Inibitori dell'interazione TCR/MHCII-Collagen interaction inhibitors useful for the treatment of rheumatoid arthritis (Brevetto)

Type
Label
  • Inibitori dell'interazione TCR/MHCII-Collagen interaction inhibitors useful for the treatment of rheumatoid arthritis (Brevetto) (literal)
Anno
  • 2013-01-01T00:00:00+01:00 (literal)
Alternative label
  • De Rosa M.C., Ria B., Giardina B., Ferraccioli G., Pirolli D., Nicolò C. (2013)
    Inibitori dell'interazione TCR/MHCII-Collagen interaction inhibitors useful for the treatment of rheumatoid arthritis
    (literal)
Titolo
  • Inibitori dell'interazione TCR/MHCII-Collagen interaction inhibitors useful for the treatment of rheumatoid arthritis (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • De Rosa M.C., Ria B., Giardina B., Ferraccioli G., Pirolli D., Nicolò C. (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#proprieta
  • CNR; Univ. Cattolica Sacro Cuore Roma (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://worldwide.espacenet.com/publicationDetails/biblio?CC=WO&NR=2013144931A3&KC=A3&FT=D&ND=&date=20140306&DB=&locale=en_EP (literal)
Http://www.cnr.it/ontology/cnr/brevetti.owl#tipoDiBrevetto
  • Internazionale (literal)
Numero brevetto
  • WO2013144931(A3) (literal)
Anno di deposito
  • 2013 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • CNR-ICMR; Dip. Reumatologica, Univ. Cattolica Sacro Cuore, Roma; Ist. Patologia Gen., Univ. Cattolica Sacro Cuore, Roma; Ist. Biochimica e Bioch. Clinica, Univ. Cattolica Sacro Cuore (literal)
Titolo
  • Inibitori dell'interazione TCR/MHCII-Collagen interaction inhibitors useful for the treatment of rheumatoid arthritis (literal)
Abstract
  • The T cells specific to human collagen type II, one of the possible autoantigens, have a crucial role in the development of rheumatoid arthritis in the context of HLA-DR4. The protein-protein interactions between the T cell receptor (TCR) and the type II collagen linked to the allele MHC of class II HLA-DR4 may thus represent the target for the development of new drugs against rheumatoid arthritis. Using computational virtual screening techniques, families of pharmacologically active molecules have been identified that interfere with the TCR/collagen ll-MHCII interaction. The compounds identified here open up new possibilities in the treatment of rheumatoid arthritis. (literal)
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