Haematology, University of Cambridge, Cambridge, UK. Aparna Radhakrishnan, Augusto Rendon, Jennifer G Sambrook, Jonathan C Stephens & Willem H Ouwehand National Health Service (NHS) Blood and Transplant, Cambridge Centre, Cambridge, UK. Aparna Radhakrishnan, Augusto Rendon, Jennifer G Sambrook, Jonathan C Stephens & Willem H Ouwehand Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland. Olli Raitakari The Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland. Olli Raitakari MRC Biostatistics Unit, Institute of Public Health, Cambridge, UK. Augusto Rendon Finnish Diabetes Association, Tampere, Finland. Timo E Saaristo Pirkanmaa Hospital District, Tampere, Finland. Timo E Saaristo South Karelia Central Hospital, Lappeenranta, Finland. Jouko Saramies Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany. Sabine Schipf Institute for Clinical Molecular Biology, Christian-Albrechts University, Kiel, Germany. Stefan Schreiber Deutsches Herzzentrum München and DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany. Heribert Schunkert & Jeanette Erdmann Azienda Ospedaliera di Desio e Vimercate, Milan, Italy. Stefano Signorini Division of Cardiology, Cardiovascular Laboratory, Helsinki University Central Hospital, Helsinki, Finland. Juha Sinisalo & Markku S Nieminen University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland. Alena Stan?áková Klinik und Poliklinik für Innere Medizin II, Universitätklinikum Regensburg, Regensburg, Germany. Klaus Stark & Christian Hengstenberg Department of Medicine, University of Leipzig, Leipzig, Germany. Michael Stumvoll & Anke Tönjes Integrierte Forschungs- und Behandlungszentren (IFB) Adiposity Diseases, University of Leipzig, Leipzig, Germany. Michael Stumvoll & Anke Tönjes Institut National de la Santé et de la Recherche Médicale (INSERM) Unité Mixte de Recherche Scientifique (UMRS) 937, Institute of Cardiometabolism And Nutrition (ICAN), Pierre et Marie Curie Medical School, Paris, France. David-Alexandre Tregouet Dipartimento di Scienze Farmacologiche e Biomolecolari, Università di Milano, Centro Cardiologico Monzino, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Milan, Italy. Elena Tremoli Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. Sita H Ve?????????????????À????????2Øaffiliazioni????@University of Mahidol University of Mahidol IASI-CNR IASI-CNR??2Úaffiliazioni????[Università Campus BioMedico di Roma IASI-CNR Università degli Studi dell'Aquila IASI-CNR??2Ûaffiliazioni????VIASI-CNR Università di Roma \"La Sapienza\" Università di Roma \"La Sapienza\" IASI-CNR??2Üaffiliazioni????@IASI-CNR Università degli Studi dell'Aquila IASI-CNR IASI-CNR??2Ýaffiliazioni?????CNR-IASI BioMatLab, UCSC Largo A., Gemelli 8, 00168, Rome, Italy; Department of Surgery, Transplantation Service Catholic University, A. Gemelli Hospital, Rome, Italy; Institute of General Pathology, Catholic University, Largo F. Vito 1, 00168, Rome, Italy??2Þaffiliazioni????öIstituto di Analisi dei Sistemi ed Informatica A. Ruberti, Consiglio Nazionale Delle Ricerche, BioMatLab, UCSC, Largo A. Gemelli 8, 00168 Roma, Italy; Dipartimento di Ingegneria Elettrica e dell'Informazione, 67040 Poggio di Roio, L'Aquila, Italy??2ßaffiliazioni????bUniversity of Luoisville, KY, USA University of Luoisville, KY, USA IASI-CNR IASI-CNR IASI-CNR??2àaffiliazioni????@IASI-CNR Università degli Studi dell'Aquila IASI-CNR IASI-CNR??2áaffiliazioni????QUniversità Campus BioMedico di Roma Università degli Studi dell'Aquila IASI-CNR??2âaffiliazioni????PUniversità degli Studi dell'Aquila Università degli Studi dell'Aquila IASI-CNR??2æaffiliazioni???? CNR ISPAAM??2çaffiliazioni???(SEleonora Porcu, Maria G. Piras, Gianluca Usala, Francesco Cucca, Serena Sanna, Silvia Naitza Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy Eleonora Porcu, Francesco Cucca Dipartimento di Scienze Biomediche, Università di Sassari, Sassari, Italy Marco Medici, Fernando Rivadeneira, Alies van Mullem, W. Edward Visser, André G. Uitterlinden, Theo J. Visser, Robin P. Peeters Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands Giorgio Pistis, Clara Camaschella, Corrado Masciullo, Cinzia Sala, Daniela Toniolo Division of Genetics and Cell Biology, San Raffaele Research Institute, Milano, Italy Giorgio Pistis Università degli Studi di Trieste, Trieste, Italy Claudia B. Volpato, Martin