Competitive ELISA-based screening of plant derivatives for the inhibition of VEGF family members interaction with vascular endothelial growth factor receptor 1 (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Competitive ELISA-based screening of plant derivatives for the inhibition of VEGF family members interaction with vascular endothelial growth factor receptor 1 (Articolo in rivista) (literal)

Anno

• 2008-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1055/s-2008-1034346 (literal)

Alternative label

• Ponticelli S, Braca A, De Tommasi N, De Falco S (2008)
  Competitive ELISA-based screening of plant derivatives for the inhibition of VEGF family members interaction with vascular endothelial growth factor receptor 1
  in Planta medica; Georg Thieme Verlag KG, Stuttgart (Germania)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Ponticelli S, Braca A, De Tommasi N, De Falco S (literal)

Pagina inizio

• 401 (literal)

Pagina fine

• 406 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• https://www.thieme-connect.com/DOI/DOI?10.1055/s-2008-1034346 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 74 (literal)

Rivista

• Planta medica (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 4 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1 Angiogenesis Lab and Stem Cell Fate Lab, Istituto di Genetica e Biofisica `Adriano Buzzati-Traverso', CNR, Napoli, Italy 2 Dipartimento di Chimica Bioorganica e Biofarmacia, Università di Pisa, Pisa, Italy 3 Dipartimento di Scienze Farmaceutiche, Università di Salerno, Fisciano (SA), Italy (literal)

Titolo

• Competitive ELISA-based screening of plant derivatives for the inhibition of VEGF family members interaction with vascular endothelial growth factor receptor 1 (literal)

Abstract

• The activation of vascular endothelial growth factor receptor-1 (VEGFR-1, also known as Flt-1) is crucial in many physiological and pathological conditions, like angiogenesis, cancer, inflammation, hematopoiesis, bone marrow precursors/stem cells recruitment in tumor angiogenesis, and metastasis formation. Many recent reportsindicate that molecules able to antagonize Flt-1 activity have gained a strong interest in the view of therapeutic approaches. In order to identify new compounds able to interfere in the Flt-1 recognition by VEGFs family members, we have developed a highly sensitive competitive ELISA-based screening to study plant extracts and derivatives. Several fractions of the n-butanol extract of Pteleopsis suberosa leaves and of the chloroform extract of Parinari campestris leaves demonstrated by a bioassay-guided fractionation an evident inhibition of VEGF-A or placental growth factor (PlGF) interaction with Flt-1, with an inhibition over 50% in particular for the VEGF-A/Flt-1 interaction at a concentration of 100¼g/mL. This activity seems be due to thepresence of a combination of compounds actingsynergistically. (literal)

Editore

• Georg Thieme Verlag KG (Editore)

Prodotto di

• Istituto di genetica e biofisica \"Adriano Buzzati Traverso\" (IGB) (Istituto)
• Identificazione di regolatori del differenziamento, della motilità e dell'apoptosi delle cellule staminali (SV.P15.008.001) (Modulo)

Autore CNR

• SANDRO DE FALCO (Unità di personale interno)
• SALVATORE PONTICELLI (Persona)

Incoming links:

Prodotto

• Istituto di genetica e biofisica \"Adriano Buzzati Traverso\" (IGB) (Istituto)
• Identificazione di regolatori del differenziamento, della motilità e dell'apoptosi delle cellule staminali (SV.P15.008.001) (Modulo)

Autore CNR di

• SANDRO DE FALCO (Unità di personale interno)
• SALVATORE PONTICELLI (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Planta medica (Rivista)

Editore di

• Georg Thieme Verlag KG (Editore)