In situ demonstration of improvement of liver mitochondria function by melatonin after cold ischemia. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• In situ demonstration of improvement of liver mitochondria function by melatonin after cold ischemia. (Articolo in rivista) (literal)

Anno

• 2006-01-01T00:00:00+01:00 (literal)

Alternative label

• Freitas I, Bertone V, Guarnaschelli C, Ferrigno A, Boncompagni E, Rizzo V, Reiter RJ, Barni S, Vairetti M. (2006)
  In situ demonstration of improvement of liver mitochondria function by melatonin after cold ischemia.
  in In vivo (Athens)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Freitas I, Bertone V, Guarnaschelli C, Ferrigno A, Boncompagni E, Rizzo V, Reiter RJ, Barni S, Vairetti M. (literal)

Pagina inizio

• 229 (literal)

Pagina fine

• 237 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 20 (literal)

Rivista

• In vivo (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

• I.F. 2005: 1.037 (literal)

Note

• ISI Web of Science (WOS) (literal)

Titolo

• In situ demonstration of improvement of liver mitochondria function by melatonin after cold ischemia. (literal)

Abstract

• In a previous investigation, reperfusion with a melatonin-containing medium was demonstrated to enhance bile production and tissue ATP levels in rat livers, cold-preserved with University of Wisconsin (UW) or Celsior solutions, with respect to melatonin-free reperfusion; lipid peroxidation products in the perfusate were not influenced by the indole. This was ascribed to an increased efficiency of the hepatocyte mitochondria induced by melatonin. Reactive oxygen species (ROS) normally leak from the electron transfer chain in mitochondria and excessive ROS production is presumed to mediate ischemia-reperfusion (I/R) damage. A histochemical reaction was used to demonstrate ROS on the same model. Compared to the lobular zonation of ROS in control livers, the stained area of cold-preserved livers reperfused without melatonin was restricted to a narrow portal region, in keeping with the much lower ATP content. When reperfusion was performed with melatonin, the liver morphology was improved and the ROS reaction in hepatocytes more intense, though not reaching the control liver pattern. Sinusoidal cells were poorly-stained in both cases. In conclusion, with this different approach, melatonin was confirmed to improve mitochondrial performance and to discriminate parenchymal from sinusoidal cell behavior. Our observations confirm that melatonin mitigates I/R injury and support its potential in liver transplantation. (literal)

Prodotto di

• Sviluppi metodologici in citometria e applicazioni alla sperimentazione biomedica; in vitro imaging (ME.P06.010.001) (Modulo)
• Institute of molecular genetics (IGM) (Istituto)

Autore CNR

• Isabel Freitas (Persona)

Insieme di parole chiave

• Keywords of "In situ demonstration of improvement of liver mitochondria function by melatonin after cold ischemia." (Insieme di parole chiave)

Incoming links:

Prodotto

• Institute of molecular genetics (IGM) (Istituto)
• Sviluppi metodologici in citometria e applicazioni alla sperimentazione biomedica; in vitro imaging (ME.P06.010.001) (Modulo)

Autore CNR di

• Isabel Freitas (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• In vivo (Rivista)

Insieme di parole chiave di

• Keywords of "In situ demonstration of improvement of liver mitochondria function by melatonin after cold ischemia." (Insieme di parole chiave)