Conformationally altered p53: a novel Alzheimer's disease marker? (Articolo in rivista)

Type
Label
  • Conformationally altered p53: a novel Alzheimer's disease marker? (Articolo in rivista) (literal)
Anno
  • 2008-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1038/sj.mp.4002060 (literal)
Alternative label
  • Lanni C; Racchi M; Mazzini G; Ranzenigo A; Polotti R; Sinforiani E; Olivari L; Barcikowska M; Styczynska M; Kuznicki J; Szybinska A; Govoni S; Memo M; Uberti D (2008)
    Conformationally altered p53: a novel Alzheimer's disease marker?
    in Molecular psychiatry
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Lanni C; Racchi M; Mazzini G; Ranzenigo A; Polotti R; Sinforiani E; Olivari L; Barcikowska M; Styczynska M; Kuznicki J; Szybinska A; Govoni S; Memo M; Uberti D (literal)
Pagina inizio
  • 641 (literal)
Pagina fine
  • 647 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni
  • L'importanza pratica dei risultati di questo lavoro e' particolarmente importante in quanto propone una nuova metodologia di diagnosi precoce di sindromi neurodegenerative valutata in modo assolutamente \"non-invasivo\" ovvero sui linfociti del sangue periferico di potenziali pazienti. (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 13 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 6 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Department of Experimental and Applied Pharmacology, Centre of Excellence in Applied Biology, University of Pavia, Pavia, Italy; IGM CNR, Histochemistry and Cytometry, University of Pavia, Pavia, Italy; Department of Geriatric Medicine, Ospedale S Orsola Fatebenefratelli, Brescia, Italy; Laboratory of Neuropsychology, IRCCS Fondazione ‘Casimiro MondinoÂ’, Pavia, Italy; Department of Biomedical Sciences and Biotechnologies, University of Brescia, Brescia, Italy; Medical Research Center Polish Academy of Science, Warszawa, Poland; Laboratory of Neurodegeneration, International Institute of Molecular and Cell Biology, Laboratory of Neurodegeneration, International Institute of Molecular and Cell Biology, Warszawa, Poland and Nencki Institute of Experimental Biology, Warszawa, Poland. (literal)
Titolo
  • Conformationally altered p53: a novel Alzheimer's disease marker? (literal)
Abstract
  • The identification of biological markers of Alzheimer's disease (AD) can be extremely useful to improve diagnostic accuracy and/or to monitor the efficacy of putative therapies. In this regard, peripheral cells may be of great importance, because of their easy accessibility. After subjects were grouped according to diagnosis, the expression of conformationally mutant p53 in blood cells was compared by immunoprecipitation or by a cytofluorimetric assay. In total, 104 patients with AD, 92 age-matched controls, 15 patients with Parkinson's disease and 9 with other types of dementia were analyzed. Two independent methods to evaluate the differential expression of a conformational mutant p53 were developed. Mononuclear cells were analyzed by immunoprecipitation or by flow-cytometric analysis, following incubation with a conformation-specific p53 antibody, which discriminates unfolded p53 tertiary structure. Mononuclear cells from AD patients express a higher amount of mutant-like p53 compared to non-AD subjects, thus supporting the study of conformational mutant p53 as a new putative marker to discriminate AD from non-AD patients. We also observed a strong positive correlation between the expression of p53 and the age of patients. The expression of p53 was independent from the length of illness and from the Mini Mental State Examination value.Molecular Psychiatry advance online publication, 7 August 2007; doi:10.1038/sj.mp.4002060 (literal)
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