A common biological basis of obesity and nicotine addiction. (Articolo in rivista)

Type
Label
  • A common biological basis of obesity and nicotine addiction. (Articolo in rivista) (literal)
Anno
  • 2013-01-01T00:00:00+01:00 (literal)
Alternative label
  • T E Thorgeirsson,1,* D F Gudbjartsson,1 P Sulem,1 S Besenbacher,1,2 U Styrkarsdottir,1 G Thorleifsson,1 G B Walters,1 TAG Consortium9, Oxford-GSK Consortium9, ENGAGE consortium9, H Furberg,3 P F Sullivan,4 J Marchini,5,6 M I McCarthy,5,7 V Steinthorsdottir,1 U Thorsteinsdottir,1,8 and K Stefansson1,8,*. Collaborators (281). (2013)
    A common biological basis of obesity and nicotine addiction.
    in Translational psychiatry
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • T E Thorgeirsson,1,* D F Gudbjartsson,1 P Sulem,1 S Besenbacher,1,2 U Styrkarsdottir,1 G Thorleifsson,1 G B Walters,1 TAG Consortium9, Oxford-GSK Consortium9, ENGAGE consortium9, H Furberg,3 P F Sullivan,4 J Marchini,5,6 M I McCarthy,5,7 V Steinthorsdottir,1 U Thorsteinsdottir,1,8 and K Stefansson1,8,*. Collaborators (281). (literal)
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  • Gli autori dell'IRGB sono inclusi tra i collaboratori all'interno del Oxford-GSK Consortium (literal)
Rivista
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  • 1Decode genetics/AMGEN, Sturlugata 8, Reykjavik, Iceland 2Bioinformatics Research Centre, Aarhus University, Aarhus, Denmark 3Department of Epidemiology, Memorial Sloan Kettering Cancer Center, NY, USA 4Departments of Genetics and Psychiatry, CB# 7264, 5097 Genomic Medicine, NC, USA 5Wellcome Trust Centre of Human Genetics, Oxford, UK 6Department of Statistics, University of Oxford, Oxford, UK 7Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK 8Faculty of Medicine, University of Iceland, Reykjavik, Iceland *Decode genetics/AMGEN, Sturlugata 8, 101 Reykjavík, Iceland. E-mail: kstefans@decode.is or ; Email: thorgeir@decode.is 9The collaborators from these consortia are listed in a section entitled CONSORTIA. (literal)
Titolo
  • A common biological basis of obesity and nicotine addiction. (literal)
Abstract
  • Smoking influences body weight such that smokers weigh less than non-smokers and smoking cessation often leads to weight increase. The relationship between body weight and smoking is partly explained by the effect of nicotine on appetite and metabolism. However, the brain reward system is involved in the control of the intake of both food and tobacco. We evaluated the effect of single-nucleotide polymorphisms (SNPs) affecting body mass index (BMI) on smoking behavior, and tested the 32 SNPs identified in a meta-analysis for association with two smoking phenotypes, smoking initiation (SI) and the number of cigarettes smoked per day (CPD) in an Icelandic sample (N=34,216 smokers). Combined according to their effect on BMI, the SNPs correlate with both SI (r=0.019, P=0.00054) and CPD (r=0.032, P=8.0 × 10(-7)). These findings replicate in a second large data set (N=127,274, thereof 76,242 smokers) for both SI (P=1.2 × 10(-5)) and CPD (P=9.3 × 10(-5)). Notably, the variant most strongly associated with BMI (rs1558902-A in FTO) did not associate with smoking behavior. The association with smoking behavior is not due to the effect of the SNPs on BMI. Our results strongly point to a common biological basis of the regulation of our appetite for tobacco and food, and thus the vulnerability to nicotine addiction and obesity. (literal)
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