http://www.cnr.it/ontology/cnr/individuo/prodotto/ID273465

Hybrid iron oxide-copolymer micelles and vesicles as contrast agents for MRI: Impact of the nanostructure on the relaxometric properties (Articolo in rivista)

Type

Articolo in rivista (Classe)
Prodotto della ricerca (Classe)

Label

Hybrid iron oxide-copolymer micelles and vesicles as contrast agents for MRI: Impact of the nanostructure on the relaxometric properties (Articolo in rivista) (literal)

Anno

2013-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

10.1039/c3tb00429e (literal)

Alternative label

0 P. Arosio, J. Thévenot, T. Orlando, F. Orsini, M. Corti, M. Mariani, L. Bordonali, C. Innocenti, C. Sangregorio, H. Oliveira, S. Lecommandoux, A. Lascialfari, O. Sandre (2013)
Hybrid iron oxide-copolymer micelles and vesicles as contrast agents for MRI: Impact of the nanostructure on the relaxometric properties
in Journal of Materials Chemistry B; ROYAL SOC CHEMISTRY, THOMAS GRAHAM HOUSE,, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND (Regno Unito)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

0 P. Arosio, J. Thévenot, T. Orlando, F. Orsini, M. Corti, M. Mariani, L. Bordonali, C. Innocenti, C. Sangregorio, H. Oliveira, S. Lecommandoux, A. Lascialfari, O. Sandre (literal)

Pagina inizio

5317 (literal)

Pagina fine

5328 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

1 (literal)

Rivista

Journal of Materials Chemistry B (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

11 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

39 (literal)

Note

ISI Web of Science (WOS) (literal)
Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

1 ] Univ Milan, Consorzio INSTM, Dipartimento Fis, I-20133 Milan, Italy 2 ] Univ Bordeaux, IPB, ENSCBP, F-33607 Pessac, France 3 ] CNRS, Lab Chim Polymeres Organ UMR5629, Pessac, France 4 ] Univ Pavia, Dipartimento Fis, Consorzio INSTM, CNISM, I-27100 Pavia, Italy 5 ] Univ Pavia, I-27100 Pavia, Italy 6 ] Univ Bologna, Dipartimento Fis & Astron, I-40127 Bologna, Italy 7 ] Univ Firenze, Dipartimento Chim, I-50019 Sesto Fiorentino, Italy 8 ] Consorzio INSTM, I-50019 Sesto Fiorentino, Italy 9 ] CNR, ISTM, I-20133 Milan, Italy 10 ] CNR, Ist Nanosci, Modena, Italy (literal)

Titolo

Hybrid iron oxide-copolymer micelles and vesicles as contrast agents for MRI: Impact of the nanostructure on the relaxometric properties (literal)

Abstract

Magnetic resonance imaging (MRI) is at the forefront of non-invasive medical imaging techniques. It provides good spatial and temporal resolution that can be further improved by the use of contrast agents (CAs), providing a valuable tool for diagnostic purposes. Ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles are attractive MRI contrast agents due to their negative (T-2) contrast enhancement capability and biocompatibility. Clusters of USPIOs with polymer material are of particular interest since they can sustain additional functionalities like drug delivery and targeting. Aiming to establish a relationship between the morphology of the clusters and their efficacy as MRI contrast agents (relaxometric properties), we prepared - using three different maghemite (gamma-Fe2O3) USPIO diameters - a series of hybrid copolymer/iron oxide CAs presenting two different geometries (micellar or vesicular). The NMR relaxometry profiles confirmed the nature of the physical mechanisms inducing the increase of nuclear relaxation rates at low (magnetic anisotropy) and high (Curie relaxation) magnetic fields. A heuristic model, first proposed by Roch, Muller, Gillis, and Brooks, allowed the fitting of the whole longitudinal relaxivity r(1)(v) profile, for samples with different magnetic core sizes. We show that both types of clusters exhibit transverse relaxivity (r(2)) values comparable to or higher than those of common contrast agents, over the whole tested frequency range. Moreover, in-depth analysis revealed substantially a linear relationship between r(2) and the number of encapsulated USPIOs divided by the diameter of the clusters (N-USPIO/D-H), for each USPIO size. The cluster structure (i.e. micelle or vesicle) appeared to have a mild influence on the transverse relaxivity value. Indeed, the r(2) value was mainly governed by the individual size of the USPIOs, correlated with both the cluster external diameter and the magnetic material volume fraction. (literal)

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