http://www.cnr.it/ontology/cnr/individuo/prodotto/ID27231

Sequence variation in the hypervariable Region 1 of hepatitis C virus and posttransplantation recurrent hepatitis (Articolo in rivista)

Type

Articolo in rivista (Classe)
Prodotto della ricerca (Classe)

Label

Sequence variation in the hypervariable Region 1 of hepatitis C virus and posttransplantation recurrent hepatitis (Articolo in rivista) (literal)

Anno

2003-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

10.1053/jlts.2003.50180 (literal)

Alternative label

Silini E; Belli L; Brambilla S; Foti L; Gritti C; Lisa A; Alberti AB; Vinci M; De Carlis L; Rondinara G; Pinzello G. (2003)
Sequence variation in the hypervariable Region 1 of hepatitis C virus and posttransplantation recurrent hepatitis
in Liver transplantation (Print); WB Saunders Co.-Elsevier Inc., Philadelphia (Stati Uniti d'America)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Silini E; Belli L; Brambilla S; Foti L; Gritti C; Lisa A; Alberti AB; Vinci M; De Carlis L; Rondinara G; Pinzello G. (literal)

Pagina inizio

1040 (literal)

Pagina fine

1047 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

http://onlinelibrary.wiley.com/doi/10.1053/jlts.2003.50180/abstract (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

9 (literal)

Rivista

Liver transplantation (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

Impact Factor: 4.242 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

8 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

10 (literal)

Note

ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

Department of Pathology, University and IRCCS-S, Matteo; Hepatology and Gastroenterology Unit Crespi and the Depart-ment of Surgery and Center for Abdominal Organ Transplantation, Niguarda Hospital, Milano; Associazione Studio Avanzato Epatiti Virali, Bonate Sotto (BG); Population Genetics Laboratory, National Research Council, Pavia; Italy. (literal)

Titolo

Sequence variation in the hypervariable Region 1 of hepatitis C virus and posttransplantation recurrent hepatitis (literal)

Abstract

Hepatitis C virus (HCV) shows remarkable genetic variationin both populations and individuals, in whom it circulates as quasispecies (QS). Sequence variation within an infected host has adaptive significance and reflects the modes and intensity of selection mechanisms operating on the virus. We investigated the sequence diversity of hypervariable region 1 of HCV in liver transplant recipients and correlated it with the recurrence of hepatitis. Twenty-six patients were considered during a 2-year period; all had graft reinfection, and 14 patients developed hepatitis recurrence. Cloned sequences were obtained from sera collected before or within 1 month after orthotopic liver transplantation (OLT) and at 3 and 24 months thereafter. Sequence diversity within single sera and over consecutive samples was analyzed quantitatively by matrix comparison and phylogenetic analysis. Propagation of viral QS in the graft was markedly dependent on individual factors. Viral QS in post-OLT sera were less complex and evolved slower compared with immunocompetent subjects with chronic hepatitis. Sequence variation was greater during the first 3 months post-OLT than during the remaining period. Genetic diversity within single samples was not related to hepatitis recurrence or other clinical features. Conversely, sequence diversity over consecutive samples was reduced in patients who experienced hepatitis recurrence, in particular, in those infected with genotype 1b and with an HLA-DR mismatched graft. Selection of viral sequences was markedly impaired in liver transplant recipients and tended to be greater early after OLT. Reduced sequence turnover correlated negatively with the outcome of graft reinfection. (literal)

Editore