N-type perylene-based organic semiconductors for functional neural interfacing (Articolo in rivista)

Type
Label
  • N-type perylene-based organic semiconductors for functional neural interfacing (Articolo in rivista) (literal)
Anno
  • 2013-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1039/c3tb20555j (literal)
Alternative label
  • Stefano Toffanin, Valentina Benfenati, Assunta Pistone, Simone Bonetti, Wouter Koopman, Tamara Posati, Anna Sagnella, Marco Natali, Roberto Zamboni, Giampiero Ruani and Michele Muccini (2013)
    N-type perylene-based organic semiconductors for functional neural interfacing
    in Journal of Materials Chemistry B
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Stefano Toffanin, Valentina Benfenati, Assunta Pistone, Simone Bonetti, Wouter Koopman, Tamara Posati, Anna Sagnella, Marco Natali, Roberto Zamboni, Giampiero Ruani and Michele Muccini (literal)
Pagina inizio
  • 3850 (literal)
Pagina fine
  • 3859 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://pubs.rsc.org/en/content/articlelanding/2013/tb/c3tb20555j#!divAbstract (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 1 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 10 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 31 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Istituto per lo Studio dei Materiali Nanostrutturati, Consiglio Nazionale delleRicerche (ISMN-CNR), Via Gobetti 101, 40129 Bologna, Italy. Istituto per la Sintesi Organica e Fotoreattivit`a, Consiglio Nazionale delle Ricerche (ISOF-CNR), Via Gobetti 101, 40129 Bologna, Italy. Laboratorio di Micro e Submicro Tecnologie abilitanti dell'Emilia-Romagna (MIST E-R), Via Gobetti 101, 40129 Bologna, Italy ETC srl, Via Gobetti 101, 40129 Bologna, Italy (literal)
Titolo
  • N-type perylene-based organic semiconductors for functional neural interfacing (literal)
Abstract
  • The bioelectrical signalling within neural networks has to be monitored in real-time and localized in space in order to unravel the mechanisms behind pathologies and diseases of the nervous systems. Organic materials have significant potential for bio-functional neural interfacing given that their \"soft\" nature offers better mechanical compatibility with the nerve tissues than conventional semiconductors, and their flexibility allows realization of the non-planar forms typically required for biomedical implants. The integration of living cells into organic semiconductors is an important step towards the development of bio-organic electronic transducers of cellular activity from neurons. Here, we report on the use and characterization of n-type perylene derivatives as a suitable interface platform for organic neuroelectronic devices. We demonstrate that primary neurons can adhere, grow and differentiate on a suitably engineered perylene-based field-effect transistor platform, while maintaining their firing properties even after a prolonged time of cell-culturing. It is noteworthy that the field-effect transistors preserve their electrical characteristics even after 10 days of incubation in cell culture media. These results validate n-type perylene derivatives as a suitable long-term interface platform for organic neuroelectronic devices, which is particularly relevant in view of the recently reported perylene-based fieldeffect transistor structure capable of providing bidirectional stimulation and recording of primary neurons. (literal)
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