Chemistry and Biology of the Potent Endotoxin from a Burkholderia dolosa Clinical Isolate from a Cystic Fibrosis Patient (Articolo in rivista)

Type
Label
  • Chemistry and Biology of the Potent Endotoxin from a Burkholderia dolosa Clinical Isolate from a Cystic Fibrosis Patient (Articolo in rivista) (literal)
Anno
  • 2013-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1002/cbic.201300062 (literal)
Alternative label
  • Flaviana Di Lorenzo, Luisa Sturiale, Angelo Palmigiano, Luigi Lembo Fazio, Ida Paciello, Carla P Coutinho, Isabel Sá-Correia, MariaLina Bernardini, Rosa Lanzetta, Domenico Garozzo, Alba Silipo, Antonio Molinaro (2013)
    Chemistry and Biology of the Potent Endotoxin from a Burkholderia dolosa Clinical Isolate from a Cystic Fibrosis Patient
    in ChemBioChem (Print); Wiley-VCH - Weinheim, Wheinheim (Germania)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Flaviana Di Lorenzo, Luisa Sturiale, Angelo Palmigiano, Luigi Lembo Fazio, Ida Paciello, Carla P Coutinho, Isabel Sá-Correia, MariaLina Bernardini, Rosa Lanzetta, Domenico Garozzo, Alba Silipo, Antonio Molinaro (literal)
Pagina inizio
  • 1105 (literal)
Pagina fine
  • 1115 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://onlinelibrary.wiley.com/doi/10.1002/cbic.201300062/full (literal)
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  • 14 (literal)
Rivista
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  • 11 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 9 (literal)
Note
  • Google Scholar (literal)
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  • Dipartimento di Scienze Chimiche, Università di Napoli Federico II, Complesso Universitario Monte S. Angelo, Via Cintia 4, 80126 Napoli (Italy) Istituto di Chimica e Tecnologia dei Polimeri-ICTP-CNR, Via P. Gaifami 18, 95126 Catania (Italy) Dipartimento di Biologia e Biotecnologie \"C. Darwin\", Sapienza-Università di Roma, Piazzale Aldo Moro, 5-00185 Roma (Italy) IBB--Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Department of Bioengineering, Instituto Superior Técnico, Technical University of Lisbon, Av. Rovisco Pais, 1049-001 Lisbon (Portugal) Istituto Pasteur-Fondazione Cenci Bolognetti, Sapienza-Università di Roma, Piazzale Aldo Moro 5, 00185 Roma (Italy), 00185 Roma (Italy) (literal)
Titolo
  • Chemistry and Biology of the Potent Endotoxin from a Burkholderia dolosa Clinical Isolate from a Cystic Fibrosis Patient (literal)
Abstract
  • This is the first report of the chemical and biological properties of the lipooligosaccharide (LOS) endotoxin isolated from Burkholderia dolosa IST4208, an isolate recovered from a cystic fibrosis (CF) patient in a Portuguese CF center. B. dolosa is a member of the Burkholderia cepacia complex, a group of closely related species that are highly problematic and opportunistic pathogens in CF. B. dolosa infection leads to accelerated loss of lung function and decreased survival. The structural determination of its endotoxin was achieved using a combination of chemistry and spectroscopy, and has revealed a novel endotoxin structure. The purified LOS was tested for its immunostimulatory activity on human HEK 293 cells expressing TLR-4, MD-2, and CD-14. In these assays, the LOS showed strong proinflammatory activity. (literal)
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