The effect of alendronate doped calcium phosphates on bone cells activity (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• The effect of alendronate doped calcium phosphates on bone cells activity (Articolo in rivista) (literal)

Anno

• 2012-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.bone.2012.07.020 (literal)

Alternative label

• Boanini, E.a and Torricelli, P.b and Gazzano, M.c and Fini, M.b and Bigi, A.a (2012)
  The effect of alendronate doped calcium phosphates on bone cells activity
  in Bone (New York, NY)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Boanini, E.a and Torricelli, P.b and Gazzano, M.c and Fini, M.b and Bigi, A.a (literal)

Pagina inizio

• 944 (literal)

Pagina fine

• 952 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni

• cited By (since 1996)2 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.scopus.com/inward/record.url?eid=2-s2.0-84867074995&partnerID=40&md5=4a4af992406c1a6af0aec7c58e6ff41e (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 51 (literal)

Rivista

• Bone (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 5 (literal)

Note

• Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Department of Chemistry G. Ciamician, University of Bologna, Italy; Preclinical and Surgical Studies Laboratory, Codivilla Putti Research Institute-Rizzoli Orthopaedic Institute, Bologna, Italy; ISOF-CNR, C/o Department of Chemistry G. Ciamician, Bologna, Italy (literal)

Titolo

• The effect of alendronate doped calcium phosphates on bone cells activity (literal)

Abstract

• This study demonstrates that octacalcium phosphate (OCP) is a suitable substrate for alendronate local action towards bone cells. The results of the structural, spectroscopic, and microscopic investigation show that soaking OCP into alendronate solutions provoked the deposition of long crystalline rod-shaped formations, most likely a calcium alendronate complex, onto the calcium phosphate. The amount of alendronate loaded onto OCP increased as a function of the bisphosphonate concentration in solution. Osteoblast and osteoclast response was tested in single and in co-cultures on OCP containing 6.4. wt.% AL (OCP-AL), and for comparison on hydroxyapatite (HA) containing a similar amount (5.9. wt.%) of AL (HA-AL), as well as on pure OCP and HA as reference materials. Alendronate loaded materials displayed a beneficial effect on osteoblast activity and differentiation, whereas they inhibited osteoclast proliferation and differentiation. Crosstalking between osteoblast-like MG63 cells and human osteoclasts enhanced their response to alendronate. Moreover, OCP displayed a greater stimulating effect than HA on osteoblast differentiation, and AL promotion of osteoblast differentiation and mineralization was enhanced in OCP-AL with respect to HA-AL. © 2012 Elsevier Inc. (literal)

Prodotto di

• Polimerizzazione radicalica controllata e caratterizzazione avanzata di nuovi materiali polimerici (PRACCAMPO) (PM.P02.016.001) (Modulo)
• Institute for organic syntheses and photoreactivity (ISOF) (Istituto)

Autore CNR

• MASSIMO GAZZANO (Persona)

Insieme di parole chiave

• Keywords of "The effect of alendronate doped calcium phosphates on bone cells activity" (Insieme di parole chiave)

Incoming links:

Prodotto

• Institute for organic syntheses and photoreactivity (ISOF) (Istituto)
• Polimerizzazione radicalica controllata e caratterizzazione avanzata di nuovi materiali polimerici (PRACCAMPO) (PM.P02.016.001) (Modulo)

Autore CNR di

• MASSIMO GAZZANO (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Bone (Rivista)

Insieme di parole chiave di

• Keywords of "The effect of alendronate doped calcium phosphates on bone cells activity" (Insieme di parole chiave)