Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity. (Articolo in rivista)

Type
Label
  • Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity. (Articolo in rivista) (literal)
Anno
  • 2013-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1093/hmg/ddt104 (literal)
Alternative label
  • Diana L. Cousminer1,Diane J. Berry4, Nicholas J. Timpson5, Wei Ang7, Elisabeth Thiering8, Enda M. Byrne9, H. Rob Taal10,11,12, Ville Huikari13, Jonathan P. Bradfield15, Marjan Kerkhof17, Maria M. Groen-Blokhuis19, Eskil Kreiner-Møller20, Marcella Marinelli21,22,23, Claus Holst24, Jaakko T. Leinonen1, John R.B. Perry25,26,28, Ida Surakka1,29,Olli Pietiläinen1,31 Johannes Kettunen1,29, Verneri Anttila1,31,35,52,Marika Kaakinen13,14,Ulla Sovio32,34, Anneli Pouta14, Shikta Das32, Vasiliki Lagou26,27, Chris Power4, Inga Prokopenko26,27, David M. Evans5, John P. Kemp5,6, Beate St Pourcain6,Susan Ring6, Aarno Palotie1,31,35, Eero Kajantie29,49, Clive Osmond36, Terho Lehtimäki37, Jorma S. Viikari38, Mika Kähönen39, Nicole M. Warrington7,Stephen J. Lye40, Lyle J. Palmer40,41, Carla M.T. Tiesler8,42, Claudia Flexeder8, Grant W. Montgomery9, Sarah E. Medland9, Albert Hofman10,11, Hakon Hakonarson15,16,43, Mònica Guxens21,22,23, Meike Bartels19, Veikko Salomaa29, The ReproGen Consortium+, Joanne M. Murabito44,Jaakko Kaprio1,2,30, Thorkild I.A. Sørensen24,45, Ferran Ballester23,46,47, Hans Bisgaard20, Dorret I. Boomsma19, Gerard H. Koppelman18, Struan F.A. Grant15,16,43, Vincent W.V. Jaddoe10,11,12, Nicholas G. Martin9, Joachim Heinrich8, Craig E. Pennell7, Olli T. Raitakari39, Johan G. Eriksson3,29,48,51, George Davey Smith5, Elina Hyppönen4, Marjo-Riitta Järvelin13,14,33,53,5 Mark I. McCarthy26,27,5 Samuli Ripatti1,29,31, Elisabeth Widén1,*, for the Early Growth Genetics (EGG) Consortium+. Collaborators (283) (2013)
    Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity.
    in Human molecular genetics (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Diana L. Cousminer1,Diane J. Berry4, Nicholas J. Timpson5, Wei Ang7, Elisabeth Thiering8, Enda M. Byrne9, H. Rob Taal10,11,12, Ville Huikari13, Jonathan P. Bradfield15, Marjan Kerkhof17, Maria M. Groen-Blokhuis19, Eskil Kreiner-Møller20, Marcella Marinelli21,22,23, Claus Holst24, Jaakko T. Leinonen1, John R.B. Perry25,26,28, Ida Surakka1,29,Olli Pietiläinen1,31 Johannes Kettunen1,29, Verneri Anttila1,31,35,52,Marika Kaakinen13,14,Ulla Sovio32,34, Anneli Pouta14, Shikta Das32, Vasiliki Lagou26,27, Chris Power4, Inga Prokopenko26,27, David M. Evans5, John P. Kemp5,6, Beate St Pourcain6,Susan Ring6, Aarno Palotie1,31,35, Eero Kajantie29,49, Clive Osmond36, Terho Lehtimäki37, Jorma S. Viikari38, Mika Kähönen39, Nicole M. Warrington7,Stephen J. Lye40, Lyle J. Palmer40,41, Carla M.T. Tiesler8,42, Claudia Flexeder8, Grant W. Montgomery9, Sarah E. Medland9, Albert Hofman10,11, Hakon Hakonarson15,16,43, Mònica Guxens21,22,23, Meike Bartels19, Veikko Salomaa29, The ReproGen Consortium+, Joanne M. Murabito44,Jaakko Kaprio1,2,30, Thorkild I.A. Sørensen24,45, Ferran Ballester23,46,47, Hans Bisgaard20, Dorret I. Boomsma19, Gerard H. Koppelman18, Struan F.A. Grant15,16,43, Vincent W.V. Jaddoe10,11,12, Nicholas G. Martin9, Joachim Heinrich8, Craig E. Pennell7, Olli T. Raitakari39, Johan G. Eriksson3,29,48,51, George Davey Smith5, Elina Hyppönen4, Marjo-Riitta Järvelin13,14,33,53,5 Mark I. McCarthy26,27,5 Samuli Ripatti1,29,31, Elisabeth Widén1,*, for the Early Growth Genetics (EGG) Consortium+. Collaborators (283) (literal)
Pagina inizio
  • 2735 (literal)
Pagina fine
  • 2747 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 22 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 13 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1Institute for Molecular Medicine, Finland (FIMM), 2Department of Public Health, 3Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland, 4Centre for Paediatric Epidemiology and Biostatistics, MRC Centre for Epidemiology of Child Health, UCL Institute of Child Health, London, UK, 5The Medical Research Council (MRC) Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, 6School of Social and Community Medicine, University of Bristol, Bristol, UK 7School of Women's and Infants' Health, The University of Western Australia, Perth, WA, Australia, 8Institute of Epidemiology I, Helmholtz Zentrum München-- German Research Center for Environmental Health, Neuherberg, Germany, 9Queensland Institute of Medical Research, Brisbane, Australia, 10The Generation R Study Group, 11Department of Epidemiology, 12Department of Pediatrics, Erasmus Medical Center, Rotterdam, The Netherlands, 13Institute of Health Sciences, 14Biocenter Oulu, University of Oulu, Oulu, PO Box 5000, FI-90014, Finland, 15Center for Applied Genomics, 16Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA, 17Department of Epidemiology, 18Department of Pediatric Pulmonology and Pediatric Allergology, GRIAC Research Institute, Beatrix Children's Hospital, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands, 