Cripto-1 is required for hypoxia to induce cardiac differentiation of mouse embryonic stem cells (Articolo in rivista)

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  • Cripto-1 is required for hypoxia to induce cardiac differentiation of mouse embryonic stem cells (Articolo in rivista) (literal)
Anno
  • 2009-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.2353/ajpath.2009.090218 (literal)
Alternative label
  • Bianco C.; Cotten C.; Lonardo E.; Strizzi L.; Baraty C.; Mancino M.; Gonzales M.; Watanabe K.; Nagaoka T.; Berry C.; Arai A.E.; Minchiotti G.; Salomon D.S. (2009)
    Cripto-1 is required for hypoxia to induce cardiac differentiation of mouse embryonic stem cells
    in The American journal of pathology (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Bianco C.; Cotten C.; Lonardo E.; Strizzi L.; Baraty C.; Mancino M.; Gonzales M.; Watanabe K.; Nagaoka T.; Berry C.; Arai A.E.; Minchiotti G.; Salomon D.S. (literal)
Pagina inizio
  • 2146 (literal)
Pagina fine
  • 2158 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2774077/?tool=pubmed (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 175 (literal)
Rivista
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  • PMID: 19834060 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 5 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • NCI, Mammary Biol & Tumorigenesis Lab, Ctr Canc Res, Bethesda, MD 20892 USA NHLBI, Cardiac Energet Lab, NIH, Bethesda, MD 20892 USA CNR, Inst Genet & Biophys A Buzzati Traverso, Stem Cell Fate Lab, Naples, Italy (literal)
Titolo
  • Cripto-1 is required for hypoxia to induce cardiac differentiation of mouse embryonic stem cells (literal)
Abstract
  • Cripto-1 is a membrane-bound protein that is highly expressed in embryonic stem cells and in human tumors. in the present study, we investigated the effect of low levels of oxygen, which occurs naturally in rapidly growing tissues, on Cripto-1 expression in mouse embryonic stem (mES) cells and in human embryonal carcinoma cells. During hypoxia, Cripto-1 expression levels were significantly elevated in mES cells and in Ntera-2 or NCCIT human embryonal carcinoma cells, as compared with cells growing with normal oxygen levels. The transcription factor hypoxia-inducible factor-1 alpha directly regulated Cripto-1 expression by binding to hypoxia-responsive elements within the promoter of mouse and human Cripto-1 genes in mES and NCCIT cells, respectively. Furthermore, hypoxia modulated differentiation of mES cells by enhancing formation of beating cardiomyocytes as compared with mES cells that were differentiated under normoxia. However, hypoxia failed to induce differentiation of mES cells into cardiomyocytes in the absence of Cripto-1 expression, demonstrating that Cripto-1 is required for hypoxia to fully differentiate mES cells into cardiomyocytes. Finally, cardiac tissue samples derived from patients who had suffered ischemic heart disease showed a dramatic increase in Cripto-1 expression as compared with nonischemic heart tissue samples, suggesting that hypoxia may also regulate Cripto-1 in vivo. (literal)
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