Nuclear phospholipase C beta1 and cellular differentiation. (Articolo in rivista)

Type
Label
  • Nuclear phospholipase C beta1 and cellular differentiation. (Articolo in rivista) (literal)
Anno
  • 2008-01-01T00:00:00+01:00 (literal)
Alternative label
  • Faenza I, Bregoli L, Ramazzotti G, Gaboardi G, Follo MY, Mongiorgi S, Billi AM, Manzoli L, Martelli AM, Cocco L. (2008)
    Nuclear phospholipase C beta1 and cellular differentiation.
    in Frontiers in bioscience (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Faenza I, Bregoli L, Ramazzotti G, Gaboardi G, Follo MY, Mongiorgi S, Billi AM, Manzoli L, Martelli AM, Cocco L. (literal)
Pagina inizio
  • 2452 (literal)
Pagina fine
  • 2463 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 13 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Cellular Signalling Laboratory, Department of Anatomical Sciences, University of Bologna, Bologna, Italy, Institute of Hematology and Medical Oncology 'L. e A. Seràgnoli', University of Bologna, Bologna, Italy; Hematology Unit, Ospedale Civile di Piacenza; Piacenza, Italy; Istituto per i Trapianti d'Organo e l'Immunocitologia del C.N.R., Sezione di Bologna c/o I.O.R., Bologna, Italy. (literal)
Titolo
  • Nuclear phospholipase C beta1 and cellular differentiation. (literal)
Abstract
  • Phosphoinositides (PI) are the most extensively studied lipids involved in cell signaling pathways. The bulk of PI is found in membranes where they are substrates for enzymes, such as kinases, phosphatases and phospholipases, which respond to the activation by cell-surface receptors. The outcome of the majority of signaling pathways involving lipid second messengers results in nuclear responses finally driving the cell into differentiation, proliferation or apoptosis. Some of these pathways are well established, such as that of PI-specific phospholipase C (PI-PLC), which cleaves phosphatidylinositol-4,5-bisphosphate (PIP2) into the two second messengers diacylglycerol (DAG) and inositol-1,4,5-trisphosphate (IP3). Two independent cycles of PI are present inside the cell. One is localized at the plasma membrane, while the most recently discovered PI cycle is found inside the nuclear compartment. The regulation of the nuclear PI pool is totally independent from the plasma membrane counterpart, suggesting that the nucleus constitutes a functionally distinct compartment of inositol lipids metabolism. In this report we will focus on the signal transduction-related metabolism of nuclear PI and review the most convincing evidence that the PI cycle is involved in differentiation programs in several cell systems. (literal)
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