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Magnetic properties of novel superparamagnetic MRI contrast agents based on colloidal nanocrystals (Articolo in rivista)

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Magnetic properties of novel superparamagnetic MRI contrast agents based on colloidal nanocrystals (Articolo in rivista) (literal)

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Corti, M ; Lascialfari, A; Micotti, E; Castellano, A; Donativi, M; Quarta, A; Cozzoli, PD; Manna, L ; Pellegrino, T; Sangregorio, C (2008)
Magnetic properties of novel superparamagnetic MRI contrast agents based on colloidal nanocrystals
in Journal of magnetism and magnetic materials; ELSEVIER SCIENCE B.V., AMSTERDAM (Paesi Bassi)
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Corti, M ; Lascialfari, A; Micotti, E; Castellano, A; Donativi, M; Quarta, A; Cozzoli, PD; Manna, L ; Pellegrino, T; Sangregorio, C (literal)

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1 ] Univ Pavia, Dipartimento Fis A Volta, Unita CNR INFM, I-27100 Pavia, Italy 2 ] CNISM, I-27100 Pavia, Italy 3 ] Univ Milan, Inst Fisiol Gen & Chim Biol G Esposito, Milan, Italy 4 ] S3 CNR INFM, Modena, Italy 5 ] Univ Lecce, Dipartimento Sci Mat, I-73100 Lecce, Italy 6 ] CNR, INFM, Natl Nanotechnol Lab, I-73100 Lecce, Italy 7 ] Univ Florence, INSTM, I-50019 Sesto Fiorentino, Italy 8 ] Univ Florence, Dipartimento Chim, I-50019 Sesto Fiorentino, Italy (literal)

Titolo

Magnetic properties of novel superparamagnetic MRI contrast agents based on colloidal nanocrystals (literal)

Abstract

Novel systems based on colloidal magnetic nanocrystals (NCs), potentially useful as superparamagnetic (SP) contrast agents for magnetic resonance imaging (MRI) have been investigated. The NCs we have studied comprise organic-capped single-crystalline maghemite (gamma-Fe(2)O(3)) cores possessing controlled sizes and shapes. We have comparatively examined spherical and tetrapod-like NCs, the latter being branched particles possessing four arms which depart out at tetrahedral angles from a central point. The as-synthesized NCs are passivated by hydrophobic surfactant molecules and thus are fully dispersible in nonpolar media only. The NCs have been made soluble in aqueous solution by applying a procedure based on the surface intercalation and coating with an amphiphilic polymer shell. NMR relaxivities R(1) and R(2) were compared with ENDOREM(R), one of the standard commercial SP-MRI contrast agent. We found that the spherical NCs exhibit R(1) and R(2) relaxivities slightly lower than those of ENDOREM(R), over the whole frequency range; on the contrary, tetrapods show relaxivities about one order of magnitude lower. The physical origin of such difference in relaxivities between tetrapod-and spheres-based nanostructures is under investigation and it is possibly related to different sources of the magnetic anisotropy. (C) 2008 Elsevier B.V. All rights reserved. (literal)

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