http://www.cnr.it/ontology/cnr/individuo/prodotto/ID270458
The onset of type 2 diabetes: proposal for a multi-scale model (Articolo in rivista)
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- Label
- The onset of type 2 diabetes: proposal for a multi-scale model (Articolo in rivista) (literal)
- Anno
- 2013-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.2196/resprot.2854 (literal)
- Alternative label
Castiglione, F. and Tieri, P. and De Graaf, A. and Franceschi, C. and Lio, P. and Van Ommen, B. and Mazza, C. and Tuchel, A. and Bernaschi, M. and Samson, C. and Colombo, T. and Castellani, G. C. and Capri, M. and Garagnani, P. and Salvioli, S. and Nguyen, V. A. and Bobeldijk-Pastorova, I. and Krishnan, S. and Cappozzo, A. and Sacchetti, M. and Morettini, M. and Ernst, M. (2013)
The onset of type 2 diabetes: proposal for a multi-scale model
in JMIR Research Protocols
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Castiglione, F. and Tieri, P. and De Graaf, A. and Franceschi, C. and Lio, P. and Van Ommen, B. and Mazza, C. and Tuchel, A. and Bernaschi, M. and Samson, C. and Colombo, T. and Castellani, G. C. and Capri, M. and Garagnani, P. and Salvioli, S. and Nguyen, V. A. and Bobeldijk-Pastorova, I. and Krishnan, S. and Cappozzo, A. and Sacchetti, M. and Morettini, M. and Ernst, M. (literal)
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- 1929-0748 Castiglione, Filippo Tieri, Paolo De Graaf, Albert Franceschi, Claudio Lio, Pietro Van Ommen, Ben Mazza, Claudia Tuchel, Alexander Bernaschi, Massimo Samson, Clare Colombo, Teresa Castellani, Gastone C Capri, Miriam Garagnani, Paolo Salvioli, Stefano Nguyen, Viet Anh Bobeldijk-Pastorova, Ivana Krishnan, Shaji Cappozzo, Aurelio Sacchetti, Massimo Morettini, Micaela Ernst, Marc Journal Article Canada JMIR Res Protoc. 2013 Oct 31;2(2):e44. doi: 10.2196/resprot.2854. (literal)
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- Rivista
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- 1 Consiglio Nazionale delle Ricerche, Istituto per le Applicazioni del Calcolo \"Mauro Picone\", Roma, Italy
2 TNO Toegepast Natuurwetenschappelijk Onderzoek, Microbiology and Systems Biology, Zeist, Netherlands
3 Università di Bologna, Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale, Bologna, Italy
4 University of Cambridge, Computer Laboratory, Faculty of Computer Science and Technology, Cambridge, United Kingdom
5 University of Sheffield, Department of Mechanical Engineering, Sheffield, United Kingdom
6 University of Sheffield, INSIGNEO Institute for in silico Medicine, Sheffield, United Kingdom
7 Medisana Space Technologies GMBH, Dusseldorf, Germany
8 Università di Roma Foro Italico, Dipartimento di Scienze del Movimento Umano e dello Sport, Roma, Italy (literal)
- Titolo
- The onset of type 2 diabetes: proposal for a multi-scale model (literal)
- Abstract
- BACKGROUND: Type 2 diabetes mellitus (T2D) is a common age-related disease, and is a major health concern, particularly in developed countries where the population is aging, including Europe. The multi-scale immune system simulator for the onset of type 2 diabetes (MISSION-T2D) is a European Union-funded project that aims to develop and validate an integrated, multilevel, and patient-specific model, incorporating genetic, metabolic, and nutritional data for the simulation and prediction of metabolic and inflammatory processes in the onset and progression of T2D. The project will ultimately provide a tool for diagnosis and clinical decision making that can estimate the risk of developing T2D and predict its progression in response to possible therapies. Recent data showed that T2D and its complications, specifically in the heart, kidney, retina, and feet, should be considered a systemic disease that is sustained by a pervasive, metabolically-driven state of inflammation. Accordingly, there is an urgent need (1) to understand the complex mechanisms underpinning the onset of this disease, and (2) to identify early patient-specific diagnostic parameters and related inflammatory indicators. OBJECTIVE: We aim to accomplish this mission by setting up a multi-scale model to study the systemic interactions of the biological mechanisms involved in response to a variety of nutritional and metabolic stimuli and stressors. METHODS: Specifically, we will be studying the biological mechanisms of immunological/inflammatory processes, energy intake/expenditure ratio, and cell cycle rate. The overall architecture of the model will exploit an already established immune system simulator as well as several discrete and continuous mathematical methods for modeling of the processes critically involved in the onset and progression of T2D. We aim to validate the predictions of our models using actual biological and clinical data. RESULTS: This study was initiated in March 2013 and is expected to be completed by February 2016. CONCLUSIONS: MISSION-T2D aims to pave the way for translating validated multilevel immune-metabolic models into the clinical setting of T2D. This approach will eventually generate predictive biomarkers for this disease from the integration of clinical data with metabolic, nutritional, immune/inflammatory, genetic, and gut microbiota profiles. Eventually, it should prove possible to translate these into cost-effective and mobile-based diagnostic tools. (literal)
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