http://www.cnr.it/ontology/cnr/individuo/prodotto/ID270945

Superparamagnetic iron oxide nanoparticles stabilized by a poly(amidoamine)-rhenium complex as potential theranostic probe (Articolo in rivista)

Type

Articolo in rivista (Classe)
Prodotto della ricerca (Classe)

Label

Superparamagnetic iron oxide nanoparticles stabilized by a poly(amidoamine)-rhenium complex as potential theranostic probe (Articolo in rivista) (literal)

Anno

2013-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

10.1039/c3dt52377b (literal)

Alternative label

Daniela Maggioni(a,e), Paolo Arosio(b,e), Francesco Orsini(b,e), Anna M. Ferretti(c),Tomas Orlando (d,e), Amedea Manfredi (a), Elisabetta Ranucci (a,e) Paolo Ferruti(a,e),Giuseppe D'Alfonsoa (e) and Alessandro Lascialfari (b,e) (2013)
Superparamagnetic iron oxide nanoparticles stabilized by a poly(amidoamine)-rhenium complex as potential theranostic probe
in Dalton transactions (2003. Online)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Daniela Maggioni(a,e), Paolo Arosio(b,e), Francesco Orsini(b,e), Anna M. Ferretti(c),Tomas Orlando (d,e), Amedea Manfredi (a), Elisabetta Ranucci (a,e) Paolo Ferruti(a,e),Giuseppe D'Alfonsoa (e) and Alessandro Lascialfari (b,e) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

http://pubs.rsc.org/en/content/articlepdf/2014/dt/c3dt52377b (literal)

Rivista

Dalton transactions (Rivista)

Note

ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

(a)Dipartimento di Chimica, Università degli Studi di Milano, Via Golgi 19, 20133 Milano, Italy. E-mail: daniela.maggioni@unimi.it; (b)Dipartimento di Fisica, Università degli Studi di Milano, Via Celoria 16, 20133 Milano, Italy. E-mail: alessandro.lascialfari@unimi.it (c)Laboratorio di Nanotecnologie, CNR-Istituto di Scienze e Tecnologie Molecolari, via G. Fantoli 16/15 I, 20138 Milano, Italy (d)Dipartimento di Fisica, Università degli Studi di Pavia and CNISM, Via Bassi 6, (literal)

Titolo

Superparamagnetic iron oxide nanoparticles stabilized by a poly(amidoamine)-rhenium complex as potential theranostic probe (literal)

Abstract

Three-component nanocomposites, constituted by a superparamagnetic iron oxide core coated with a polymeric surfactant bearing tightly bound Re(CO)3 moieties, were prepared and fully characterized. The water soluble and biocompatible surfactant was a linear poly(amidoamine) copolymer (PAA), containing cysteamine pendants in the minority part (ISA23SH), able to coordinate Re(CO)3 fragments. For the synthesis of the nanocomposites two methods were compared, involving either (i) peptization of bare magnetite nanoparticles by interaction with the preformed ISA23SH-Re(CO)3 complex, or (ii) \"one-pot\" synthesis of iron oxide nanoparticles in the presence of the ISA23SH copolymer, followed by complexation of Re to the SPIO@ISA23SH nanocomposite. Full characterization by TEM, DLS, TGA, SQUID, and relaxometry showed that the second method gave better results. The magnetic cores had a roundish shape, with low dispersion (mean diameter ca. 6 nm) and a tendency to form larger aggregates (detected both by TEM and DLS), arising from multiple interactions of the polymeric coils. Aggregation did not affect the stability of the nano-suspension, found to be stable for many months without precipitate formation. The SPIO@PAA-Re nanoparticles (NPs) showed superparamagnetic behaviour and nuclear relaxivities similar or superior to commercial MRI contrast agents (CAs), which make them promising as MRI \"negative\" CAs. The possibility to encapsulate 186/188Re isotopes (? and ? emitters) gives these novel NPs the potential to behave as bimodal nanostructures devoted to theranostic applications. (literal)

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