The effect of zoledronate-hydroxyapatite nanocomposites on osteoclasts and osteoblast-like cells in vitro (Articolo in rivista)

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  • The effect of zoledronate-hydroxyapatite nanocomposites on osteoclasts and osteoblast-like cells in vitro (Articolo in rivista) (literal)
Anno
  • 2012-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.biomaterials.2011.09.092 (literal)
Alternative label
  • Boanini, E.a and Torricelli, P.b and Gazzano, M.c and Fini, M.b and Bigi, A.a (2012)
    The effect of zoledronate-hydroxyapatite nanocomposites on osteoclasts and osteoblast-like cells in vitro
    in Biomaterials
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Boanini, E.a and Torricelli, P.b and Gazzano, M.c and Fini, M.b and Bigi, A.a (literal)
Pagina inizio
  • 722 (literal)
Pagina fine
  • 730 (literal)
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  • cited By (since 1996)5 (literal)
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  • http://www.scopus.com/inward/record.url?eid=2-s2.0-80055110896&partnerID=40&md5=6c3facd1342d0572289a726a1a847941 (literal)
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  • 33 (literal)
Rivista
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  • 2 (literal)
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  • Scopu (literal)
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  • Dept. of Chemistry G. Ciamician, University of Bologna, Italy; Experimental Surgery Department, Research Inst. Codivilla Putti, Rizzoli Orthopaedic Institute, Bologna, Italy; ISOF, CNR, C/o Dept. of Chemistry G. Ciamician, Bologna, Italy (literal)
Titolo
  • The effect of zoledronate-hydroxyapatite nanocomposites on osteoclasts and osteoblast-like cells in vitro (literal)
Abstract
  • This study demonstrates that zoledronate containing hydroxyapatite nanocrystals (HA-ZOL) can be synthesized as a single crystalline phase up to a zoledronate content of about 7 wt% by direct synthesis in aqueous solution, at variance with what previously found for alendronate-hydroxyapatite nanocrystals (HA-AL). On increasing zoledronate incorporation, the length of the coherent crystalline domains and the crystal dimensions of hydroxyapatite decrease, whereas the specific surface area increases. Full profile fitting of the powder X-ray diffraction patterns does not indicate major structural modifications, but an increase of the hydroxyapatite unit cell, on increasing zoledronate content. These data, together with a structural similarity between hydroxyapatite and calcium zoledronate, suggest a preferential interaction between zoledronate and the hydroxyapatite faces parallel to the c-axis direction. Osteoblast-like MG-63 cells and human osteoclasts were cultured on HA-ZOL nanocrystals and as a comparison on HA-AL nanocrystals containing almost the same (about 7 wt%) bisphosphonate amount. The beneficial influence of bisphosphonates on osteoblast proliferation and differentiation is enhanced when the tests are performed in co-cultures. Similarly, the reduction of osteoclast proliferation and the increase of Caspase 3 production are dramatically enhanced in co-cultures, which highlight an even greater influence of HA-ZOL than HA-AL on osteoclast apoptosis. © 2011 Elsevier Ltd. (literal)
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