Chronic cerebrospinal venous insufficiency in multiple sclerosis: A highly prevalent age-dependent phenomenon (Articolo in rivista)

Type
Label
  • Chronic cerebrospinal venous insufficiency in multiple sclerosis: A highly prevalent age-dependent phenomenon (Articolo in rivista) (literal)
Anno
  • 2013-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1186/1471-2377-13-20 (literal)
Alternative label
  • Lanzillo, R. and Mancini, M. and Liuzzi, R. and Di Donato, O. and Salvatore, E. and Maglio, V. and Vacca, G. and Amato, L. and D'Anna, G. and Brunetti, A. and Brescia Morra, V. (2013)
    Chronic cerebrospinal venous insufficiency in multiple sclerosis: A highly prevalent age-dependent phenomenon
    in BMC neurology (Online)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Lanzillo, R. and Mancini, M. and Liuzzi, R. and Di Donato, O. and Salvatore, E. and Maglio, V. and Vacca, G. and Amato, L. and D'Anna, G. and Brunetti, A. and Brescia Morra, V. (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni
  • cited By (since 1996)3 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://www.scopus.com/inward/record.url?eid=2-s2.0-84874016810&partnerID=40&md5=68836f4ed41ea01ee741549fdfd5d888 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 13 (literal)
Rivista
Note
  • Scopu (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Department of Neurological Sciences, Federico II University School of Medicine, Naples, Italy b Institute of Biostructure and Bioimaging, National Research Council of Italy (CNR), Naples, Italy c IRCCS, SDN Foundation, Institute of Diagnostic and Nuclear development, Naples, Italy (literal)
Titolo
  • Chronic cerebrospinal venous insufficiency in multiple sclerosis: A highly prevalent age-dependent phenomenon (literal)
Abstract
  • Background: This study aimed to investigate the prevalence and clinical relevance of chronic cerebrospinal venous insufficiency (CCSVI) in multiple sclerosis (MS) patients and healthy controls using extra- and intracranial colour Doppler sonography.Methods: We examined 146 MS patients, presenting with a clinically isolated syndrome, relapsing-remitting, secondary progressive, or primary progressive MS, and 38 healthy controls. Sonographic examination was performed according to Zamboni's protocol and was performed by three independent sonographers. The results of sonographic examination were compared with clinical and demographic characteristics of the patients. Results: CCSVI, defined as the presence of at least two positive Zamboni's criteria, was found in 76% of MS patients and 16% of control subjects. B-mode anomalies of internal jugular veins, such as stenosis, malformed valves, annuli, and septa were the most common lesions detected in MS patients (80.8%) and controls (47.4%). We observed a positive correlation between sonographic diagnosis of CCSVI and the patients' age (p = 0.003). However, such a correlation was not found in controls (p = 0.635). Notably, no significant correlations were found between sonographic signs of CCSVI and clinical characteristics of MS, except for absent flow in the jugular veins, which was found more often in primary (p<0.005) and secondary (p<0.05) progressive patients compared with non-progressive patients. Absent flow in jugular veins was significantly correlated with patients' age (p < 0.0001). Conclusions: Sonographically defined CCSVI is common in MS patients. However, CCSVI appears to be primarily associated with the patient's age, and poorly correlated with the clinical course of the disease (literal)
Prodotto di
Autore CNR
Insieme di parole chiave

Incoming links:


Autore CNR di
Prodotto
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi
Insieme di parole chiave di
data.CNR.it