Gögele, Cosetta Minelli, Peter P. Pramstaller, Andrew A. Hicks Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy (Affiliated Institute of the University of Lübeck, Lübeck, Germany) Scott G. Wilson, Suzanne J. Brown, Ee M. Lim, John P. Walsh Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia Scott G. Wilson, J. Brent Richards, Guangju Zhai, Tim D. Spector Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom Scott G. Wilson, John P. Walsh School of Medicine and Pharmacology, University of Western Australia, Crawley, Western Australia, Australia Anne R. Cappola University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America Steffan D. Bos, Joris Deelen, Marian Beekman, Eline P. Slagboom, Ingrid Meulenbelt Leiden University Medical Center, Molecular Epidemiology, Leiden, The Netherlands Steffan D. Bos, Joris Deelen, Marian Beekman, Eline P. Slagboom, Ingrid Meulenbelt Netherlands Consortium for Healthy Ageing, Leiden, The Netherlands Martin den Heijer, Ad R. Hermus, Romana T. Netea-Maier Department of Endocrinology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands Martin den Heijer Department of Internal Medicine, Free University Medical Center, Amsterdam, The Netherlands Rachel M. Freathy, Timothy M. Frayling Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, United Kingdom Jari Lahti, Katri Räikkönen Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland Chunyu Liu Center for Population Studies, National Heart, Lung, and Blood Institute, Framingham, Massachusetts, United States of America Lorna M. Lopez, John M. Starr, Ian J. Deary Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom Lorna M. Lopez, Gail Davies, Ian J. Deary Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom Ilja M. Nolte Unit of Genetic Epidemiology and Bioinformatics, Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands Jeffrey R. O'Connell, Braxton D. Mitchell, Alan R. Shuldiner Department of Medicine, University of Maryland Medical School, Baltimore, Maryland, United States of America Toshiko Tanaka, Luigi Ferrucci Clinical Research Branch, National Institute on Aging, Baltimore, Maryland, United States of America Stella Trompet, J. Wouter Jukema Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands Stella Trompet, Anton J. M. de Craen Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands Alice Arnold, Richard A. Jensen Cardiovascular Health Research Unit and Department of Medicine, University of Washington, Seattle, Washington, United States of America Stefania Bandinelli Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy Stefan Böhringer, Jeanine J. Houwing-Duistermaat Leiden University Medical Center, Medical Statistics and Bioinformatics, Leiden, The Netherlands Brendan M. Buckley Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland Clara Camaschella Vita e Salute University, San Raffaele Scientific Institute, Milano, Italy Marieke C. H. de Visser, Sita H.Vermeulen, Lambertus A. Kiemeney Department for Health Evidence, Radboud University Medical Centre, Nijmegen, The Netherlands Ian Ford Robertson Center for Biostatistics, University of Glasgow, Glasgow, United Kingdom Tom Forsen, Eero Kajantie, Johan G. Eriksson Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland Tom Forsen, Johan G. Eriksson Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland Tom Forsen, Johan G. Eriksson Helsinki University Central Hospital, Unit of General Practice, Helsinki, Finland Tom Forsen Vaasa Health Care Centre, Diabetes Unit, Vaasa, Finland Laura Fugazzola Endocrine Unit, Fondazione Ca' Granda Policlinico and Department of Clinical Sciences and Community Health, University of Milan, Milano, Italy Andrew T. Hattersley, Beverley M. Shields Peninsula NIHR Clinical Research Facility, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, United Kingdom Albert Hofman, Fernando Rivadeneira, André G. Uitterlinden Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands Albert Hofman, Fernando Rivadeneira, André G. Uitterlinden Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, The Netherlands Eero Kajantie Hospital for Children and Adolescents, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland Margreet Kloppenburg Department of Clinical Epidemiology and Rheumatology, Leiden University Medical Center, Leiden, The Netherlands Ee M. Lim Pathwest Laboratory Medicine