http://www.cnr.it/ontology/cnr/individuo/prodotto/ID269794

Proteomic analysis of liver tissues subjected to early ischemia/reperfusion injury during human orthotopic liver transplantation. (Articolo in rivista)

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Proteomic analysis of liver tissues subjected to early ischemia/reperfusion injury during human orthotopic liver transplantation. (Articolo in rivista) (literal)

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Vascotto C, Cesaratto L, D'Ambrosio C, Scaloni A, Avellini C, Paron I, Baccarani U, Adani GL, Tiribelli C, Quadrifoglio F, Tell G. (2006)
Proteomic analysis of liver tissues subjected to early ischemia/reperfusion injury during human orthotopic liver transplantation.
in Proteomics (Weinh., Print); Wiley-Blackwell, Oxford (Regno Unito)
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Vascotto C, Cesaratto L, D'Ambrosio C, Scaloni A, Avellini C, Paron I, Baccarani U, Adani GL, Tiribelli C, Quadrifoglio F, Tell G. (literal)

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http://onlinelibrary.wiley.com/doi/10.1002/pmic.200500770/abstract;jsessionid=24FF0C5769A204D767B8D700F6E698EC.f01t01 (literal)

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Department of Biomedical Sciences and Technologies, University of Udine, Udine, Italy Proteomics and Mass Spectrometry Laboratory, ISPAAM, National Research Council, Naples, Italy Institute of Pathology, University of Udine, Udine, Italy Department of Surgery and Transplantation and C.I.M.E., University of Udine, Udine, Italy Centro Studi Fegato, AREA Science Park, Trieste, Italy (literal)

Titolo

Proteomic analysis of liver tissues subjected to early ischemia/reperfusion injury during human orthotopic liver transplantation. (literal)

Abstract

Knowledge of early molecular events occurring upon ischemia/reperfusion (I/R) during liver transplantation (LT) is of great importance to improve the therapeutic intervention of surgical treatment. However, nowadays, few data are available on early protein targets of I/R injury. To identify these proteins, we used a differential proteomics approach in the characterization human liver biopsies during I/R upon LT. Analyses were performed on nine donor livers during LT. By using 2-DE and MALDI-TOF MS, we identified 36 proteins which resulted significantly altered upon I/R injury. The majority of these proteins are functionally involved in lipid and energy metabolism, in different metabolic pathways, in redox signalling and in oxidative-stress response. Our data represent the first global approach in the study of I/R injury in liver. (literal)

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