A comparative phenotypic and genomic analysis of C57BL/6J and C57BL/6N mouse strains (Articolo in rivista)

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  • A comparative phenotypic and genomic analysis of C57BL/6J and C57BL/6N mouse strains (Articolo in rivista) (literal)
Anno
  • 2013-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1186/gb-2013-14-7-r82 (literal)
Alternative label
  • Simon, Michelle M.; Greenaway, Simon; White, Jacqueline K.; Fuchs, Helmut; Gailus-Durner, Valerie; Wells, Sara; Sorg, Tania; Wong, Kim; Bedu, Elodie; Cartwright, Elizabeth J.; Dacquin, Romain; Djebali, Sophia; Estabel, Jeanne; Graw, Jochen; Ingham, Neil J.; Jackson, Ian J.; Lengeling, Andreas; Mandillo, Silvia; Marvel, Jacqueline; Meziane, Hamid; Preitner, Frederic; Puk, Oliver; Roux, Michel; Adams, David J.; Atkins, Sarah; Ayadi, Abdel; Becker, Lore; Blake, Andrew; Brooker, Debra; Cater, Heather; Champy, Marie-France; Combe, Roy; Danecek, Petr; di Fenza, Armida; Gates, Hilary; Gerdin, Anna-Karin; Golini, Elisabetta; Hancock, John M.; Hans, Wolfgang; Hoelter, Sabine M.; Hough, Tertius; Jurdic, Pierre; Keane, Thomas M.; Morgan, Hugh; Mueller, Werner; Neff, Frauke; Nicholson, George; Pasche, Bastian; Roberson, Laura-Anne; Rozman, Jan; Sanderson, Mark; Santos, Luis; Selloum, Mohammed; Shannon, Carl; Southwell, Anne; Tocchini-Valentini, Glauco P.; Vancollie, Valerie E.; Westerberg, Henrik; Wurst, Wolfgang; Zi, Min; Yalcin, Binnaz; Ramirez-Solis, Ramiro; Steel, Karen P.; Mallon, Ann-Marie; de Angelis, Martin Hrabe; Herault, Yann; Brown, Steve D. M. (2013)
    A comparative phenotypic and genomic analysis of C57BL/6J and C57BL/6N mouse strains
    in GenomeBiology.com (Lond., Print); Biomed Central Ltd., London (Regno Unito)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Simon, Michelle M.; Greenaway, Simon; White, Jacqueline K.; Fuchs, Helmut; Gailus-Durner, Valerie; Wells, Sara; Sorg, Tania; Wong, Kim; Bedu, Elodie; Cartwright, Elizabeth J.; Dacquin, Romain; Djebali, Sophia; Estabel, Jeanne; Graw, Jochen; Ingham, Neil J.; Jackson, Ian J.; Lengeling, Andreas; Mandillo, Silvia; Marvel, Jacqueline; Meziane, Hamid; Preitner, Frederic; Puk, Oliver; Roux, Michel; Adams, David J.; Atkins, Sarah; Ayadi, Abdel; Becker, Lore; Blake, Andrew; Brooker, Debra; Cater, Heather; Champy, Marie-France; Combe, Roy; Danecek, Petr; di Fenza, Armida; Gates, Hilary; Gerdin, Anna-Karin; Golini, Elisabetta; Hancock, John M.; Hans, Wolfgang; Hoelter, Sabine M.; Hough, Tertius; Jurdic, Pierre; Keane, Thomas M.; Morgan, Hugh; Mueller, Werner; Neff, Frauke; Nicholson, George; Pasche, Bastian; Roberson, Laura-Anne; Rozman, Jan; Sanderson, Mark; Santos, Luis; Selloum, Mohammed; Shannon, Carl; Southwell, Anne; Tocchini-Valentini, Glauco P.; Vancollie, Valerie E.; Westerberg, Henrik; Wurst, Wolfgang; Zi, Min; Yalcin, Binnaz; Ramirez-Solis, Ramiro; Steel, Karen P.; Mallon, Ann-Marie; de Angelis, Martin Hrabe; Herault, Yann; Brown, Steve D. M. (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://genomebiology.com/2013/14/7/R82 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 14 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 22 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 7 (literal)
Note
  • ISI Web of Science (WoS) (literal)
  • PubMe (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Med Res Council Harwell; Mary Lyon Ctr; Wellcome Trust Sanger Institute; Helmholtz Association; German Mouse Clin; Helmholtz Association; Helmholtz Association; Centre National de la Recherche Scientifique (CNRS); University of Manchester; University of Manchester; AniRA ImmOs Phenotyping Facil; University of Edinburgh; BBSRC Roslin Institute; Consiglio Nazionale delle Ricerche (CNR); Helmholtz Association; Univ Hosp Bern; University of Lausanne; Technical University of Munich; Max Planck Society; Deutsch Zentrum Neurodegenerat Erkrankungen (literal)
Titolo
  • A comparative phenotypic and genomic analysis of C57BL/6J and C57BL/6N mouse strains (literal)
Abstract
  • Background: The mouse inbred line C57BL/6J is widely used in mouse genetics and its genome has been incorporated into many genetic reference populations. More recently large initiatives such as the International Knockout Mouse Consortium (IKMC) are using the C57BL/6N mouse strain to generate null alleles for all mouse genes. Hence both strains are now widely used in mouse genetics studies. Here we perform a comprehensive genomic and phenotypic analysis of the two strains to identify differences that may influence their underlying genetic mechanisms. Results: We undertake genome sequence comparisons of C57BL/6J and C57BL/6N to identify SNPs, indels and structural variants, with a focus on identifying all coding variants. We annotate 34 SNPs and 2 indels that distinguish C57BL/6J and C57BL/6N coding sequences, as well as 15 structural variants that overlap a gene. In parallel we assess the comparative phenotypes of the two inbred lines utilizing the EMPReSSslim phenotyping pipeline, a broad based assessment encompassing diverse biological systems. We perform additional secondary phenotyping assessments to explore other phenotype domains and to elaborate phenotype differences identified in the primary assessment. We uncover significant phenotypic differences between the two lines, replicated across multiple centers, in a number of physiological, biochemical and behavioral systems. (literal)
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