Hydroxylation of lithocholic acid by selected actinobacteria and filamentous fungi (Articolo in rivista)

Type
Label
  • Hydroxylation of lithocholic acid by selected actinobacteria and filamentous fungi (Articolo in rivista) (literal)
Anno
  • 2013-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.steroids.2012.12.010 (literal)
Alternative label
  • Kollerov, V. V.; Monti, D.; Deshcherevskaya, N. O.; Lobastova, T. G.; Ferrandi, E. E.; Larovere, A.; Gulevskaya, S. A.; Riva, S.; Donova, M. V. (2013)
    Hydroxylation of lithocholic acid by selected actinobacteria and filamentous fungi
    in Steroids
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Kollerov, V. V.; Monti, D.; Deshcherevskaya, N. O.; Lobastova, T. G.; Ferrandi, E. E.; Larovere, A.; Gulevskaya, S. A.; Riva, S.; Donova, M. V. (literal)
Pagina inizio
  • 370 (literal)
Pagina fine
  • 378 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 78 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 9 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 3 (literal)
Note
  • ISI Web of Science (WoS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Russian Academy of Sciences; Consiglio Nazionale delle Ricerche (CNR) (literal)
Titolo
  • Hydroxylation of lithocholic acid by selected actinobacteria and filamentous fungi (literal)
Abstract
  • A strain of Gibberella zeae VKM F-2600 expressed high level of 7 beta-hydroxylating activity towards LCA. Under optimized conditions, the yield of UDCA reached 90% at 1 g/L of LCA and up to 60% at a 8-fold increased substrate loading. The accumulation of the major by-product, 3-keto UDCA, was limited by using selected biotransformation media. (C) 2013 Elsevier Inc. All rights reserved. (literal)
  • Selected actinobacteria and filamentous fungi of different taxonomy were screened for the ability to carry out regio- and stereospecific hydroxylation of lithocholic acid (LCA) at position 7 beta. The production of ursodeoxycholic acid (UDCA) was for the first time shown for the fungal strains of Bipolaris, Gibberella, Cunninghamella and Curvularia, as well as for isolated actinobacterial strains of Pseudonocardia, Saccharothrix, Amycolatopsis, Lentzea, Saccharopolyspora and Nocardia genera. Along with UDCA, chenodeoxycholic (COCA), deoxycholic (DCA), cholic (CA), 7-ketodeoxycholic and 3-ketodeoxycholic acids were detected amongst the metabolites by some strains. (literal)
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