Orthopedia homeodomain protein is essential for diencephalic dopaminergic neuron development (Articolo in rivista)

Type
Label
  • Orthopedia homeodomain protein is essential for diencephalic dopaminergic neuron development (Articolo in rivista) (literal)
Anno
  • 2007-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.cub.2007.04.003 (literal)
Alternative label
  • Ryu S.; Mahler J.; Acampora D.; Holzschuh J.; Erhardt S.; Omodei D.; Simeone A. and Driever W. (2007)
    Orthopedia homeodomain protein is essential for diencephalic dopaminergic neuron development
    in Current biology
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Ryu S.; Mahler J.; Acampora D.; Holzschuh J.; Erhardt S.; Omodei D.; Simeone A. and Driever W. (literal)
Pagina inizio
  • 873 (literal)
Pagina fine
  • 880 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 17 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 10 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#descrizioneSinteticaDelProdotto
  • Pubblicazione (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Department of Developmental Biology Institute Biology 1 University of Freiburg Hauptstrasse 1 D-79104 Freiburg Germany Centro di Ingegneria Genetica Biotecnologie Avanzate and European School of Molecular Medicine Via Comunale Margherita 482 80145 Naples Italy Institute of Genetics and Biophysics A. Buzzati-Traverso Consiglio Nazionale delle Ricerche Via P. Castellino 111 80131 Naples Italy (literal)
Titolo
  • Orthopedia homeodomain protein is essential for diencephalic dopaminergic neuron development (literal)
Abstract
  • Neurons that produce dopamine as a neurotransmitter constitute a heterogeneous group involved in the control of various behaviors and physiology. In mammals, dopaminergic neurons are found in distinct clusters mainly located in the ventral midbrain and the caudal forebrain [1]. Although much is known about midbrain dopaminergic neurons, development of diencephalic dopaminergic neurons is poorly understood. Here we demonstrate that Orthopedia (Otp) homeodomain protein is essential for the development of specific subsets of diencephalic dopaminergic neurons. Zebrafish embryos lacking Otp activity are devoid of dopaminergic neurons in the hypothalamus and the posterior tuberculum. Similarly, Otp-/- mouse [2, 3] embryos lack diencephalic dopaminergic neurons of the A11 group, which constitutes the diencephalospinal dopaminergic system. In both systems, Otp is expressed in the affected dopaminergic neurons as well as in potential precursor populations, and it might contribute to dopaminergic cell specification and differentiation. In fish, overexpression of Otp can induce ectopic tyrosine hydroxylase and dopamine transporter expression, indicating that Otp can specify aspects of dopaminergic identity. Thus, Otp is one of the few known transcription factors that can determine aspects of the dopaminergic phenotype and the first known factor to control the development of the diencephalospinal dopaminergic system. (literal)
Prodotto di
Autore CNR

Incoming links:


Prodotto
Autore CNR di
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi
data.CNR.it