Nuclear diacylglycerol kinases: emerging downstream regulators in cell signaling networks. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Nuclear diacylglycerol kinases: emerging downstream regulators in cell signaling networks. (Articolo in rivista) (literal)

Anno

• 2007-01-01T00:00:00+01:00 (literal)

Alternative label

• Evangelisti C, Bortul R, Falà F, Tabellini G, Goto K, Martelli AM. (2007)
  Nuclear diacylglycerol kinases: emerging downstream regulators in cell signaling networks.
  in Histology and histopathology
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Evangelisti C, Bortul R, Falà F, Tabellini G, Goto K, Martelli AM. (literal)

Pagina inizio

• 573 (literal)

Pagina fine

• 579 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 22 (literal)

Rivista

• Histology and histopathology (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Department of Human Anatomical Sciences, University of Bologna, Bologna, Italy; Department of Biomedicine, University of Trieste, Trieste, Italy; Department of Biomedical Sciences and Biotechnology, University of Brescia, Brescia, Italy; Department of Anatomy and Cell Biology, Yamagata University School of Medicine, Yamagata, Japan and Institute for Organ Transplantation and Immunocytology of C.N.R., c/o I.O.R., Bologna, Italy. (literal)

Titolo

• Nuclear diacylglycerol kinases: emerging downstream regulators in cell signaling networks. (literal)

Abstract

• There exists an active lipid metabolism in the nucleus, which is regulated differentially from the lipid metabolism taking place elsewhere in the cell. Evidence has been accumulated that nuclear lipid metabolism is closely involved in a variety of cell responses, including proliferation, differentiation, and apoptosis. A fundamental lipid second messenger which is generated in the nucleus is diacylglycerol, that is mainly known for its role as an activator of some protein kinase C isoforms. Diacylglycerol kinases attenuate diacylglycerol signaling by converting this lipid to phosphatidic acid, which also has signaling functions. Ten mammalian diacylglycerol kinase isoforms have been cloned so far, and some of them are found also in the nucleus, either as resident proteins or after migration from cytoplasm in response to various agonists. Experiments using cultured cells have demonstrated that nuclear diacylglycerol kinases have prominent roles in cell cycle regulation and differentiation. In this review, the emerging roles played by diacylglycerol kinases in the nucleus, such as the control of G1/S phase transition, are discussed. (literal)

Prodotto di

• Bersagli molecolari per il controllo della progressione tumorale (ME.P03.012.001) (Modulo)
• Institute of molecular genetics (IGM) (Istituto)

Autore CNR

• Alberto Maria Martelli (Unità di personale esterno)

Incoming links:

Prodotto

• Institute of molecular genetics (IGM) (Istituto)
• Bersagli molecolari per il controllo della progressione tumorale (ME.P03.012.001) (Modulo)

Autore CNR di

• Alberto Maria Martelli (Unità di personale esterno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Histology and histopathology (Rivista)