Thermodynamic pathways to genome spatial organization in the cell nucleus (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Thermodynamic pathways to genome spatial organization in the cell nucleus (Articolo in rivista) (literal)

Anno

• 2009-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.bpj.2008.12.3919 (literal)

Alternative label

• Nicodemi M.; Prisco A. (2009)
  Thermodynamic pathways to genome spatial organization in the cell nucleus
  in Biophysical journal (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Nicodemi M.; Prisco A. (literal)

Pagina inizio

• 2168 (literal)

Pagina fine

• 2177 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 96 (literal)

Rivista

• Biophysical journal (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

• PMID: 19289043 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 6 (literal)

Note

• Scopu (literal)
• ISI Web of Science (WOS) (literal)
• Google S (literal)
• PubMe (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Department of Physics and Complexity Science, University of Warwick, Coventry, United Kingdom INFN Naples, Naples, Italy CNR Institute of Genetics and Biophysics ''Buzzati Traverso'', Naples, Italy (literal)

Titolo

• Thermodynamic pathways to genome spatial organization in the cell nucleus (literal)

Abstract

• The architecture of the eukaryotic genome is characterized by a high degree of spatial organization. Chromo- somes occupy preferred territories correlated to their state of activity and, yet, displace their genes to interact with remote sites in complex patterns requiring the orchestration of a huge number of DNA loci and molecular regulators. Far from random, this organization serves crucial functional purposes, but its governing principles remain elusive. By computer simulations of a statistical mechanics model, we show how architectural patterns spontaneously arise from the physical interaction between soluble binding molecules and chromosomes via collective thermodynamics mechanisms. Chromosomes colocalize, loops and territories form, and find their relative positions as stable thermodynamic states. These are selected by thermodynamic switches, which are regulated by concentrations/affinity of soluble mediators and by number/location of their attachment sites along chromosomes. Our thermodynamic switch model of nuclear architecture, thus, explains on quantitative grounds how well-known cell strategies of upregulation of DNA binding proteins or modification of chromatin structure can dynamically shape the organization of the nucleus. (literal)

Prodotto di

• Istituto di genetica e biofisica \"Adriano Buzzati Traverso\" (IGB) (Istituto)
• Analisi cellulare e molecolare della risposta immunitaria indotta da vaccini sintetici (SV.P15.009.002) (Modulo)

Autore CNR

• MARIO NICODEMI (Persona)
• ANTONELLA PRISCO (Persona)

Incoming links:

Prodotto

• Istituto di genetica e biofisica \"Adriano Buzzati Traverso\" (IGB) (Istituto)
• Analisi cellulare e molecolare della risposta immunitaria indotta da vaccini sintetici (SV.P15.009.002) (Modulo)

Autore CNR di

• MARIO NICODEMI (Persona)
• ANTONELLA PRISCO (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Biophysical journal (Rivista)