DADLE induces a reversible hibernation-like state in HeLa cells. (Articolo in rivista)

Type
Label
  • DADLE induces a reversible hibernation-like state in HeLa cells. (Articolo in rivista) (literal)
Anno
  • 2006-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1007/s00418-005-0085-x (literal)
Alternative label
  • Vecchio L; Soldani C; Bottone MG; Malatesta M; Martin TE; Rothblum LI; Pellicciari C; Biggiogera M. (2006)
    DADLE induces a reversible hibernation-like state in HeLa cells.
    in Histochemistry and cell biology
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Vecchio L; Soldani C; Bottone MG; Malatesta M; Martin TE; Rothblum LI; Pellicciari C; Biggiogera M. (literal)
Pagina inizio
  • 193 (literal)
Pagina fine
  • 201 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 125 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Dipartimento di Biologia Animale ed Istituto di Genetica Molecolare del CNR Pavia (literal)
Titolo
  • DADLE induces a reversible hibernation-like state in HeLa cells. (literal)
Abstract
  • [D-Ala(2)-D-Leu(5)-Enkephalin] (DADLE) can induce hibernation when injected into ground squirrels in summer and is able to increase the survival time of explanted organs such as liver and lung. Since cell metabolism is a target of this peptide, we have treated HeLa cells with DADLE and investigated its possible effect on transcription and proliferation as well as the resumption of metabolic activity after treatment. The labelling for Pol I, Pol II and for splicing factors such as snRNPs and SC-35 decreased after treatment as did the nucleolar labelling for UBF. In treated cells, several spherical nuclear bodies were found to be labelled for hnRNPs. In parallel, the number of proliferating cells decreased after treatment with DADLE. After recovery, there was a gradual resumption of cell function: transcription and splicing factors had a distribution similar to that of controls; proliferation resumed; nuclear bodies, representing storage sites for RNPs, disappeared. (literal)
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