WA, Nedlands, Western Australia, Australia Stefano Mariotti Dipartimento di Scienze Mediche, Università di Cagliari, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy Ramaiah Nagaraja, David Schlessinger Laboratory of Genetics, National Institute on Aging, Baltimore, Maryland, United States of America Aarno Palotie, Nicole Soranzo Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, United Kingdom Aarno Palotie, Elisabeth Widen Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland Aarno Palotie Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki, Finland Luca Persani Department of Clinical Sciences and Community Health, University of Milan, Milano, Italy Luca Persani Division of Endocrinology and Metabolic Diseases, IRCCS Ospedale San Luca, Milan, Italy Bruce M. Psaty Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Services, University of Washington, Seattle, Washington, United States of America Bruce M. Psaty Group Health Research Institute, Group Health Cooperative, Seattle, Washington, United States of America J. Brent Richards Department of Medicine, Jewish General Hospital, McGill University, Montréal, Québec, Canada J. Brent Richards Departments of Human Genetics, Epidemiology, and Biostatistics, Jewish General Hospital, Lady Davis Institute, McGill University, Montréal, Québec Mona M. Sabra Memorial Sloan Kettering Cancer Center, Medicine-Endocrinology, New York, New York, United States of America Naveed Sattar BHF Glasgow Cardiovascular Research Centre, Faculty of Medicine, Glasgow, United Kingdom John M. Starr Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, United Kingdom David J. Stott Academic Section of Geriatric Medicine, Faculty of Medicine, University of Glasgow, Glasgow, United Kingdom Fred C. G. J. Sweep Department of Laboratory Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands Melanie M. van der Klauw, Bruce H. R. Wolffenbuttel LifeLines Cohort Study, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands Melanie M. van der Klauw, Bruce H. R. Wolffenbuttel Department of Endocrinology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands Diana van Heemst, Rudi G. J. Westendorp Leiden University Medical Center, Gerontology and Geriatrics, Leiden, The Netherlands Guangju Zhai Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. Johns, Newfoundland, Canada Johan G. Eriksson Folkhalsan Research Centre, Helsinki, Finland Johan G. Eriksson Vasa Central Hospital, Vasa, Finland Caroline S. Fox Division of Intramural Research, National Heart, Lung, and Blood Institute, Framingham, Massachusetts, United States of America Caroline S. Fox Division of Endocrinology, Hypertension, and Metabolism, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America J. Wouter Jukema Durrer Center for Cardiogenetic Research, Amsterdam, The Netherlands J. Wouter Jukema Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands Lambertus A. Kiemeney Department of Urology, Radboud University Medical Centre, Nijmegen, The Netherlands Peter P. Pramstaller Department of Neurology, General Central Hospital, Bolzano, Italy Peter P. Pramstaller Department of Neurology, University of Lübeck, Lübeck, Germany Alan R. Shuldiner Geriatric Research and Education Clinical Center, Veterans Administration Medical Center, Baltimore, Maryland, United States of America Bijay Vaidya Diabetes, Endocrinology and Vascular Health Centre, Royal Devon and Exeter NHS Foundation Trust, Exeter, United Kingdom Jerome I. Rotter Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America Daniela Toniolo Institute of Molecular Genetics-CNR, Pavia, Italy??2èaffiliazioni???? CNR ISPAAM??2éaffiliazioni???túUS Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA. Sonja I Berndt, Jianxin Shi, Kevin B Jacobs, Zhaoming Wang & Stephen J Chanock Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden. Stefan Gustafsson & Erik Ingelsson Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. Stefan Gustafsson, Andrea Ganna, Tove Fall, Henrik Grönberg, Per Hall, Patrik K Magnusson, Nancy Pedersen, Yudi Pawitan & Erik Ingelsson Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. Reedik Mägi, Teresa Ferreira, Joshua C Randall, Josine L Min, Inga Prokopenko, Cecilia M Lindgren, Andrew P Morris, Mark I McCarthy & Erik Ingelsson Estonian Genome Center, University of Tartu, Tartu, Estonia. Reedik