http://www.cnr.it/ontology/cnr/individuo/prodotto/ID269570

Kidney transplant monitoring by anti donor specific antibodies (Articolo in rivista)

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Kidney transplant monitoring by anti donor specific antibodies (Articolo in rivista) (literal)

Anno

Alternative label

N Torlone, A Piazza, M Valeri, PI Monaco, L Provenzani, E Poggi, D Adorno, CU Casciani (1992)
Kidney transplant monitoring by anti donor specific antibodies
in Transplant international; Springer-Verlag, Berlin Heidelberg (Germania)
(literal)

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N Torlone, A Piazza, M Valeri, PI Monaco, L Provenzani, E Poggi, D Adorno, CU Casciani (literal)

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Istituto CNR Tipizzazione Tissutale e Problemi della Dialisi Clinical Surgery of \"Tor Vergata\" University (literal)

Titolo

Abstract

Donor-specific anti-HLA antibodies were studied by cytotoxicity crossmatching (CTXM) and flow cytometry crossmatching (FCXM) in 117 kidney transplant candidates; the same study was carried out in 33 cadaver-donor kidney recipients, during the first 3 post-transplant months, for which donor cells were available. Pre-transport evaluation showed that 82.9% of subjects were CTXM negative/FCXM negative, 6.8% of patients were positive in both tests, and 10.3% were CTXM negative/FCCM positive. Post-transplant monitoring for donor-specific antibodies (Abs-DS) showed that nine recipients (27.3%) were FCXM positive; six of them were IgG+ and three IgM+. In comparing these results with the clinical course, a significant association between FCXM IgG+ and rejection episodes was observed (P < 0.01). (literal)

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