http://www.cnr.it/ontology/cnr/individuo/prodotto/ID27067
The biflavonoid Amentoflavone inhibits neovascularization preventing the activity of pro-angiogenic vascular endothelial growth factors (Articolo in rivista)
- Type
- Label
- The biflavonoid Amentoflavone inhibits neovascularization preventing the activity of pro-angiogenic vascular endothelial growth factors (Articolo in rivista) (literal)
- Anno
- 2011-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1074/jbc.M110.186239 (literal)
- Alternative label
Tarallo V, Lepore L, Marcellini M, Dal Piaz F, Tudisco L, Ponticelli S, Wendelboe Lund F, Roepstorff P, Orlandi A, Pisano C, De Tommasi N, and De Falco S. (2011)
The biflavonoid Amentoflavone inhibits neovascularization preventing the activity of pro-angiogenic vascular endothelial growth factors
in The Journal of biological chemistry (Print); American Society Of Biochemistry And Molecular Biology Inc. (ASBMB), Rockville (Stati Uniti d'America)
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Tarallo V, Lepore L, Marcellini M, Dal Piaz F, Tudisco L, Ponticelli S, Wendelboe Lund F, Roepstorff P, Orlandi A, Pisano C, De Tommasi N, and De Falco S. (literal)
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- http://www.jbc.org/content/286/22/19641.long (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
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- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Angiogenesis Lab and Stem Cell Fate Lab, Institute of Genetics and Biophysics, \"Adriano Buzzati-Traverso,\" 80131 Napoli, Italy,
Department of Pharmaceutical Sciences, University of Salerno, 84084 Fisciano (Salerno), Italy,
Research and Development Oncology Area, Sigma-Tau s.p.a., Industrie Farmaceutiche Riunite, 00040 Pomezia (Roma), Italy,
?Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, DK-5230 Odense, Denmark,
Department of Biopathology and Image Diagnostics, Anatomic Pathology Institute, Tor Vergata University, 00133 Roma, Italy (literal)
- Titolo
- The biflavonoid Amentoflavone inhibits neovascularization preventing the activity of pro-angiogenic vascular endothelial growth factors (literal)
- Abstract
- The proangiogenic members of VEGF family and related receptors
play a central role in the modulation of pathological angiogenesis.
Recent insights indicate that, due to the strict biochemical and
functional relationship between VEGFs and related receptors, the
development of a new generation of agents able to target contemporarily
more than one member of VEGFs might amplify the antiangiogenic
response representing an advantage in term of therapeutic
outcome. To identify molecules that are able to prevent the
interaction of VEGFs with related receptors, we have screened
small molecule collections consisting of>100 plant extracts. Here,
we report the isolation and identification from an extract of the
Malian plant Chrozophora senegalensis of the biflavonoid amentoflavone
as an antiangiogenic bioactive molecule. Amentoflavone
can to bindVEGFspreventing the interaction and phosphorylation
of VEGF receptor 1 and 2 (VEGFR-1,VEGFR-2) and to inhibit
endothelial cell migration and capillary-like tube formation
induced by VEGF-A or placental growth factor 1 (PlGF-1) at low
?M concentration. In vivo, amentoflavone is able to inhibit VEGFA-
induced chorioallantoic membrane neovascularization as well
as tumor growth and associated neovascularization, as assessed in
orthotropic melanoma and xenograft colon carcinoma models. In
addition structural studies performed on the amentoflavone?
PlGF-1complexhave provided evidence that this biflavonoid effectively
interacts with the growth factor area crucial for VEGFR-1
receptor recognition. In conclusion, our results demonstrate that
amentoflavone represents an interesting new antiangiogenic molecule
that is able to prevent the activity of proangiogenic VEGF
family members and that the biflavonoid structure is a new chemical
scaffold to develop powerful new antiangiogenic molecules. (literal)
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