Mägi, Tõnu Esko, Krista Fischer, Markus Perola, Evelin Mihailov, Lili Milani & Andres Metspalu Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK. Eleanor Wheeler, Joshua C Randall, Stavroula Kanoni, Sarah Edkins, Sarah E Hunt, Aarno Palotie, Aparna Radhakrishnan, So-Youn Shin, Nicole Soranzo, Kathleen Stirrups, Willem H Ouwehand, Samuli Ripatti, Inês Barroso & Panos Deloukas Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, USA. Mary F Feitosa, Aldi T Kraja, Michael A Province & Ingrid B Borecki Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. Anne E Justice, Keri L Monda & Kari E North Center for Observational Research, Amgen, Thousands Oaks, California, USA. Keri L Monda Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. Damien C Croteau-Chonka & Karen L Mohlke Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK. Felix R Day, Jian'an Luan, Jing Hua Zhao, Claudia Langenberg, Ken K Ong, Nicholas J Wareham & Ruth J F Loos Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia. Tõnu Esko, Evelin Mihailov & Andres Metspalu Molecular Biology Department, Istituto Auxologico Italiano, Milan, Italy. Davide Gentilini & Anna Maria Di Blasio Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA. Anne U Jackson, Jennifer L Bragg-Gresham, Goncalo R Abecasis & Michael Boehnke Divisions of Genetics and Endocrinology and Center for Basic and Translational Obesity Research, Children's Hospital, Boston, Massachusetts, USA. Sailaja Vedantam & Joel N Hirschhorn Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA. Sailaja Vedantam, Sekar Kathiresan & Joel N Hirschhorn Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA. Sailaja Vedantam & Joel N Hirschhorn Department of Internal Medicine (Cardiovascular), University of Michigan, Ann Arbor, Michigan, USA. Cristen J Willer Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA. Cristen J Willer Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA. Cristen J Willer & Elizabeth K Speliotes Public Health and Gender Studies, Institute of Epidemiology and Preventive Medicine, Regensburg University Medical Center, Regensburg, Germany. Thomas W Winkler & Iris M Heid Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, UK. Andrew R Wood, Timothy Frayling & Erik Ingelsson Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA. Tsegaselassie Workalemahu, Frank B Hu, Paul W Franks, Lu Qi & David Hunter Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. Tsegaselassie Workalemahu, Lu Qi & David Hunter Department of Biostatistics and Bioinformatics, Emory University, Atlanta, Georgia, USA. Yi-Juan Hu The Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia. Sang Hong Lee & Peter M Visscher Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. Liming Liang Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA. Liming Liang Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. Dan-Yu Lin Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts, USA. Benjamin M Neale deCODE Genetics, Reykjavik, Iceland. Gudmar Thorleifsson, Kari Stefansson, Valgerdur Steinthorsdottir & Unnur Thorsteinsdottir University of Queensland Diamantina Institute, The University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland, Australia. Jian Yang & Peter M Visscher Queensland Institute of Medical Research, Brisbane, Queensland, Australia. Jian Yang, Sarah E Medland, Grant W Montgomery & Nicholas G Martin Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. Eva Albrecht, Martina Müller-Nurasyid & Christian Gieger Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands. Najaf Amin, Carolina Medina-Gomez, Marjolein J Peters, Karol Estrada, Fernando Rivadeneira, Joyce B J van Meurs, Jacqueline C M Witteman, Albert Hofman, André G Uitterlinden & Cornelia M van Duijn Genetic Epidemiology and Biostatistics Platform, Ontario Institute for Cancer Research, Toronto, Ontario, Canada. Gemma Cadby & Lyle J Palmer Prosserman Centre for Health Research, Samuel Lunenfeld Research Institute, Toronto, Ontario, Canada. Gemma Cadby & Lyle J Palmer Centre for Genetic Epidemiology and Biostatistics, The University of Western Australia, Crawley, Western Australia, Australia. Gemma Cadby Department of Internal Medicine, VU University Medical Centre, Amsterdam, The Netherlands. Martin den Heijer Unit of Public Health Genomics, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland. Niina