Modular usage of the HLA-DRA promoter in extra-hematopoietic and hematopoietic cell types of transgenic mice (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Modular usage of the HLA-DRA promoter in extra-hematopoietic and hematopoietic cell types of transgenic mice (Articolo in rivista) (literal)

Anno

• 2005-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1111/j.1742-4658.2005.04740.x (literal)

Alternative label

• Ezio Giorda; Leonardo Sibilio; Aline Martayan; Giordana Feriotto; Nicoletta Bianchi; Carlo Mischiati; Francesca Di Rosa; Laura Pozzi; Roberto Gambari; Patrizio Giacomini (2005)
  Modular usage of the HLA-DRA promoter in extra-hematopoietic and hematopoietic cell types of transgenic mice
  in The FEBS journal (Online)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Ezio Giorda; Leonardo Sibilio; Aline Martayan; Giordana Feriotto; Nicoletta Bianchi; Carlo Mischiati; Francesca Di Rosa; Laura Pozzi; Roberto Gambari; Patrizio Giacomini (literal)

Pagina inizio

• 3214 (literal)

Pagina fine

• 3226 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 272 (literal)

Rivista

• ?The ?FEBS journal (Rivista)

Note

• ISI Web of Science (WOS) (literal)
• PubMe (literal)
• Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Giorda E; Sibilio L; Martayan A; Giacomini P= Laboratory of Immunology, Regina Elena Cancer Institute CRS, Rome, Italy Feriotto G; Bianchi N; Gambari R = ER-Gentech, Biotechnology Center, University of Ferrara, Italy Mischiati C= Department of Biochemistry and Molecular Biology, Molecular Biology Section, University of Ferrara, Italy Pozzi L= Telethon Transgenic Mouse Facilities, Regina Elena Cancer Institute CRS, Rome, Italy Gambari R= Interdisciplinary Center for the Study of Inflammation, University of Ferrara, Italy (literal)

Titolo

• Modular usage of the HLA-DRA promoter in extra-hematopoietic and hematopoietic cell types of transgenic mice (literal)

Abstract

• Class II MHC genes (for example, the human HLA-DRA gene) are expressed at the cell surface in many professional and nonprofessional antigen-presenting cells in a variety of anatomical locations. Here, we report about 13 mouse transgenic lines (11 of which have not been previously described) generated with four distinct sets of DRA transgenes carrying progressive, informative 5' and 3' deletions. DRA expression was assessed in B lymphocytes, dendritic cells, macrophages, and extra-hematopoietic cells (particularly kidney epithelial cells). A compact transcriptional unit was identified that efficiently directs DRA expression [both constitutive and interferon (IFN)-gamma induced] in extra-hematopoietic tissues and dendritic cells. It extends from position -266 upstream of the transcription initiation site to position +119 downstream of the last DRA exon. The same fragment, however, did not efficiently direct IFN-gamma-induced DRA expression in macrophages, that required additional 5' sequences. Thus, IFN-gamma uses distinct promoter segments and mechanisms to up-regulate class II in different cell lineages. In contrast to previous results in transgenic mice expressing murine class II transgenes, we were unable to generate reproducible patterns of HLA-DRA expression in B cells. (literal)

Prodotto di

• Institute of genetics and biophysics \"Adriano Buzzati Traverso\" (IGB) (Istituto)
• Analisi cellulare e molecolare della risposta immunitaria indotta da vaccini sintetici (SV.P15.009.002) (Modulo)

Autore CNR

• FRANCESCA DI ROSA (Persona)

Incoming links:

Autore CNR di

• FRANCESCA DI ROSA (Persona)

Prodotto

• Institute of genetics and biophysics \"Adriano Buzzati Traverso\" (IGB) (Istituto)
• Analisi cellulare e molecolare della risposta immunitaria indotta da vaccini sintetici (SV.P15.009.002) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• ?The ?FEBS journal (Rivista)