Induction and survival of binucleated Purkinje neurons by selective damage and aging. (Articolo in rivista)

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Label
  • Induction and survival of binucleated Purkinje neurons by selective damage and aging. (Articolo in rivista) (literal)
Anno
  • 2007-01-01T00:00:00+01:00 (literal)
Alternative label
  • Magrassi L (1, 2), Grimaldi P (4), Ibatici A (5), Corselli M(5), Ciardelli L (3), Castello S (5), Podestà M (5), Frassoni F (5), Rossi F (4) (2007)
    Induction and survival of binucleated Purkinje neurons by selective damage and aging.
    in The Journal of neuroscience
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Magrassi L (1, 2), Grimaldi P (4), Ibatici A (5), Corselli M(5), Ciardelli L (3), Castello S (5), Podestà M (5), Frassoni F (5), Rossi F (4) (literal)
Pagina inizio
  • 9885 (literal)
Pagina fine
  • 9892 (literal)
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  • 27 (literal)
Rivista
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  • 8 (literal)
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  • 37 (literal)
Note
  • PubMe (literal)
  • Scopu (literal)
  • Google Scholar (literal)
  • ISI Web of Science (WOS) (literal)
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  • 1) Istituto di Genetica Molecolare CNR, Pavia 2) Neurochirurgia Dipartimento Scienze Chirurgiche, Universita` di Pavia, Fondazione Instituto di Ricovero e Curaio a Carattere Scientifico Policlinico S. Matteo 3) Laboratorio Immunologia Neonatale, Laboratorio Sperimentale di Ricerca Area trapiantologica, Fondazione Instituto di Ricovero e Cura a Carattere Scientifico Policlinico S. Matteo, 27100 Pavia, Italy, 4) Rita Levi Montalcini Center for Brain Repair, National Institute of Neuroscience, Dipartmento di Neuroscienze, Sez. di Fisiologia, Universita` di Torino, I-10125 Torino, Italy, and 5) Centro Cellule Staminali e Terapia Cellulare, Divisione di Ematologia, Ospedale San Martino, 16100 Genova, Italy (literal)
Titolo
  • Induction and survival of binucleated Purkinje neurons by selective damage and aging. (literal)
Abstract
  • Fusion of bone marrow-derived cells with adult Purkinje cells in the cerebellum gives rise to binucleated Purkinje cells. Whether fusion can be modulated by epigenetic factors and whether fused neurons are stable has remained unclear. Here, we show that in mice and rats, partial ablation of Purkinje cells and local microglial activation in the absence of structural damage to the cerebellum increase the rate of fusion. Moreover, mouse Purkinje cells once fused with bone marrow-derived cells are viable for at least 7 months. We also show that cerebellar irradiation is unnecessary for the generation of binucleated Purkinje cells after bone marrow grafting. Moreover, binucleated Purkinje cells can be found in aged mice that did not receive any treatment, suggesting that fusion events occasionally occur throughout the whole lifespan of healthy, unmanipulated individuals. However, in aged chimeric mice that, after bone marrow transplant, have the majority of their nucleated blood cells fluorescent, the number of binucleated fluorescent Purkinje cells is two orders of magnitude less than the total number of binucleated Purkinje cells. (literal)
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