http://www.cnr.it/ontology/cnr/individuo/prodotto/ID27003
Expressional and functional analysis of the male-specific cluster mst36F during Drosophila spermatogenesis (Articolo in rivista)
- Type
- Label
- Expressional and functional analysis of the male-specific cluster mst36F during Drosophila spermatogenesis (Articolo in rivista) (literal)
- Anno
- 2010-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1111/j.1365-2583.2010.01033.x (literal)
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- Di Cara F.; Cavaliere D.; Galliero V.; Polito L.C.; Digilio F.A. (literal)
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- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Institute of Genetics and Biophysics A. Buzzati-Traverso, CNR, Naples, Italy;
Cell Biology, Centre for Cardiovascular Science, The University of Edinburgh, Queens Medical Research Institute,
Edinburgh, UK;
Dipartimento Scienze Biologiche, Università degli Studi di Napoli Federico II, Naples, Italy (literal)
- Titolo
- Expressional and functional analysis of the male-specific cluster mst36F during Drosophila spermatogenesis (literal)
- Abstract
- mst36Fa and mst36Fb are two male-specific genes
that are part of a novel gene family recently characterized
in Drosophila melanogaster. The genes are
strictly clustered and show an identical tissue and
temporal expression pattern limited to the male germline.
Here we demonstrate that the transcription of
these two genes, which is triggered by different cis
regulatory elements, responds to the same testisspecific
factors encoded by the aly and can class
meiotic arrest genes. RNA interference was used to
decrease expression of these two genes. We obtained
a reduction of fertility in the transgenic adult males
compared to the wild type. These data suggest that
the Mst36Fa and Mst36Fb proteins may have an
important role in the production of functional sperm. (literal)
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