Synaptonemal complex assembly in C. elegans is dispensable for loading strand-exchange (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Synaptonemal complex assembly in C. elegans is dispensable for loading strand-exchange (Articolo in rivista) (literal)

Anno

• 2003-01-01T00:00:00+01:00 (literal)

Alternative label

• Colaiácovo MP; MacQueen AJ; Martinez-Perez E; McDonald K; Adamo A; La Volpe A; Villeneuve AM (2003)
  Synaptonemal complex assembly in C. elegans is dispensable for loading strand-exchange
  in Developmental cell
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Colaiácovo MP; MacQueen AJ; Martinez-Perez E; McDonald K; Adamo A; La Volpe A; Villeneuve AM (literal)

Pagina inizio

• 463 (literal)

Pagina fine

• 474 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 5 (literal)

Rivista

• Developmental cell (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Stanford University School of Medicine Stanford, California Electron Microscope Laboratory University of California, Berkeley California Istituto di Genetica e Biofisica \"Adriano Buzzati- Traverso\"-CNR Italy (literal)

Titolo

• Synaptonemal complex assembly in C. elegans is dispensable for loading strand-exchange (literal)

Abstract

• Here we probe the relationships between assembly of the synaptonemal complex (SC) and progression of recombination between homologous chromosomes during Caenorhabditis elegans meiosis. We identify SYP-2 as a structural component of the SC central region and show that central region assembly depends on proper morphogenesis of chromosome axes. We find that the SC central region is dispensable for initiation of recombination and for loading of DNA strand-exchange protein RAD-51, despite the fact that extensive RAD-51 loading normally occurs in the context of assembled SC. Further, persistence of RAD-51 foci and absence of crossover products in meiotic mutants suggests that SC central region components and recombination proteins MSH-4 and MSH-5 are required to promote conversion of resected double-strand breaks into stable post-strand exchange intermediates. Our data also suggest that early prophase barriers to utilization of sister chromatids as repair templates do not depend on central region assembly. (literal)

Prodotto di

• Istituto di genetica e biofisica \"Adriano Buzzati Traverso\" (IGB) (Istituto)
• Sviluppo e funzionamento dei sistemi complessi - Uso di modelli biologici (SV.P16.005.001) (Modulo)

Autore CNR

• ADELE ADAMO (Persona)
• ADRIANA LA VOLPE (Persona)

Incoming links:

Prodotto

• Istituto di genetica e biofisica \"Adriano Buzzati Traverso\" (IGB) (Istituto)
• Sviluppo e funzionamento dei sistemi complessi - Uso di modelli biologici (SV.P16.005.001) (Modulo)

Autore CNR di

• ADELE ADAMO (Persona)
• ADRIANA LA VOLPE (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Developmental cell (Rivista)