Identification of Tissue Restricted Transcripts in Human Islets (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Identification of Tissue Restricted Transcripts in Human Islets (Articolo in rivista) (literal)

Anno

• 2004-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1210/en.2004-0691 (literal)

Alternative label

• Maffei A.; Liu Z.; Witkowski P.; Moschella F.; Del Pozzo G.; Liu E.; Herold K.; Winchester R.J.; Hardy M.A. and Harris P.E. (2004)
  Identification of Tissue Restricted Transcripts in Human Islets
  in Endocrinology (Philadelphia)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Maffei A.; Liu Z.; Witkowski P.; Moschella F.; Del Pozzo G.; Liu E.; Herold K.; Winchester R.J.; Hardy M.A. and Harris P.E. (literal)

Pagina inizio

• 4513 (literal)

Pagina fine

• 4521 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 145 (literal)

Rivista

• Endocrinology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 10 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Natl Res Ctr, Inst Genet & Biophys Adriano Buzzati Traverso, I-80125 Naples, Italy Med Univ Gdansk, Dept Gen Surg, PL-80210 Gdansk, Poland Columbia Univ, Sch Med, Dept Med, New York, NY 10032 USA Columbia Univ, Sch Med, Dept Pediat, New York, NY 10032 USA Columbia Univ, Sch Med, Dept Surg, New York, NY 10032 USA (literal)

Titolo

• Identification of Tissue Restricted Transcripts in Human Islets (literal)

Abstract

• Type 1 diabetes (T1D) is caused by autoimmune destruction of the insulin-producing beta-cells of the islets of Langerhans. One still open question is where naive islet-reactive T cells encounter antigens and become stimulated. In this report we have re-examined the expression of MHC class II (MHCII) genes in human islets to further explore the possibility that non-professional antigen presenting cells (APCs) within islets contribute to autoimmunity. Since development of T1D has been linked to viral infections, we also studied ex-vivo MHCII expression in response to interferon-alpha (IFN alpha) in islet tissue and in different APCs. The findings are: first, MHCII genes expression in human islets is linked with the expression of the class II transactivator isoform transcribed from the promoter IV, similar to that described in non-professional APCs. Second, there is IFN alpha-mediated lineage-specific regulation of MHCII genes expression, seen as a decrease in the accumulation of MHCII transcripts in pancreatic islets opposite to an increase in dendritic cells and beta-lymphoblastoid cell lines. Third, there is allele-specific regulation of the HLA-DQA1 gene by IFN alpha in islet tissue. These findings may begin to explain the molecular events that create favorable conditions for organ-specific autoimmunity and explain the incomplete penetrance of T1D susceptibility alleles. (literal)

Prodotto di

• Analisi cellulare e molecolare della risposta immunitaria indotta da vaccini sintetici (SV.P15.009.002) (Modulo)
• Istituto di genetica e biofisica \"Adriano Buzzati Traverso\" (IGB) (Istituto)

Autore CNR

• ANTONELLA MAFFEI (Persona)
• GIOVANNA DEL POZZO (Unità di personale interno)

Incoming links:

Prodotto

• Istituto di genetica e biofisica \"Adriano Buzzati Traverso\" (IGB) (Istituto)
• Analisi cellulare e molecolare della risposta immunitaria indotta da vaccini sintetici (SV.P15.009.002) (Modulo)

Autore CNR di

• GIOVANNA DEL POZZO (Unità di personale interno)
• ANTONELLA MAFFEI (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Endocrinology (Rivista)