http://www.cnr.it/ontology/cnr/individuo/prodotto/ID26980
Electrospun Polyacrylonitrile Nanofibrous Membranes Tailored for Acetylcholinesterase Immobilization (Articolo in rivista)
- Type
- Label
- Electrospun Polyacrylonitrile Nanofibrous Membranes Tailored for Acetylcholinesterase Immobilization (Articolo in rivista) (literal)
- Anno
- 2010-01-01T00:00:00+01:00 (literal)
- Alternative label
Stoilova O, Manolova N, GABROVSKA K, MARINOV I, GODJEVARGOVA T, MITA DG AND RASHKOV i. (2010)
Electrospun Polyacrylonitrile Nanofibrous Membranes Tailored for Acetylcholinesterase Immobilization
in Journal of bioactive and compatible polymers (Print)
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Stoilova O, Manolova N, GABROVSKA K, MARINOV I, GODJEVARGOVA T, MITA DG AND RASHKOV i. (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Laboratory of Bioactive Polymers, Institute of Polymers, Bulgarian
Academy of Sciences, Acad. G. Bonchev str., 103A, BG-1113 Sofia, Bulgaria
University Prof. Dr. Asen Zlatarov, Department of Biotechnology
Prof Y. Yakimov str., 1, BG-8010 Burgas, Bulgaria
Laboratory of Biophysics, Institute of Genetics and Biophysics CNR
Pietro Castellino str., 111, 80131 Naples, Italy
National Institute of Biosystems and Biostructures (INBB)
Via le Medaglie dOro, 305, 00136 Rome, Italy (literal)
- Titolo
- Electrospun Polyacrylonitrile Nanofibrous Membranes Tailored for Acetylcholinesterase Immobilization (literal)
- Abstract
- Nanofibrous polyacrylonitrile membranes (PANNFM) were obtained by electrospinning and then prepared for immobilizing acetylcholinesterase (AChE). Initially, the chemical modification of PANNFM with ethylenediamine produced reactive groups to overcome their inertness and hydrophobicity. The natural polymer, chitosan, was then tethered on the nanofibrous membranes to improve their biocompatibility. Scanning electron microscopy (SEM) and crosssection SEM were used to determine morphological and porosity changes of the membranes. The immobilized AChE had greater relative activity as well as thermal and storage stability compared to the free enzyme. The bound AChE showed excellent reusability. Chitosan-modified PANNFM was shown to be a suitable strategy for facile immobilization of AChE to produce a promising system that effectively supports biocatalysts. (literal)
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