JAK/STAT signaling pathway mediates cytokine-induced iNOS expression in primary astroglial cell cultures. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• JAK/STAT signaling pathway mediates cytokine-induced iNOS expression in primary astroglial cell cultures. (Articolo in rivista) (literal)

Anno

• 2001-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1002/jnr.1169 (literal)

Alternative label

• 1 Dell'Albani P., 2 Santangelo R., 2 Torrisi L., 2 Nicoletti V.G., 3 de Vellis J. and 2 Giuffrida Stella A.M. (2001)
  JAK/STAT signaling pathway mediates cytokine-induced iNOS expression in primary astroglial cell cultures.
  in Journal of neuroscience research
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• 1 Dell'Albani P., 2 Santangelo R., 2 Torrisi L., 2 Nicoletti V.G., 3 de Vellis J. and 2 Giuffrida Stella A.M. (literal)

Pagina inizio

• 417 (literal)

Pagina fine

• 424 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 65 (literal)

Rivista

• Journal of neuroscience research (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 8 (literal)

Note

• Google Scholar (literal)
• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1 Institute of Biomaging and Pathophysiology of Central Nervous System (IBFSNC)-CNR, Piazza Roma, Catania, Italy; 2 Department of Chemical Sciences, Section of Biochemistry and Molecular Biology, Faculty of Medicine, University of Catania, Catania, Italy; 3 Mental Retardation Research Center , Neuropsychiatric Institute, Center for the Health Sciences, Los Angeles, California. (literal)

Titolo

• JAK/STAT signaling pathway mediates cytokine-induced iNOS expression in primary astroglial cell cultures. (literal)

Abstract

• The production of nitric oxide by the calcium-independent inducible nitric oxide synthase (iNOS) in glial cells has been implicated in the neuropathogenesis of various diseases. It is well known that in response to lipopolysaccharide (LPS) and cytokines, such as IFN-gamma, glial cells are induced to synthesize large amount of nitric oxide (NO) (Bolaños et al., 1996; Nicoletti et al., 1998). The signaling transduction pathways for iNOS transcription in astroglial cells have however not yet been established. Because IFN-gamma receptor chains are associated with Janus tyrosine kinases (JAK1 and JAK2) (Darnell et al., 1994), we analyzed the involvement of the JAK/STAT signal transduction pathway in iNOS expression. Our study shows increased JAK2 and STAT1 alpha/beta tyrosine phosphorylation in primary astroglial cell culture after treatment with IFN-gamma and LPS. A temporal correlation was observed between JAK2 and STAT1 alpha/beta tyrosine phosphorylation, the appearance of interferon-regulatory factor-1 (IRF-1) mRNA and the iNOS expression. Inhibition experiments showed that JAK2 and STAT1 alpha/beta tyrosine phosphorylation were necessary for IFN gamma-mediated iNOS induction in astroglial cells. We conclude that JAK2 and STAT1 alpha/beta tyrosine phosphorylation is an early event involved in the expression of iNOS in astroglial cells. (literal)

Prodotto di

• Markers molecolari nelle malattie ereditarie e tumori del Sistema Nervoso (ME.P02.011.001) (Modulo)
• Institute of neurological sciences (ISN) (Istituto)

Autore CNR

• PAOLA DELL'ALBANI (Unità di personale interno)

Insieme di parole chiave

• Parole chiave di "JAK/STAT signaling pathway mediates cytokine-induced iNOS expression in primary astroglial cell cultures." (Insieme di parole chiave)

Incoming links:

Autore CNR di

• PAOLA DELL'ALBANI (Unità di personale interno)

Prodotto

• Institute of neurological sciences (ISN) (Istituto)
• Markers molecolari nelle malattie ereditarie e tumori del Sistema Nervoso (ME.P02.011.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of neuroscience research (Rivista)

Insieme di parole chiave di

• Parole chiave di "JAK/STAT signaling pathway mediates cytokine-induced iNOS expression in primary astroglial cell cultures." (Insieme di parole chiave)