http://www.cnr.it/ontology/cnr/individuo/prodotto/ID26987
FSHR gene polymorphisms influence bone mineral density and bone turnover in postmenopausal women (Articolo in rivista)
- Type
- Label
- FSHR gene polymorphisms influence bone mineral density and bone turnover in postmenopausal women (Articolo in rivista) (literal)
- Anno
- 2010-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1530/EJE-10-0043 (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Rendina D.; Gianfrancesco F.; De Filippo G.; Merlotti D.; Esposito T.; Mingione A.; Nuti R.; Strazzullo P.; Mossetti G.; Gennari L. (literal)
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- Rivista
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Department of Clinical and Experimental Medicine, Federico II University Medical School, 80131 Naples, Italy, Human Genetic Diseases Laboratory, Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso', Italian National Research Council, via Pietro Castellino, 111, 80131 Naples, Italy,
Unit of Pediatric Endocrinology, Gaetano Rummo Hospital, 82100 Benevento, Italy
and Department of Internal Medicine, Endocrine-Metabolic Sciences and Biochemistry, University of Siena, 83100 Siena, Italy (literal)
- Titolo
- FSHR gene polymorphisms influence bone mineral density and bone turnover in postmenopausal women (literal)
- Abstract
- Objective: FSH, via its receptor (FSHR), influences bone remodeling and osteoclast proliferation and
activity. The aim of this study was to evaluate the influence of two single nucleotide polymorphisms
(SNPs) of the FSHR gene on bone mineral density (BMD) and bone turnover markers (bone alkaline
phosphatase and type I collagen C-telopeptides) in postmenopausal women.
Methods: Two hundred and eighty-nine unrelated postmenopausal women were genotyped for the
SNPs rs1394205 and rs6166. BMD was estimated using dual-energy X-ray absorptiometry and
quantitative ultrasound (QUS) methodologies.
Results: AA rs6166 women showed a lower BMD (femoral neck and total body), lower stiffness index
(calcaneal QUS), and higher serum levels of bone turnover markers compared to GG rs6166 women.
The prevalence of osteoporosis was significantly higher in AA rs6166 women compared with GG
rs6166 women. These results were not influenced by circulating levels of FSH and estrogens.
Conclusion: The SNP rs6166 of the FSHR gene significantly influences BMD in postmenopausal
women. In particular, AA rs6166 women are at increased risk of postmenopausal osteoporosis
compared with GG rs6166 women, independently of circulating levels of FSH and estrogens. Previous
studies have demonstrated that this SNP influences cell and tissue response to hyperstimulation of
FSHR in vivo and in vitro. Our study results appear in agreement with these experimental data and with
known biological actions of FSH/FSHR system in bone homeostasis. (literal)
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