http://www.cnr.it/ontology/cnr/individuo/prodotto/ID267242

A cyclic model for bimodal activation of calcium activated potassium channels in radish vacuoles (Articolo in rivista)

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A cyclic model for bimodal activation of calcium activated potassium channels in radish vacuoles (Articolo in rivista) (literal)

Anno

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Carpaneto A (2001)
A cyclic model for bimodal activation of calcium activated potassium channels in radish vacuoles
in Rivista di biologia (testo stamp.); Tilgher-Genova, Genova (Italia)
(literal)

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Istituto di Cibernetica e Biofisica C.N.R., Via De Marini 6, 16149 Genova, Italy (literal)

Titolo

A cyclic model for bimodal activation of calcium activated potassium channels in radish vacuoles (literal)

Abstract

This paper presents the mathematical framework of a cyclic model proposed for describing the transition between a fast and a slow mode (fast-slow effect) induced by the application of step membrane potentials to ion channels from radish vacuoles. A voltage stimulation pulse with frequency in the range of 2 Hz or higher increased the activation time (slow made) of the recorded currents. When the frequency of the stimulation pattern wets restored to 0.1 Hz the activation time decreased twofold (fast mode). This experimental result cannot be explained by classical kinetic theory. The model, based on a simple extension of the Hodgkin and Huxley chain, describes the whole current experimental data and provides hints on the structural conformation of ion channels (literal)

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