Effect of paclitaxel on intracellular localization of c-Myc and P-c-Myc in prostate carcinoma cell lines. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Effect of paclitaxel on intracellular localization of c-Myc and P-c-Myc in prostate carcinoma cell lines. (Articolo in rivista) (literal)

Anno

• 2007-01-01T00:00:00+01:00 (literal)

Alternative label

• Supino R, Favini E, Cuccuru G, Zunino F, Scovassi AI. (2007)
  Effect of paclitaxel on intracellular localization of c-Myc and P-c-Myc in prostate carcinoma cell lines.
  in Annals of the New York Academy of Sciences
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Supino R, Favini E, Cuccuru G, Zunino F, Scovassi AI. (literal)

Pagina inizio

• 175 (literal)

Pagina fine

• 181 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 1095 (literal)

Rivista

• Annals of the New York Academy of Sciences (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#descrizioneSinteticaDelProdotto

• Il lavoro descrive la risposta al paclitaxel di linee cellulari derivate da tumore prostatico. (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• (RS, FE, CG, ZF) Istituto Nazionale per lo Studio e la Cura dei Tumori, Via Venezian 1, 20133 Milano, Italy; (SAI) Istituto di Genetica Molecolare CNR, Via Abbiategrasso 207, 27100 Pavia, Italy (literal)

Titolo

• Effect of paclitaxel on intracellular localization of c-Myc and P-c-Myc in prostate carcinoma cell lines. (literal)

Abstract

• The proto-oncogene c-myc is involved in multiple cell pathways with opposite effects on cell outcome of death or proliferation. It has been proposed that these different roles depend on the sequestration of c-Myc protein in cellular compartments and/or its phosphorylation. We speculated that subcellular localization of c-Myc protein and of its phosphorylated form (P-c-Myc) could have a role in the different response to paclitaxel (PTX) in two prostate carcinoma cell lines, PC3 and DU145, which undergo either multinucleation or c-myc-dependent apoptosis, respectively. c-myc is amplified only in PC3, but a similar extent of c-Myc phosphorylation was observed in both cell lines after PTX treatment. We found that PTX-induced upregulation of c-myc in DU145 cells, not occurring in PC3 cells, cannot be ascribed to a different protein localization, and that a comparable c-Myc and P-c-Myc nuclear translocation occurs in both cell lines after drug treatment. Thus, subcellular localization of c-Myc and P-c-Myc is not crucial in determining the mode of cell death in these prostate carcinoma cell lines. (literal)

Prodotto di

• Institute of molecular genetics (IGM) (Istituto)
• Cromosomi artificiali per terapia genica. Studi sulla replicazione del DNA in cellule umane ; controllo del ciclo cellulare e della proliferazione. (ME.P05.006.001) (Modulo)

Autore CNR

• ANNA SCOVASSI (Unità di personale interno)

Insieme di parole chiave

• Keywords of "Effect of paclitaxel on intracellular localization of c-Myc and P-c-Myc in prostate carcinoma cell lines." (Insieme di parole chiave)

Incoming links:

Prodotto

• Institute of molecular genetics (IGM) (Istituto)
• Cromosomi artificiali per terapia genica. Studi sulla replicazione del DNA in cellule umane ; controllo del ciclo cellulare e della proliferazione. (ME.P05.006.001) (Modulo)

Autore CNR di

• ANNA SCOVASSI (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Annals of the New York Academy of Sciences (Rivista)

Insieme di parole chiave di

• Keywords of "Effect of paclitaxel on intracellular localization of c-Myc and P-c-Myc in prostate carcinoma cell lines." (Insieme di parole chiave)