Photocontrolled binding of artemisinin to a bis(beta-cyclodextrin) bearing azobenzene on the primary face (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Photocontrolled binding of artemisinin to a bis(beta-cyclodextrin) bearing azobenzene on the primary face (Articolo in rivista) (literal)

Anno

• 2012-01-01T00:00:00+01:00 (literal)

Alternative label

• Anand, R. and Manoli, F. and Vargas-Berenguel, A. and Monti, S. (2012)
  Photocontrolled binding of artemisinin to a bis(beta-cyclodextrin) bearing azobenzene on the primary face
  in Journal of drug delivery science and technology
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Anand, R. and Manoli, F. and Vargas-Berenguel, A. and Monti, S. (literal)

Pagina inizio

• 266 (literal)

Pagina fine

• 269 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 22 (literal)

Rivista

• Journal of drug delivery science and technology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 3 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Anand, R. and Manoli, F. and Monti, S. Istituto per la Sintesi Organica e la Fotoreattività, CNR, Bologna, Italy and Vargas-Berenguel, A. Area de Quimica Organica, Universidad de Almeria, Spain (literal)

Titolo

• Photocontrolled binding of artemisinin to a bis(beta-cyclodextrin) bearing azobenzene on the primary face (literal)

Abstract

• Circular dichroism titrations with multivariate global analysis of multiwavelength data have been used to study the binding behavior of 4,4'-bis(6'-O-cyclomaltoheptaosyl)azobenzene (CyD2-AB). This host system in the trans configuration, 10-4 M in neutral aqueous solution, is able to form a 1:1 complex with artemisinin (ART) with log (K11/M-1) = 4.1 ± 0.1, at 22 °C. Photoirradiation at 363 nm switches the linker from the trans to the cis configuration and the latter shows a loss of interaction with ART. The difference in the binding features between the two geometrical isomers of CyD2-AB suggests light control is possible for ART binding in aqueous solution through the photoisomerization reaction. The binding behavior of this host depends on its concentration. At 10-3 M trans CyD2-AB forms a complex with ART characterized by a 2:1 host:guest stoichiometry and log (K21/M-2) = 6.7 ± 0.3 . (literal)

Prodotto di

• Institute for organic syntheses and photoreactivity (ISOF) (Istituto)
• Studio delle interazioni legando-recettore in sistemi modello mediante metodi spettroscopici e fotofisici (LEGARE) (PM.P06.005.002) (Modulo)

Autore CNR

• SANDRA MONTI (Unità di personale esterno)
• FRANCESCO MANOLI (Persona)
• RESMI ANAND (Persona)

Incoming links:

Prodotto

• Institute for organic syntheses and photoreactivity (ISOF) (Istituto)
• Studio delle interazioni legando-recettore in sistemi modello mediante metodi spettroscopici e fotofisici (LEGARE) (PM.P06.005.002) (Modulo)

Autore CNR di

• FRANCESCO MANOLI (Persona)
• RESMI ANAND (Persona)
• SANDRA MONTI (Unità di personale esterno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of drug delivery science and technology (Rivista)