http://www.cnr.it/ontology/cnr/individuo/prodotto/ID27004
Meta-analysis of genome-wide association studies for personality (Articolo in rivista)
- Type
- Label
- Meta-analysis of genome-wide association studies for personality (Articolo in rivista) (literal)
- Anno
- 2012-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1038/mp.2010.128 (literal)
- Alternative label
De Moor MH, Costa PT, Terracciano A, Krueger RF, de Geus EJ, Toshiko T, Penninx BW, Esko T, Madden PA, Derringer J, Amin N, Willemsen G, Hottenga JJ, Distel MA, Uda M, Sanna S, Spinhoven P, Hartman CA, Sullivan P, Realo A, Allik J, Heath AC, Pergadia ML, (2012)
Meta-analysis of genome-wide association studies for personality
in Molecular psychiatry
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- De Moor MH, Costa PT, Terracciano A, Krueger RF, de Geus EJ, Toshiko T, Penninx BW, Esko T, Madden PA, Derringer J, Amin N, Willemsen G, Hottenga JJ, Distel MA, Uda M, Sanna S, Spinhoven P, Hartman CA, Sullivan P, Realo A, Allik J, Heath AC, Pergadia ML, (literal)
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- http://www.nature.com/mp/journal/v17/n3/full/mp2010128a.html (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
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- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- 1Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands; 2National Institute on Aging,
NIH, Baltimore, MD, USA; 3Department of Psychology, University of Minnesota, Minneapolis, MN, USA; 4Department of
Psychiatry, University Medical Center Groningen, Groningen, The Netherlands; 5Departments of Clinical Psychology and
Psychiatry, Leiden University, Leiden, The Netherlands; 6Department of Psychiatry, EMGOþ Institute, Neuroscience Campus
Amsterdam, VU University Medical Center Amsterdam, Amsterdam, The Netherlands; 7Institute of Molecular and Cell Biology,
University of Tartu, Tartu, Estonia; 8Estonian Biocentre, Tartu, Estonia; 9Estonian Genome Project of University of Tartu, Tartu,
Estonia; 10Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA; 11Department of
Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands; 12Istituto di Neurogenetica e
Neurofarmacologia, CNR, Monserrato, Cagliari, Italy; 13Department of Genetics, University of North Carolina at Chapel Hill,
Chapel Hill, NC, USA; 14Department of Psychology, University of Tartu, Tartu, Estonia; 15Institute of Genetics and Biophysics,
A Buzzati-Traverso--CNR, Naples, Italy; 16Department of Psychiatry, University of Munich (LMU), Munich, Germany;
17Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland; 18National Institute for Health and
Welfare, Helsinki, Finland; 19Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland;
20Vasa Central Hospital, Vasa, Finland; 21Unit of General Practice, Helsinki University Central Hospital, Helsinki, Finland;
22Folkha¨lsan Research Centre, Helsinki, Finland; 23Wellcome Trust Sanger Institute, Cambridge, UK; 24Broad Institute of
Harvard and MIT, Cambridge, MA, USA; 25Department of Medical Genetics, University of Helsinki and Helsinki University
Hospital, Helsinki, Finland; 26Department of Psychology, Centre for Cognitive Ageing and Cognitive Epidemiology, The
University of Edinburgh, Edinburgh, UK; 27MRC Human Genetics Unit, The Institute of Genetics and Molecular Medicine,
Western General Hospital, Edinburgh, UK; 28Queensland Institute of Medical Research, Brisbane, QLD, Australia;
29Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands; 30Department of
Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA and 31Department of Psychology,
University of Helsinki, University of Helsinki, Helsinki, Finland (literal)
- Titolo
- Meta-analysis of genome-wide association studies for personality (literal)
- Abstract
- Personality can be thought of as a set of characteristics that influence people's thoughts, feelings and behavior across a variety of settings. Variation in personality is predictive of many outcomes in life, including mental health. Here we report on a meta-analysis of genome-wide association (GWA) data for personality in 10 discovery samples (17,375 adults) and five in silico replication samples (3294 adults). All participants were of European ancestry. Personality scores for Neuroticism, Extraversion, Openness to Experience, Agreeableness and Conscientiousness were based on the NEO Five-Factor Inventory. Genotype data of ? 2.4M single-nucleotide polymorphisms (SNPs; directly typed and imputed using HapMap data) were available. In the discovery samples, classical association analyses were performed under an additive model followed by meta-analysis using the weighted inverse variance method. Results showed genome-wide significance for Openness to Experience near the RASA1 gene on 5q14.3 (rs1477268 and rs2032794, P=2.8 × 10(-8) and 3.1 × 10(-8)) and for Conscientiousness in the brain-expressed KATNAL2 gene on 18q21.1 (rs2576037, P=4.9 × 10(-8)). We further conducted a gene-based test that confirmed the association of KATNAL2 to Conscientiousness. In silico replication did not, however, show significant associations of the top SNPs with Openness and Conscientiousness, although the direction of effect of the KATNAL2 SNP on Conscientiousness was consistent in all replication samples. Larger scale GWA studies and alternative approaches are required for confirmation of KATNAL2 as a novel gene affecting Conscientiousness. (literal)
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