Proteome analysis of X-ray irradiated human erythroleukemia cells. (Articolo in rivista)

Type
Label
  • Proteome analysis of X-ray irradiated human erythroleukemia cells. (Articolo in rivista) (literal)
Anno
  • 2008-01-01T00:00:00+01:00 (literal)
Alternative label
  • Eleuterio E, Di Giuseppe F, Sulpizio M, di Giacomo V, Rapino M, Cataldi A, Di Ilio C, Angelucci S. (2008)
    Proteome analysis of X-ray irradiated human erythroleukemia cells.
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Eleuterio E, Di Giuseppe F, Sulpizio M, di Giacomo V, Rapino M, Cataldi A, Di Ilio C, Angelucci S. (literal)
Pagina inizio
  • 611 (literal)
Pagina fine
  • 620 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 1784 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Department of Biomedical Science, G. d'Annunzio University, Chieti-Pescara, Italy; Center of Excellence on Aging, G. d'Annunzio University Foundation, Chieti, Italy; Department of Biomorphology, G. d'Annunzio University, Chieti-Pescara, Italy Institute of Molecular Genetic, CNR, Chieti, Italy. (literal)
Titolo
  • Proteome analysis of X-ray irradiated human erythroleukemia cells. (literal)
Abstract
  • In order to discover molecular biomarkers in radiation response we investigated the effects of X-radiation on radioresistant K562 cells by using a comparative proteomic analysis. In treated cells 29 up-regulated and 10 down-regulated proteins were detected by image analysis and identified by mass spectrometry. Elongation factor 1 alpha 1 and stress-70 protein showed a 6.2 and 5.4 fold increase respectively in treated cells. Additional proteins such us pi and omega classes glutathione transferases, ATP synthase D chain, were also found to be up-regulated, suggesting that the enzyme belonging to the cellular detoxification system against oxidative stress and energetic metabolism may have a key role in the cellular response to radiation injury. This data set may provide a useful tool to design a combined chemo- and radiotherapic strategy against leukemia disease. (literal)
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