BRC-1 acts in the inter-sister pathway of meiotic double-strand break repair (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• BRC-1 acts in the inter-sister pathway of meiotic double-strand break repair (Articolo in rivista) (literal)

Anno

• 2008-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1038/sj.embor.7401167 (literal)

Alternative label

• Adamo A; Montemauri P; Silva N; Ward JD; Boulton SJ; La Volpe A (2008)
  BRC-1 acts in the inter-sister pathway of meiotic double-strand break repair
  in EMBO reports (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Adamo A; Montemauri P; Silva N; Ward JD; Boulton SJ; La Volpe A (literal)

Pagina inizio

• 287 (literal)

Pagina fine

• 292 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 9 (literal)

Rivista

• EMBO reports (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 3 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso' CNR, Napoli, Italy Department of Structural and Functional Biology, University of Naples 'Federico II'Complesso di MonteS.Angelo,Napoli, Italy ClareHallLaboratories, LondonResearch Institute, Cancer Research UK, South Mimms, Hertfordshire, UK (literal)

Titolo

• BRC-1 acts in the inter-sister pathway of meiotic double-strand break repair (literal)

Abstract

• The breast and ovarian cancer susceptibility protein BRCA1 is evolutionarily conserved and functions in DNA double-strand break (DSB) repair through homologous recombination, but its role in meiosis is poorly understood. By using genetic analysis, we investigated the role of the Caenorhabditis elegans BRCA1 orthologue (brc-1) during meiotic prophase. The null mutant in the brc-1 gene is viable, fertile and shows the wild-type complement of six bivalents in most diakinetic nuclei, which is indicative of successful crossover recombination. However,brc-1 mutants show an abnormal increase in apoptosis and RAD-51 foci at pachytene that are abolished by loss of spo-11 function, suggesting a defect in meiosis rather than during premeiotic DNA replication. In genetic backgrounds in which chiasma formation is abrogated, such as him-14/MSH4 and syp-2, loss of brc-1 leads to chromosome fragmentation suggesting that brc-1 is dispensable for crossing over but essential for DSB repair through inter-sister recombination. (literal)

Prodotto di

• Istituto di genetica e biofisica \"Adriano Buzzati Traverso\" (IGB) (Istituto)
• Sviluppo e funzionamento dei sistemi complessi - Uso di modelli biologici (SV.P16.005.001) (Modulo)

Autore CNR

• ADRIANA LA VOLPE (Persona)
• ADELE ADAMO (Persona)

Incoming links:

Prodotto

• Istituto di genetica e biofisica \"Adriano Buzzati Traverso\" (IGB) (Istituto)
• Sviluppo e funzionamento dei sistemi complessi - Uso di modelli biologici (SV.P16.005.001) (Modulo)

Autore CNR di

• ADELE ADAMO (Persona)
• ADRIANA LA VOLPE (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• EMBO reports (Rivista)