Eklund, Kati Kristiansson, Markus Perola & Ida Surakka Cardiovascular Medicine, University of Oxford, Wellcome Trust Centre for Human Genetics, Oxford, UK. Anuj Goel, Martin Farrall, Samuli Ripatti & Hugh Watkins Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands. Jouke-Jan Hottenga, Gonneke Willemsen & Dorret I Boomsma MRC Human Genetics Unit, MRC Institute for Genetics and Molecular Medicine, Western General Hospital, Edinburgh, UK. Jennifer E Huffman, Caroline Hayward, Veronique Vitart & Alan F Wright Institute of Medical Biometry and Epidemiology, University of Marburg, Marburg, Germany. Ivonne Jarick Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden. Åsa Johansson & Ulf Gyllensten Uppsala Clinical Research Center, Uppsala University Hospital, Uppsala, Sweden. Åsa Johansson Genome Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. Toby Johnson, Patricia B Munroe & Mark J Caulfield Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. Toby Johnson, Patricia B Munroe & Mark J Caulfield Ludwigshafen Risk and Cardiovascular Health (LURIC) Study, Freiburg, Germany. Marcus E Kleber Mannheim Institute of Public Health, Social and Preventive Medicine, Medical Faculty of Mannheim, University of Heidelberg, Mannheim, Germany. Marcus E Kleber & Winfried März Institut für Medizinische Biometrie und Statistik, Universität zu Lübeck, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Lübeck, Germany. Inke R König & Michael Preuss Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland. Zoltán Kutalik & Diana Marek Swiss Institute of Bioinformatics, Lausanne, Switzerland. Zoltán Kutalik & Diana Marek Department of Medical Genetics, Division of Genetic Epidemiology, Molecular and Clinical Pharmacology, Innsbruck Medical University, Innsbruck, Austria. Claudia Lamina University Lille Nord de France, Lille, France. Cecile Lecoeur, Boris Skrobek, Philippe Froguel & David Meyre Centre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche (UMR) 8199, Institut de Biologie de Lille (IBL)-Institut Pasteur de Lille, Lille, France. Cecile Lecoeur, Boris Skrobek, Philippe Froguel & David Meyre Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, USA. Guo Li & Bruce M Psaty Department of Twin Research and Genetic Epidemiology, King's College London, London, UK. Massimo Mangino, Nicole Soranzo & Timothy D Spector School of Social and Community Medicine, University of Bristol, Bristol, UK. Wendy L McArdle Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands. Carolina Medina-Gomez, Marjolein J Peters, Karol Estrada, Fernando Rivadeneira, Joyce B J van Meurs, M Carola Zillikens & André G Uitterlinden Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), The Netherlands. Carolina Medina-Gomez, Marjolein J Peters, Karol Estrada, Ben A Oostra, Fernando Rivadeneira, Joyce B J van Meurs, Jacqueline C M Witteman, M Carola Zillikens, Albert Hofman, André G Uitterlinden & Cornelia M van Duijn Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich, Germany. Martina Müller-Nurasyid Chair of Epidemiology, Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany. Martina Müller-Nurasyid & H-Erich Wichmann Chair of Genetic Epidemiology, Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany. Martina Müller-Nurasyid Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA. Julius S Ngwa & L Adrienne Cupples Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Ilja M Nolte, Ronald P Stolk & Harold Snieder MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, UK. Lavinia Paternoster & David M Evans Institute for Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital of Essen, University of Duisburg-Essen, Essen, Germany. Sonali Pechlivanis, Carolin Pütter, Karl-Heinz Jöckel & André Scherag Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland. Markus Perola, Ida Surakka, Aarno Palotie, Elisabeth Widén & Samuli Ripatti Medizinische Klinik II, Universität zu Lübeck, Lübeck, Germany. Michael Preuss & Jeanette Erdmann Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA. Lynda M Rose, Daniel I Chasman & Paul M Ridker Genetic and Molecular Epidemiology Unit, Department of Clinical Sciences, Skåne University Hospital Malmö, Lund University, Malmö, Sweden. Dmitry Shungin & Paul W Franks Department of Public Health & Clinical Medicine, Umeå University, Umeå, Sweden. Dmitry