http://www.cnr.it/ontology/cnr/individuo/prodotto/ID27352

Coinfection with HIV-1 and human T-Cell lymphotropic virus type II in intravenous drug users is associated with delayed progression to AIDS. (Articolo in rivista)

Type

Prodotto della ricerca (Classe)
Articolo in rivista (Classe)

Label

Coinfection with HIV-1 and human T-Cell lymphotropic virus type II in intravenous drug users is associated with delayed progression to AIDS. (Articolo in rivista) (literal)

Anno

2006-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

10.1097/01.qai.0000179426.04166.12 (literal)

Alternative label

Turci M; Pilotti E; Ronzi P; Magnani G; Boschini A; Parisi SG; Zipeto D; Lisa A; Casoli C; Bertazzoni U. (2006)
Coinfection with HIV-1 and human T-Cell lymphotropic virus type II in intravenous drug users is associated with delayed progression to AIDS.
in Journal of acquired immune deficiency syndromes (1999); Lippincott Williams & Wilkins, Philadelphia (Stati Uniti d'America)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Turci M; Pilotti E; Ronzi P; Magnani G; Boschini A; Parisi SG; Zipeto D; Lisa A; Casoli C; Bertazzoni U. (literal)

Pagina inizio

100 (literal)

Pagina fine

106 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

http://journals.lww.com/jaids/Fulltext/2006/01010/Coinfection_With_HIV_1_and_Human_T_Cell.16.aspx (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

41 (literal)

Rivista

Journal of acquired immune deficiency syndromes (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

7 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

1 (literal)

Note

PubMe (literal)
Google Scholar (literal)
Scopu (literal)
ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

From the Section of Biology and Genetics, Department of Mother and Child, University of Verona, Verona, Italy; Department of Clinical Medicine, University of Parma, Parma, Italy; Division of Infectious Diseases, Hospital of Reggio Emilia, Reggio Emilia, Italy; S. Patrignano Community, Rimini, Italy; Division of Infectious Diseases, Hospital of Verona, Verona, Italy; and Institute of Molecular Genetics-CNR, Pavia, Italy. (literal)

Titolo

Coinfection with HIV-1 and human T-Cell lymphotropic virus type II in intravenous drug users is associated with delayed progression to AIDS. (literal)

Abstract

Human T-cell lymphotropic virus (HTLV) type II has spread among intravenous drug users (IDUs), many of whom are coinfected with HIV-1. We have investigated the rate of HTLV-II infection in 3574 Italian IDUs screened for HIV-1, HTLV-I, and HTLV-II from 1986 to the present. HTLV-II proviral load was determined by a real-time polymerase chain reaction specifically designed for tax amplification. The frequency of HTLV-II infection was 6.7% among HIV-1-positive subjects and 1.1% among HIV-1-negative subjects (P < 0.0001). For examination of AIDS progression, a group of 437 HIV-1-monoinfected subjects and another group of 96 HIV-1/HTLV-II-coinfected subjects were monitored. Enrollees were matched at entry by CD4 cell counts and followed for an average of 13 years. HIV-1/HTLV-II coinfection was associated with older age (P < 0.0001) and higher CD4 (P < 0.0001) and CD8 (P < 0.001) cell counts compared with monoinfected IDUs. The number of long-term nonprogressors for AIDS was significantly higher (P < 0.0001) among coinfected patients (13 [13.5%] of 96 patients) than HIV monoinfected patients (5 [1.1%] of 437 patients), showing that HTLV-II exerts a protective role. An increased incidence of liver disease and hepatitis C virus positivity among coinfected IDUs was observed. Five coinfected subjects undergoing antiretroviral therapy showed a significant (P < 0.05) increase in HTLV-II proviral load concomitant to a decrease in HIV-1 viremia, suggesting that the treatment is ineffective against HTLV-II infection. (literal)

Editore