Methylphenidate administration determines enduring changes in neuroglial network in rats (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Methylphenidate administration determines enduring changes in neuroglial network in rats (Articolo in rivista) (literal)

Anno

• 2012-01-01T00:00:00+01:00 (literal)

Alternative label

• Cavaliere, C.; Cirillo G.; Bianco M.R.; Adriani W.; De Simone A.; Leo D.; Perrone-Capano C.; Papa M. (2012)
  Methylphenidate administration determines enduring changes in neuroglial network in rats
  in European neuropsychopharmacology
  (literal)

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• Cavaliere, C.; Cirillo G.; Bianco M.R.; Adriani W.; De Simone A.; Leo D.; Perrone-Capano C.; Papa M. (literal)

Pagina inizio

• 53 (literal)

Pagina fine

• 63 (literal)

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• 22 (literal)

Rivista

• European neuropsychopharmacology (Rivista)

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• PMID: 21550213 (literal)

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• Pubblicazione (literal)

Note

• ISI Web of Science (WOS) (literal)

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• Department of Medicina Pubblica Clinica e Preventiva, Second University of Naples, Naples, Italy b Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Roma, Italy c Department of Pharmacology, University of Montreal, QC, Canada d Department of Biological Sciences, University of Naples \"Federico II\", Naples, Italy e Institute of Genetics and Biophysics \"A. Buzzati Traverso\", CNR, Napoli, Italy (literal)

Titolo

• Methylphenidate administration determines enduring changes in neuroglial network in rats (literal)

Abstract

• Repeated exposure to psychostimulant drugs induces complex molecular and structural modifications in discrete brain regions of the meso-cortico-limbic system. This structural remodeling is thought to underlie neurobehavioral adaptive responses. Administration to adolescent rats of methylphenidate (MPH), commonly used in attention deficit and hyperactivity disorder (ADHD), triggers alterations of reward-based behavior paralleled by persistent and plastic synaptic changes of neuronal and glial markers within key areas of the reward circuits. By immunohistochemistry, we observe a marked increase of glial fibrillary acidic protein (GFAP) and neuronal nitric oxide synthase (nNOS) expression and a down-regulation of glial glutamate transporter GLAST in dorso-lateral and ventro-medial striatum. Using electron microscopy, we find in the prefrontal cortex a significant reduction of the synaptic active zone length, paralleled by an increase of dendritic spines. We demonstrate that in limbic areas the MPH-induced reactive astrocytosis affects the glial glutamatergic uptake system that in turn could determine glutamate receptor sensitization. These processes could be sustained by NO production and synaptic rearrangement and contribute to MPH neuroglial induced rewiring. (C) 2011 Published by Elsevier B.V. (literal)

Prodotto di

• Meccanismi molecolari e cellulari della determinazione neurale, differenziamento neuronale e patologie del sistema nervoso (SV.P16.006.001) (Modulo)
• Institute of genetics and biophysics \"Adriano Buzzati Traverso\" (IGB) (Istituto)

Autore CNR

• CARLA PERRONE CAPANO (Unità di personale esterno)

Incoming links:

Prodotto

• Institute of genetics and biophysics \"Adriano Buzzati Traverso\" (IGB) (Istituto)
• Meccanismi molecolari e cellulari della determinazione neurale, differenziamento neuronale e patologie del sistema nervoso (SV.P16.006.001) (Modulo)

Autore CNR di

• CARLA PERRONE CAPANO (Unità di personale esterno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• European neuropsychopharmacology (Rivista)