19Netherlands Twin Register, Department of Biological Psychology, VU University, Amsterdam, The Netherlands, 20Copenhagen Prospective Studies on Asthma in Childhood, Health Sciences, University of Copenhagen, Copenhagen University Hospital, Gentofte, Denmark, 21Center for Research in Environmental Epidemiology (CREAL), Barcelona, Catalonia, Spain, 22Hospital del Mar Research Institute (IMIM), Barcelona, Catalonia, Spain, 23CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona, Catalonia, Spain, 24Institute of Preventive Medicine, Copenhagen University Hospital, Copenhagen, Denmark, 25Genetics of Complex Traits, Exeter medical school, University of Exeter, Exeter, UK, 26Wellcome Trust Centre for Human Genetics, 27Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK, 28Department of Twin Research and Genetic Epidemiology, King's College London, London, UK, 29Department of Chronic Disease Prevention, 30Department of Mental Health & Substance Abuse Services, National Institute for Health and Welfare, Helsinki, Finland, 31The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 32Department of Epidemiology and Biostatistics, School of Public Health, 33Department of Epidemiology and Biostatistics, MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College, London, UK, 34Department of Non-communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK, 35Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA, 36MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK, 37Department of Clinical Chemistry, Fimlab Laboratories, University Hospital and University of Tampere, Finland, 38Department of Medicine, 39Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Finland, 40Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada, 41Ontario Institute for Cancer Research, Toronto, Ontario, Canada, 42Division of Metabolic Diseases and Nutritional Medicine, Ludwig-Maximilians-University of Munich, Dr von Hauner Children's Hospital, Munich, Germany, 43Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA, 44Department of Medicine, Section of General Internal Medicine, Boston University School of Medicine, Boston, MA, USA, 45The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark, 46Division of Environment and Health, Center for Public Health Research (CSISP), Valencia, Spain, 47School of Nursing, University of Valencia, Valencia, Spain, 48Unit of General Practice, 49Hospital for Children and Adolescents, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland, 50Oxford NIHR Biomedical Research Centre, Churchill Hospital, Oxford OX3 7LJ, UK, 51Folkhalsan Research Centre, Helsinki, Finland, 52Analytical and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA 53Unit of Primary Care, Oulu University Hospital, Kajaanintie 50, PO Box 20, FI-90220 Oulu, 90029 OYS, Finland, 54Department of Children and Young People and Families, National Institute for Health and Welfare, Aapistie 1, Box 310, FI-90101 Oulu, Finland (literal)
Titolo
  • Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity. (literal)
Abstract
  • The pubertal height growth spurt is a distinctive feature of childhood growth reflecting both the central onset of puberty and local growth factors. Although little is known about the underlying genetics, growth variability during puberty correlates with adult risks for hormone-dependent cancer and adverse cardiometabolic health. The only gene so far associated with pubertal height growth, LIN28B, pleiotropically influences childhood growth, puberty and cancer progression, pointing to shared underlying mechanisms. To discover genetic loci influencing pubertal height and growth and to place them in context of overall growth and maturation, we performed genome-wide association meta-analyses in 18 737 European samples utilizing longitudinally collected height measurements. We found significant associations (P < 1.67 × 10(-8)) at 10 loci, including LIN28B. Five loci associated with pubertal timing, all impacting multiple aspects of growth. In particular, a novel variant correlated with expression of MAPK3, and associated both with increased prepubertal growth and earlier menarche. Another variant near ADCY3-POMC associated with increased body mass index, reduced pubertal growth and earlier puberty. Whereas epidemiological correlations suggest that early puberty marks a pathway from rapid prepubertal growth to reduced final height and adult obesity, our study shows that individual loci associating with pubertal growth have variable longitudinal growth patterns that may differ from epidemiological observations. Overall, this study uncovers part of the complex genetic architecture linking pubertal height growth, the timing of puberty and childhood obesity and provides new information to pinpoint processes linking these traits. (literal)
  • Gli autori dell'IRGB sono inclusi tra i collaboratori all'interno del The ReproGen Consortium (literal)
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