http://www.cnr.it/ontology/cnr/individuo/prodotto/ID273545
Computer aided design of FtsZ targeting oligopeptides (Articolo in rivista)
- Type
- Label
- Computer aided design of FtsZ targeting oligopeptides (Articolo in rivista) (literal)
- Anno
- 2013-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1039/c2ra21886k (literal)
- Alternative label
Pieraccini, S; Rendine, S; Jobichen, C; Domadia, P; Sivaraman, J; Francescato, P; Speranza, G; Sironi, M (2013)
Computer aided design of FtsZ targeting oligopeptides
in RSC advances; RSC Publishing, Cambridge (Regno Unito)
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Pieraccini, S; Rendine, S; Jobichen, C; Domadia, P; Sivaraman, J; Francescato, P; Speranza, G; Sironi, M (literal)
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- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
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- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
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- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- University of Milan, Dipartimento Chim, and INSTM UdR, I-20133 Milan, Italy; CNR ISTM, Ist Sci & Tecnol Mol, I-20133 Milan, Italy; Natl Univ Singapore, Dept Biol Sci, Singapore 117543, Singapore (literal)
- Titolo
- Computer aided design of FtsZ targeting oligopeptides (literal)
- Abstract
- FtsZ is a protein involved in the bacterial division process and is thus an emerging target for antibacterial drugs. The network of interactions between FtsZ monomers necessary for exploitation of its biological function are studied here with molecular dynamics and free energy calculations. The results obtained led to the design of FtsZ targeting peptides which exhibited activity against the function of FtsZ in vitro. (literal)
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