Recombination proteins mediate meiotic spatial chromosome organization and pairing (Articolo in rivista)

Type
Label
  • Recombination proteins mediate meiotic spatial chromosome organization and pairing (Articolo in rivista) (literal)
Anno
  • 2010-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.cell.2010.02.041 (literal)
Alternative label
  • Storlazzi A.; Gargano S.; Ruprich-Robert G.; Falque M.; David M.; Kleckner N.; Zickler D. (2010)
    Recombination proteins mediate meiotic spatial chromosome organization and pairing
    in Cell (Cambridge)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Storlazzi A.; Gargano S.; Ruprich-Robert G.; Falque M.; David M.; Kleckner N.; Zickler D. (literal)
Pagina inizio
  • 94 (literal)
Pagina fine
  • 106 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 141 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note
  • PMID: 20371348 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 1 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Universite´ Paris-Sud, 91405 Orsay, France Istituto di Genetica e Biofisica A. Buzzati Traverso, CNR, 80131 Naples, Italy UMR de Genetique Vegetale du Moulon, 91190 Gif sur Yvette, France Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02139, USA (literal)
Titolo
  • Recombination proteins mediate meiotic spatial chromosome organization and pairing (literal)
Abstract
  • Meiotic chromosome pairing involves not only recognition of homology but also juxtaposition of entire chromosomes in a topologically regular way. Analysis of filamentous fungus Sordaria macrospora reveals that recombination proteins Mer3, Msh4, and Mlh1 play direct roles in all of these aspects, in advance of their known roles in recombination. Absence of Mer3 helicase results in interwoven chromosomes, thereby revealing the existence of features that specifically ensure \"entanglement avoidance.\" Entanglements that remain at zygotene, i.e., \"interlockings,\" require Mlh1 for resolution, likely to eliminate constraining recombinational connections. Patterns of Mer3 and Msh4 foci along aligned chromosomes show that the double-strand breaks mediating homologous alignment have spatially separated ends, one localized to each partner axis, and that pairing involves interference among developing interhomolog interactions. We propose that Mer3, Msh4, and Mlh1 execute all of these roles during pairing by modulating the state of nascent double-strand break/partner DNA contacts within axis-associated recombination complexes. (literal)
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