Shungin & Paul W Franks Department of Odontology, Umeå University, Umeå, Sweden. Dmitry Shungin Icelandic Heart Association, Kopavogur, Iceland. Albert Vernon Smith & Vilmundur Gudnason Faculty of Medicine, University of Iceland, Reykjavik, Iceland. Albert Vernon Smith, Vilmundur Gudnason, Kari Stefansson & Unnur Thorsteinsdottir Atherosclerosis Research Unit, Department of Medicine, Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden. Rona J Strawbridge & Anders Hamsten Interfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany. Alexander Teumer & Georg Homuth Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands. Mieke D Trip, Hanneke Basart & Kees G Hovingh Heart Failure Research Centre, Department of Clinical and Experimental Cardiology, Academic Medical Center, Amsterdam, The Netherlands. Mieke D Trip Department of Oncology, University of Cambridge, Cambridge, UK. Jonathan Tyrer Department of Endocrinology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. Jana V Van Vliet-Ostaptchouk, Melanie M Van der Klauw & Bruce H R Wolffenbuttel LifeLines Cohort Study, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. Jana V Van Vliet-Ostaptchouk, Marcel Bruinenberg, Lude Franke, Ronald P Stolk, Melanie M Van der Klauw, Bruce H R Wolffenbuttel & Harold Snieder Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. Liesbeth Vandenput & Mattias Lorentzon Hudson Alpha Institute for Biotechnology, Huntsville, Alabama, USA. Lindsay L Waite, Devin Absher & Claes Ohlsson Department of Cardiology, Division of Heart & Lungs, University Medical Center Utrecht, Utrecht, The Netherlands. Folkert W Asselbergs Institute of Biomedicine/Physiology, University of Eastern Finland, Kuopio Campus, Kuopio, Finland. Mustafa Atalay & Timo A Lakka National Institute for Health Research (NIHR) Cambridge Biomedical Research Centre, Cambridge, UK. Antony P Attwood, Augusto Rendon & Willem H Ouwehand Division of Epidemiology, Multidisciplinary Cardiovascular Research Centre (MCRC), Leeds Institute of Genetics, Health and Therapeutics (LIGHT), University of Leeds, Leeds, UK. Anthony J Balmforth Department of Molecular Genetics, PathWest Laboratory of Western Australia, Queen Elizabeth II Medical Centre, Nedlands, Western Australia, Australia. John Beilby Department of Surgery and Pathology, University of Western Australia, Nedlands, Western Australia, Australia. John Beilby Genome Technology Branch, National Human Genome Research Institute, US National Institutes of Health, Bethesda, Maryland, USA. Lori L Bonnycastle, Peter S Chines, Francis S Collins, Narisu Narisu & Amy J Swift Dipartimento di Medicina Sperimentale. Università degli Studi Milano-Bicocca, Monza, Italy. Paolo Brambilla Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK. Harry Campbell, Igor Rudan, Sarah H Wild & James F Wilson Harvard Medical School, Boston, Massachusetts, USA. Daniel I Chasman & Paul M Ridker British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK. John M Connell University of Dundee, Ninewells Hospital & Medical School, Dundee, UK. John M Connell National Heart and Lung Institute, Imperial College London, London, UK. William O Cookson & Miriam F Moffatt Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. Ulf d (literal)
Titolo
  • Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. (literal)
Abstract
  • Approaches exploiting trait distribution extremes may be used to identify loci associated with common traits, but it is unknown whether these loci are generalizable to the broader population. In a genome-wide search for loci associated with the upper versus the lower 5th percentiles of body mass index, height and waist-to-hip ratio, as well as clinical classes of obesity, including up to 263,407 individuals of European ancestry, we identified 4 new loci (IGFBP4, H6PD, RSRC1 and PPP2R2A) influencing height detected in the distribution tails and 7 new loci (HNF4G, RPTOR, GNAT2, MRPS33P4, ADCY9, HS6ST3 and ZZZ3) for clinical classes of obesity. Further, we find a large overlap in genetic structure and the distribution of variants between traits based on extremes and the general population and little etiological heterogeneity between obesity subgroups. (literal)
Prodotto di
Autore CNR

Incoming links:


Prodotto
Autore CNR di
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi
data.CNR.it