http://www.cnr.it/ontology/cnr/individuo/prodotto/ID26952

Modulation of cellular migration and survival by c-Myc through the downregulation of urokinase (uPA) and uPA receptor (Articolo in rivista)

Type

Prodotto della ricerca (Classe)
Articolo in rivista (Classe)

Label

Modulation of cellular migration and survival by c-Myc through the downregulation of urokinase (uPA) and uPA receptor (Articolo in rivista) (literal)

Anno

2010-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

10.1128/MCB.01442-09 (literal)

Alternative label

Alfano D.; Votta G.; Schulze A.; Downward J.; Caputi M.; Stoppelli M.P.; Iaccarino I. (2010)
Modulation of cellular migration and survival by c-Myc through the downregulation of urokinase (uPA) and uPA receptor
in Molecular and cellular biology (Print); ASM, American society for microbiology, Washington, DC (Stati Uniti d'America)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Alfano D.; Votta G.; Schulze A.; Downward J.; Caputi M.; Stoppelli M.P.; Iaccarino I. (literal)

Pagina inizio

1838 (literal)

Pagina fine

1851 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

30 (literal)

Rivista

Molecular and cellular biology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

PMID: 20123981 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

14 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

7 (literal)

Note

ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

Institute of Genetics and Biophysics Adriano Buzzati-Traverso, Consiglio Nazionale delle Ricerche (CNR), Via P. Castellino 111, 80131 Naples, Italy Gene Expression Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3PX, United Kingdom Signal Transduction Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3PX, United Kingdom Department of Cardio-Thoracic Sciences, Second University of Naples, Naples, Italy (literal)

Titolo

Modulation of cellular migration and survival by c-Myc through the downregulation of urokinase (uPA) and uPA receptor (literal)

Abstract

It has been proposed that c-Myc proapoptotic activity accounts for most of its restraint of tumor formation. We established a telomerase-immortalized human epithelial cell line expressing an activatable c-Myc protein. We found that c-Myc activation induces, in addition to increased sensitivity to apoptosis, reductions in cell motility and invasiveness. Transcriptome analysis revealed that urokinase (uPA) and uPA receptor (uPAR) were strongly downregulated by c-Myc. Evidence is provided that the repression of uPA and uPAR may account for most of the antimigratory and proapoptotic activities of c-Myc. c-Myc is known to cooperate with Ras in cellular transformation. We therefore investigated if this cooperation could converge in the control of uPA/uPAR expression. We found that Ras is able to block the effects of c-Myc activation on apoptosis and cellular motility but not on cell invasiveness. Accordingly, the activation of c-Myc in the context of Ras expression had only minor influence on uPAR expression but still had a profound repressive effect on uPA expression. Thus, the differential regulation of uPA and uPAR by c-Myc and Ras correlates with the effects of these two oncoproteins on cell motility, invasiveness, and survival. In conclusion, we have discovered a novel link between c-Myc and uPA/uPAR. We propose that reductions of cell motility and invasiveness could contribute to the inhibition of tumorigenesis by c-Myc and that the regulation of uPA and uPAR expression may be a component of the ability of c-Myc to reduce motility and invasiveness. (literal)

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