Poly(ADP-ribose) polymerase cleavage during apoptosis: when and where? (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Poly(ADP-ribose) polymerase cleavage during apoptosis: when and where? (Articolo in rivista) (literal)

Anno

• 2001-01-01T00:00:00+01:00 (literal)

Alternative label

• Soldani C, Lazze MC, Bottone MG, Tognon G, Biggiogera M, Pellicciari CE, Scovassi AI. (2001)
  Poly(ADP-ribose) polymerase cleavage during apoptosis: when and where?
  in Experimental cell research
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Soldani C, Lazze MC, Bottone MG, Tognon G, Biggiogera M, Pellicciari CE, Scovassi AI. (literal)

Pagina inizio

• 193 (literal)

Pagina fine

• 201 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 269 (literal)

Rivista

• Experimental cell research (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• IGM; UNIPV (literal)

Titolo

• Poly(ADP-ribose) polymerase cleavage during apoptosis: when and where? (literal)

Abstract

• Poly(ADP-ribose) polymerase-1 (PARP-1) plays the active role of \"nick sensor\" during DNA repair and apoptosis, when it synthesizes ADP-ribose from NAD(+) in the presence of DNA strand breaks. Moreover, PARP-1 becomes a target of apoptotic caspases, which originate two proteolytic fragments of 89 and 24 kDa. The precise relationship between PARP-1 activation and degradation during apoptosis is still a matter of debate. In human Hep-2 cells driven to apoptosis by actinomycin D, we have monitored PARP-1 activity by the mAb 10H, which is specific for the ADP-ribose polymers, and we have observed that poly(ADP-ribose) synthesis is a very early response to the apoptotic stimulus. The analysis of the presence and fate of the p89 proteolytic fragment revealed that PARP-1 proteolysis by caspases is concomitant with poly(ADP-ribose) synthesis and that p89 migrates from the nucleus into the cytoplasm in late apoptotic cells with advanced nuclear fragmentation. Copyright 2001 Academic Press. (literal)

Prodotto di

• Institute of molecular genetics (IGM) (Istituto)

Autore CNR

• ANNA SCOVASSI (Unità di personale interno)
• Marco Biggiogera (Unità di personale esterno)
• Maria Grazia Bottone (Persona)

Incoming links:

Prodotto

• Institute of molecular genetics (IGM) (Istituto)

Autore CNR di

• ANNA SCOVASSI (Unità di personale interno)
• Marco Biggiogera (Unità di personale esterno)
• Maria Grazia Bottone (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Experimental cell research (Rivista)