Immunophenotypic, cytogenetic and functional characterization of circulating of endothelial cells in myelodysplastics syndromes (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Immunophenotypic, cytogenetic and functional characterization of circulating of endothelial cells in myelodysplastics syndromes (Articolo in rivista) (literal)

Anno

• 2008-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1038/sj.leu.2405069 (literal)

Alternative label

• Della Porta MG, Malcovati L, Rigolin GM, Rosti V, Bonetti E, Travaglino E, Boveri E, Gallì A, Boggi S, Ciccone M, Pramparo T, Mazzini G, Invernizzi R, Lazzarino M, Cazzola M. (2008)
  Immunophenotypic, cytogenetic and functional characterization of circulating of endothelial cells in myelodysplastics syndromes
  in Leukemia
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Della Porta MG, Malcovati L, Rigolin GM, Rosti V, Bonetti E, Travaglino E, Boveri E, Gallì A, Boggi S, Ciccone M, Pramparo T, Mazzini G, Invernizzi R, Lazzarino M, Cazzola M. (literal)

Pagina inizio

• 530 (literal)

Pagina fine

• 537 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.nature.com/leu/journal/v22/n3/full/2405069a.html (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 22 (literal)

Rivista

• Leukemia (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

• 1–8 2007 Nature Publishing Group All rights reserved 0887-6924/07 .00 www.nature.com/leu (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Division of Hematology, University of Pavia and Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Hematology Section, Department of Biomedical Sciences, University of Ferrara, Ferrara, Italy; Laboratory of Organ Transplantation, University of Pavia and Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Department of Internal Medicine and Medical Oncology, University of Pavia and Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; 5Depatment of Human Pathology, University of Pavia and Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Medical Genetics, University of Pavia and Fondazione IRCCS Policlinico San Matteo, Pavia, Italy and Institute of Molecular Genetics - Histochemistry and Cytometry Section, CNR, Pavia, Italy (literal)

Titolo

• Immunophenotypic, cytogenetic and functional characterization of circulating of endothelial cells in myelodysplastics syndromes (literal)

Abstract

• Circulating endothelial cells (CECs) are associated with neoangiogenesis in various malignant disorders. Using flow cytometry, we studied CECs in 128 patients with myelodysplastic syndrome (MDS). MDS patients had higher CEC levels than controls (Po0.001), and an inverse relationship was found between CECs and international prognostic scoring system risk (r¼_0.55, Po0.001). There was a positive correlation between marrow microvessel density and CECs, low-risk patients showing the strongest association (r1/40.62, Po0.001). We calculated a progenitor-to-mature CEC ratio, which was higher in MDS patients than in healthy subjects (Po0.001), the highest values were found at diagnosis. CECs assessed by flow cytometry positively correlated with the ability to produce endothelial colony-forming cells in vitro (ECFCs; r¼0.57, P¼0.021), which was significantly higher in MDS patients than in controls (P¼0.011). Fluorescence in situ hybridization analysis showed that a variable proportion of CECs (from 40 to 84%) carried the same chromosomal aberration as the neoplastic clone, while endothelial cells isolated from in vitro assays were negative. This study suggests that CECs reflect the abnormal angiogenesis found in MDS, especially in the early stages of the disease. The increased number of functional endothelial progenitor cells in MDS strengthens the rationale for therapeutic interventions aimed at restoring a normal interaction between hematopoietic progenitors and marrow microenvironment. (literal)

Prodotto di

• Sviluppi metodologici in citometria e applicazioni alla sperimentazione biomedica; in vitro imaging (ME.P06.010.001) (Modulo)
• Institute of molecular genetics (IGM) (Istituto)

Autore CNR

• GIULIANO MAZZINI (Persona)

Insieme di parole chiave

• Parole chiave di "Immunophenotypic, cytogenetic and functional characterization of circulating of endothelial cells in myelodysplastics syndromes" (Insieme di parole chiave)

Incoming links:

Prodotto

• Institute of molecular genetics (IGM) (Istituto)
• Sviluppi metodologici in citometria e applicazioni alla sperimentazione biomedica; in vitro imaging (ME.P06.010.001) (Modulo)

Autore CNR di

• GIULIANO MAZZINI (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Leukemia (Rivista)

Insieme di parole chiave di

• Parole chiave di "Immunophenotypic, cytogenetic and functional characterization of circulating of endothelial cells in myelodysplastics syndromes" (Insieme di parole chiave)